Archive

Plozasiran for Severe Hypertriglyceridemia and Risk of Pancreatitis.

At month 12, median triglyceride fell 79% and 81% with plozasiran; placebo-adjusted difference -45 and -47 percentage points. Acute pancreatitis rates were 1 versus 5 per 100 patient-years (rate ratio 0.22; P=0.008).

Endocrinology · NEJM · 9h

Rates of Diabetes Diagnoses and Diabetic Ketoacidosis Episodes Before Versus During the COVID-19 Pandemic

If pandemic-era children presented with more severe DKA at diabetes onset, lower your threshold for glucose testing in sick kids and counsel families on earlier symptom recognition.

Paediatrics · Cureus · 10h

Evaluating Online Patient Information and AI-Generated Advice for Testicular Microlithiasis: Readability and Information Quality

Incidental microlithiasis already causes disproportionate anxiety; the online and chatbot material your patients read is written above an 11-year reading age, so expect misunderstanding and counsel directly.

Urology · Cureus · 16h

Hospitalizations for Postpartum Hemorrhage and Maternal Mortality: A Time-Series Study in Espírito Santo, Brazil, From 2010 to 2024

Tracks whether PPH admission rates and deaths are falling over 15 years — a benchmark for how well your own unit's hemorrhage protocols are holding up.

Obstetrics & Gynaecology · Cureus · 17h

Comparative Functional and Radiological Outcomes of Locking Plate Fixation Versus Proximal Humeral Nailing for Displaced Two- and Three-Part Proximal Humerus Fractures: A 12-Month Comparative Study

Head-to-head 12-month data on plate versus nail for displaced proximal humerus fractures helps you choose the implant by union, range of motion and complication profile rather than habit.

Orthopaedics · Cureus · 18h

Proposed Seven-Checkpoint Pathway for Implementing Low-Dose Aspirin for Preeclampsia Prevention in Primary Care

Prescribing aspirin is the easy step; this pathway targets the drop-offs — risk assessment, counselling, actually buying and continuing the drug — that decide whether at-risk mothers are protected.

Obstetrics & Gynaecology · Cureus · 18h

Establishing the Baseline: A Practical Approach to Admitting Adults With Intellectual Disability

No numerical results. The authors propose recording eight baseline domains at admission with someone who knows the patient, and treating any change from that baseline as possible acute illness.

General Medicine · Cureus · 20h

SC reserves verdict on plea concerning procedure of declaring patient brain dead

The court's ruling will set the certification process you must follow before withdrawing organ support — get the paperwork wrong and donation or withdrawal stalls.

Neurology · ETHealthworld · 21h

Adrenal Crisis Associated With Graves' Disease Relapse After Levothyroxine Reintroduction in Established Autoimmune Polyglandular Syndrome Type 2: A Case Report and Review of Thyroid-Adrenal Interactions

Two months after being euthyroid with negative thyroid-stimulating immunoglobulins, subclinical hypothyroidism led to levothyroxine 50 µg/day; one month later she had adrenal crisis with hyponatremia, mild hyperkalemia, elevated ACTH and overt thyrotoxicosis with TSI.

Endocrinology · Cureus · 21h

Acute Intermittent Porphyria Presenting as the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) and Refractory Hyperemesis in Pregnancy: A Diagnostic Challenge

In refractory hyperemesis with persistent hyponatraemia, consider porphyria before labelling it pregnancy sickness; urine porphobilinogen during an attack confirms it and avoids years of misdiagnosis.

Obstetrics & Gynaecology · Cureus · 22h

Pregnancy Outcomes in Women With Endometriosis: A Systematic Review and Meta-Analysis of Maternal and Neonatal Complications

If endometriosis independently raises risks like preterm birth and placental complications, these pregnancies warrant closer antenatal surveillance rather than routine care.

Obstetrics & Gynaecology · Cureus · 22h

Wearables, AI and women's heart health

Wearable-derived data only helps if it changes management; expect more atrial fibrillation and risk signals in women, but demand a workflow for acting on them.

Cardiology · Fierce Healthcare · 22h

Palbociclib (CDK4/6 Inhibitor)-Related Uveitis With Cystoid Macular Edema in Metastatic Breast Cancer: A Case Report and Review of Small-Molecule Targeted Drug-Related Uveitis

Palbociclib is now standard in metastatic breast cancer; bilateral uveitis with macular edema is a sight-threatening toxicity to recognise early and refer, not dismiss as conjunctivitis.

Oncology · Cureus · 23h

Rhabdomyolysis After a Low-Energy Fall With an Intertrochanteric Fracture: A Case Report

In elderly hip fracture patients, check urine colour and CK even after a trivial fall — rhabdomyolysis can develop within hours and threaten renal function.

Orthopaedics · Cureus · 23h

Timing and Predictors of Renal Involvement in Childhood Immunoglobulin A (IgA) Vasculitis: A Systematic Review of De-intensification of Renal Surveillance

Before you shorten urine monitoring in a child with IgA vasculitis, this review maps when nephritis actually appears and which patients still warrant prolonged surveillance.

Paediatrics · Cureus · 1d

Comparative Efficacy, Safety, and Healthcare Resource Utilization of Levosalbutamol Versus Racemic Salbutamol in Asthma and Wheezing: A Systematic Review of Physiological, Clinical, and Management Outcomes

Levosalbutamol gives comparable bronchodilation with fewer tachycardia and tremor effects, so consider it when beta-agonist side effects limit dosing in asthma and wheezing.

General Medicine · Cureus · 1d

Prevalence of Anemia in Hospitalized Internal Medicine Patients: A Cross-Sectional Study

Anemia is common in your admitted medical patients; this gives prevalence and complication data to justify routine CBC review and transfusion thresholds on the ward.

General Medicine · Cureus · 1d

Early High-Protein Enteral Nutrition in Mechanically Ventilated Intensive Care Unit Patients: A Propensity-Matched Retrospective Cohort Study

Retrospective, propensity-matched evidence on whether pushing ≥1.5 g/kg/day protein within 48 hours changes outcomes in your ventilated patients — hypothesis-generating, not practice-changing.

Anaesthesiology · Cureus · 1d

Improving Physician Orders for Life-Sustaining Treatment (POLST) Documentation Through an Age-Friendly Health Systems 4Ms What Matters Workflow in an Outpatient Geriatric Clinic

Embedding a POLST prompt in routine geriatric visits raised documented end-of-life preferences — a workflow you can copy into your own outpatient practice.

General Medicine · Cureus · 1d

Moyamoya Disease Masquerading as a Transient Ischemic Attack: The Importance of Early Vascular Imaging

In young adults with recurrent transient focal deficits, consider moyamoya and image the intracranial vessels early rather than labelling it TIA and stopping at antiplatelets.

Neurology · Cureus · 1d

Early Postoperative Neurological Changes After Surgical Treatment of Traumatic Spinal Injury: A Retrospective Cohort Study

AIS grade shifts early after traumatic spinal injury surgery are heterogeneous, so document baseline status and assessment timing before attributing change to the operation.

Orthopaedics · Cureus · 1d

Clinical Outcomes of Medication-Related Osteonecrosis of the Jaw After Switching From Antiresorptive Agents to Teriparatide

If your patient on bisphosphonates or denosumab develops exposed jaw bone, switching to teriparatide may be a treatment option worth discussing with their oral surgeon.

General Medicine · Cureus · 1d

Centre proposes expansion of import gateways for drugs and medical devices

More entry ports for drugs and devices could shorten stock-outs of imported medicines and equipment your patients depend on, though cold-chain handling at new points needs watching.

Medicine · ETHealthworld · 1d

Adverse Events, Complications, and Secondary Surgical Intervention for Animal-Derived Resorbable Oral Barrier Membranes: A Report-Based Analysis of the Food and Drug Administration Manufacturer and User Facility Device Experience (FDA MAUDE) Database

If you place animal-derived resorbable membranes in guided bone regeneration, MAUDE reports link infection and dehiscence to reoperation — counsel patients and watch these sites closely.

General Surgery · Cureus · 1d

Temporal Trend of Acute Flaccid Paralysis Notifications in Brazil: An Ecological Time-Series Study, 2016–2025

AFP notification rates measure polio surveillance sensitivity; this shows whether Brazil's system would catch a reintroduction, the same metric your district uses for polio-free certification.

Paediatrics · Cureus · 1d

A Clinically Significant Interaction Between Cannabis, Clonazepam, and Methadone: A Case Report

Recurrent episodes of sedation with hypoactivity, confusion and apnea, self-resolving in two to three hours. No further episodes after stopping methadone and clonazepam and switching to lorazepam, despite continued cannabis use

Psychiatry · Cureus · 1d

TAPP5: Technical Modification of Transabdominal Preperitoneal (TAPP) Inguinal Hernia Repair Using Three 5-mm Ports

All-5-mm ports may reduce port-site morbidity and scar size in TAPP hernia repair, but mesh delivery through a 5-mm incision needs validation before routine adoption.

General Surgery · Cureus · 2d

Follicular Mucinosis of the Eyebrow as a Cutaneous Clue to Classic Hodgkin Lymphoma: A Case Report

Skin biopsy showed follicular mucinosis (Alcian blue positive); lymph node biopsy confirmed classic Hodgkin lymphoma, nodular sclerosis. ABVD chemotherapy produced complete metabolic response on PET/CT with hair regrowth

Oncology · Cureus · 2d

Access, Engagement, and Depression and Anxiety Outcomes in an Employer-Sponsored Virtual Behavioral Health Program: A Retrospective Cohort Study

Employer-linked virtual behavioral health integrated with primary care improved depression and anxiety outcomes, supporting referral to such programs where access to in-person psychiatry is limited.

Psychiatry · Cureus · 2d

Association Between Oral Hygiene and Bronchoscopic Microbiological Findings in Patients Undergoing Bronchoscopy for Non-infectious Indications

Higher oral hygiene score trended toward lower odds of oral flora (aOR 0.853 per point, 95% CI 0.707-1.028, p = 0.094). Yield differed by modality: BAL 86%, biopsy 43%, brushings 15%; BAL-brush concordance poor (κ = 0.042)

General Medicine · Cureus · 2d

Unplanned Return to Theatre Following Hip Hemiarthroplasty: Indications and Clinical Implications

Knowing which complications drive unplanned reoperation after hemiarthroplasty lets you counsel families on prognosis and target perioperative care where it counts.

Orthopaedics · Cureus · 2d

Management of Degenerative Knee Disease With Bone Marrow Aspirate Concentrate and Intermittent Platelet-Based Therapy: Nearly Nine Years of Follow-Up

A single case report cannot justify offering BMAC or platelet injections to knee osteoarthritis patients; long-term benefit remains unproven without controlled data.

Orthopaedics · Cureus · 2d

Prenatal-Onset Seizures, Multimodal Treatment Response, and Precision Therapy Considerations in KCNT1 p.Arg474His Epilepsy of Infancy With Migrating Focal Seizures: A Case Report

Seizures were refractory to levetiracetam and phenobarbital and worsened paradoxically with sodium channel-acting antiseizure medications. After a multimodal regimen including cannabidiol and a ketogenic diet, a transient seizure-free interval occurred.

Paediatrics · Cureus · 2d

Contralateral Salvage: Strategic Cross-Hand Replantation Following Bilateral Mutilating Injuries

When one limb is unsalvageable but the opposite hand is intact, cross-hand replantation can restore a dominant hand rather than leaving the patient with two prostheses.

Orthopaedics · Cureus · 2d

Radiographic Bone Fill in Molar Furcations Following Nonsurgical Treatment of Stage III, Grade C Periodontitis: A Four-Year Follow-Up Case Report

Mean PPD fell from 4.8 mm at baseline to 2.0 mm at two years and 2.1 mm at three years; plaque 86% to 6% and BOP 82% to 7%. Radiographs at about 31 months suggested bone fill near molar furcations

Medicine · Cureus · 2d

Penile Epithelioid Sarcoma in an 18-Year-Old Male: A Diagnosis of Severe Implication

A young man's urinary retention proved to be an aggressive sarcoma — consider tissue diagnosis in unexplained obstructive voiding rather than assuming benign stricture.

Urology · Cureus · 2d

STAT+: FDA, CMS look to collaborate with states on health AI

US regulators moving toward state-level AI oversight and clinician liability shields signals the direction Indian AI device and CDSCO policy will likely follow.

Medicine · STAT News — Health Tech · 2d

Progression of Coronary Artery Abnormalities Following Timely Intravenous Immunoglobulin Administration in Children With Incomplete Kawasaki Disease: A Retrospective Cohort Study

Among 360 without baseline abnormalities, 24 (6.7%) developed new coronary abnormalities. Abnormalities rose from 36 (9.1%) to 51 (12.9%) overall; mean maximum z-score rose 1.09 to 1.32 (difference 0.23; 95% CI 0.08-0.38)

Paediatrics · Cureus · 2d

Immediate Molar Implant Placement With Planned Immediate Restorative Management: A Retrospective Descriptive Case Series

Pre-existing infection was present in 37 of 45 sites with documented status (82.2%). Only three complications were recorded; one mandibular site lacked primary stability and had abutment placement delayed.

Orthopaedics · Cureus · 2d

Long-Term Cardiovascular Safety of Melatonin: Why Dose, Duration, and Patient Phenotype Matter

Before prescribing long-term melatonin, weigh that cardiovascular safety data are lacking and risk likely varies by dose, formulation and patient phenotype.

Cardiology · Cureus · 2d