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Plozasiran for Severe Hypertriglyceridemia and Risk of Pancreatitis.

At month 12, median triglyceride fell 79% and 81% with plozasiran; placebo-adjusted difference -45 and -47 percentage points. Acute pancreatitis rates were 1 versus 5 per 100 patient-years (rate ratio 0.22; P=0.008).

Why it mattersAn siRNA lowering triglycerides in severe hypertriglyceridemia could cut acute pancreatitis admissions; check whether the pancreatitis reduction was significant before changing referral practice.

Pregnancy Outcomes in Women With Endometriosis: A Systematic Review and Meta-Analysis of Maternal and Neonatal Complications

Endometriosis may influence pregnancy beyond its established association with infertility by affecting placentation, gestational duration, maternal health, and neonatal outcomes. This systematic review and meta-analysis aimed to determine whether endometriosis is associated with adverse maternal, fetal, and neonatal complications. PubMed/Medical Literature Analysis and Retrieval System Online…

Why it mattersIf endometriosis independently raises risks like preterm birth and placental complications, these pregnancies warrant closer antenatal surveillance rather than routine care.

Palbociclib (CDK4/6 Inhibitor)-Related Uveitis With Cystoid Macular Edema in Metastatic Breast Cancer: A Case Report and Review of Small-Molecule Targeted Drug-Related Uveitis

Palbociclib is one of the cyclin-dependent kinase 4/6 (CDK4/6) inhibitors that are used together with hormone therapy for relapsed and metastatic breast cancer as standard therapy. In this report, we describe the case of a patient who presented with bilateral anterior uveitis with cystoid macular edema in the right eye while on palbociclib with fulvestrant. The patient underwent partial breast…

Why it mattersPalbociclib is now standard in metastatic breast cancer; bilateral uveitis with macular edema is a sight-threatening toxicity to recognise early and refer, not dismiss as conjunctivitis.

Progression of Coronary Artery Abnormalities Following Timely Intravenous Immunoglobulin Administration in Children With Incomplete Kawasaki Disease: A Retrospective Cohort Study

Among 360 without baseline abnormalities, 24 (6.7%) developed new coronary abnormalities. Abnormalities rose from 36 (9.1%) to 51 (12.9%) overall; mean maximum z-score rose 1.09 to 1.32 (difference 0.23; 95% CI 0.08-0.38)

Why it mattersEven with timely IVIG, children with incomplete Kawasaki disease can develop and progress coronary abnormalities, so baseline and follow-up echocardiography remains essential in these patients.

Comparative Functional and Radiological Outcomes of Locking Plate Fixation Versus Proximal Humeral Nailing for Displaced Two- and Three-Part Proximal Humerus Fractures: A 12-Month Comparative Study

Proximal humerus fractures are common injuries, and both locking plate fixation and intramedullary nailing are established surgical treatment options. However, the relative advantages of these techniques remain debated, particularly regarding perioperative efficiency, functional recovery, range of motion, fracture union, and implant-related complications. Methods: This prospective,…

Why it mattersHead-to-head 12-month data on plate versus nail for displaced proximal humerus fractures helps you choose the implant by union, range of motion and complication profile rather than habit.

Proposed Seven-Checkpoint Pathway for Implementing Low-Dose Aspirin for Preeclampsia Prevention in Primary Care

Low-dose aspirin (LDA) is recommended for preeclampsia prevention in pregnancies at increased risk, yet its effectiveness in routine care depends on more than prescribing. Patients must undergo appropriate assessment and counseling, receive a prescription when indicated, and then obtain the medication, initiate treatment, and maintain the prescribed regimen until its planned discontinuation.…

Why it mattersPrescribing aspirin is the easy step; this pathway targets the drop-offs — risk assessment, counselling, actually buying and continuing the drug — that decide whether at-risk mothers are protected.

Adrenal Crisis Associated With Graves' Disease Relapse After Levothyroxine Reintroduction in Established Autoimmune Polyglandular Syndrome Type 2: A Case Report and Review of Thyroid-Adrenal Interactions

Two months after being euthyroid with negative thyroid-stimulating immunoglobulins, subclinical hypothyroidism led to levothyroxine 50 µg/day; one month later she had adrenal crisis with hyponatremia, mild hyperkalemia, elevated ACTH and overt thyrotoxicosis with TSI.

Why it mattersIn APS-2 with adrenal insufficiency, restoring levothyroxine can precipitate crisis as thyroid hormone accelerates cortisol clearance—check adrenal status before treating the thyroid.

Timing and Predictors of Renal Involvement in Childhood Immunoglobulin A (IgA) Vasculitis: A Systematic Review of De-intensification of Renal Surveillance

Renal involvement is the principal determinant of long-term prognosis in childhood immunoglobulin A vasculitis, but the optimal duration and intensity of surveillance remain uncertain. This systematic review examined the timing and predictors of renal involvement, focusing on residual risk after normal assessments and the evidence informing surveillance de-intensification. MEDLINE through PubMed,…

Why it mattersBefore you shorten urine monitoring in a child with IgA vasculitis, this review maps when nephritis actually appears and which patients still warrant prolonged surveillance.