Archive

SC reserves verdict on plea concerning procedure of declaring patient brain dead

The court's ruling will set the certification process you must follow before withdrawing organ support — get the paperwork wrong and donation or withdrawal stalls.

Neurology · ETHealthworld · 22h

Moyamoya Disease Masquerading as a Transient Ischemic Attack: The Importance of Early Vascular Imaging

In young adults with recurrent transient focal deficits, consider moyamoya and image the intracranial vessels early rather than labelling it TIA and stopping at antiplatelets.

Neurology · Cureus · 1d

Seizure Control, Tolerability, and Direct Drug Cost of Lamotrigine Versus Carbamazepine in Adults With Focal Epilepsy in a Randomized Open-Label Trial in Bangladesh

For self-paying patients, lamotrigine's tolerability must be weighed against its higher cost when choosing first-line monotherapy for focal epilepsy.

Neurology · Cureus · 2d

A Case of Delayed-Onset, Apomorphine-Induced Haemolytic Anaemia

If a Parkinson's patient on apomorphine infusion develops anaemia years later, consider drug-induced haemolysis and send a direct Coombs' test rather than assuming progression.

Neurology · Cureus · 2d

Ischemic Stroke as the Initial Presentation of an Underlying Neuroinfectious Disease

In young or recurrent stroke with atypical imaging, consider neuroinfectious vasculitis — it mimics routine cerebrovascular disease and changes workup and treatment.

Neurology · Cureus · 3d

Management of Neuropathic Pain in Patients With Spinal Cord Injuries: A Narrative Review

No trial results or effect sizes are presented. The authors conclude that multimodal pharmaceutical, non-pharmaceutical and interventional strategies appear most effective, but response varies between patients and relief remains difficult.

Neurology · Cureus · 3d

Efficacy and Safety of Levetiracetam Versus Fosphenytoin in Adult Convulsive Status Epilepticus: An Open-Label Randomized Controlled Trial

Gives you local randomised evidence for choosing between two second-line IV agents when diazepam fails, rather than relying on habit or imported guidelines.

Neurology · Cureus · 4d

ABNORMAL Score for the Etiologic Triage of Parkinsonism: Development and Apparent Diagnostic Performance

A bedside score bundling onset age, tempo and dopaminergic response could help you separate PD from atypical parkinsonism earlier, though it still needs external validation.

Neurology · Cureus · 6d

Juvenile Dentatorubral-Pallidoluysian Atrophy (DRPLA) in a Patient From Northeastern Mexico: Whole-Genome Sequencing With ExpansionHunter as a Key Diagnostic Tool

WGS with ExpansionHunter flagged a pathogenic-range ATN1 repeat; orthogonal testing confirmed alleles of 13 and 64 CAG repeats, supporting the molecular diagnosis of DRPLA.

Neurology · Cureus · 6d

Prion Diseases in Focus: A Review of Diagnosis and Treatment

No curative therapy exists. Protein amplification assays (PMCA, RT-QuIC, tASA) show promising sensitivity and specificity; blood prion protein detection may allow minimally invasive testing. Experimental anti-PrP antibodies and misfolding inhibitors remain unproven.

Neurology · Cureus · 7d

Multiple Causes of Death Associated With Stroke in Young Adults Aged 20-49 Years in Brazil: A Population-Based Time-Series Analysis From 2015 to 2024

Young adults dying of stroke often carry coexisting conditions that single-cause coding hides; reviewing the full chain may change how you work up a 30-year-old.

Neurology · Cureus · 7d

Slit-Like Ventricles in Diffuse Cerebral Edema After Cardiac Arrest: A Case Report

Slit-like ventricles on post-arrest CT can reflect diffuse edema rather than normal anatomy, so read them alongside parenchymal loss before prognosticating to families.

Neurology · Cureus · 7d

Parvovirus B19-Associated Meningoencephalitis in an Adult: A Rare Cause of Central Nervous System Infection

Consider B19V in adults with headache, photophobia and diplopia plus non-specific CSF; a positive CSF PCR is hard to interpret, so pair it with serology before committing.

Neurology · Cureus · 8d

Scalp Swelling Caused by Extracranial Extension of Meningioma

A scalp lump with new neurological symptoms warrants imaging — this case shows meningioma can erode calvarium and present extracranially, so don't dismiss it as benign.

Neurology · Cureus · 8d

Spinal Teratoma in an Adult Female Patient: A Case Report

Rare intramedullary teratomas mimic common radiculopathy; keep them on the differential when a young adult has progressive bilateral leg symptoms and nonspecific back pain.

Neurology · Cureus · 8d

Generalized Myasthenia Gravis Identified During Evaluation for Streptococcal Pharyngitis: A Case Report

Fatigable weakness or ptosis in a patient seen for a sore throat can be myasthenia gravis; consider it before attributing bulbar symptoms to infection.

Neurology · Cureus · 8d

The Microbiota-Gut-Brain Axis in Neurological and Neuropsychiatric Disorders: A Literature Review

Frames gut microbiota as a modifiable pathway in schizophrenia and autism, but this is a review of associations, not evidence that targeting it changes outcomes.

Neurology · Cureus · 9d

Persistent and compartmentalized T cell immunity in ALS.

Identifies long-lived intrathecal T cell clones in ALS, suggesting CNS-targeted immunomodulation as a therapeutic avenue rather than peripheral immunosuppression.

Neurology · Nature Medicine · 9d

Clarithromycin-Associated Carbamazepine Toxicity Presenting as a Posterior Circulation Stroke Mimic

Serum carbamazepine was 18.6 mg/L and sodium 122 mmol/L, down from a baseline of approximately 130 mmol/L. Symptoms resolved within 48 hours of withholding carbamazepine and correcting hypovolaemia.

Neurology · Cureus · 11d

Stratified Outpatient Management and Radiological Follow-Up After Endovascular Treatment for Unruptured Intracranial Aneurysms

A risk-stratified follow-up schedule after unruptured aneurysm coiling could cut routine imaging visits for stable patients while keeping closer watch on higher-risk anatomy.

Neurology · Cureus · 11d

Age- and Sex-Specific Distribution of Vascular and Behavioural Risk Factors Among Patients With Acute Ischaemic Stroke: A Hospital-Based Study From North India

Dyslipidaemia 56.2%, hypertension 55.4%, diabetes 55.1%. Hypertension and dyslipidaemia rose with age (both p<0.001). RHD was more common in females (15.0% vs 6.1%, p=0.010); combined CAD/RHD 50.3% vs 38.9% (p=0.044).

Neurology · Cureus · 12d

Cerebral Infarction As the Presenting Feature of Janus Kinase 2 (JAK2) V617F-Positive Polycythemia Vera: A Case Report

In young stroke patients without usual risk factors, check a haemoglobin and JAK2 — undiagnosed polycythemia vera is a treatable cause of arterial infarction.

Neurology · Cureus · 13d

Mechanical Thrombectomy 24 to 72 Hours after Large-Vessel Ischemic Stroke.

If late-window thrombectomy still improves outcomes in selected patients with salvageable tissue, your 24-hour treatment cutoff for transfer and imaging decisions needs revisiting.

Neurology · NEJM · 13d

Remibrutinib versus teriflunomide in relapsing multiple sclerosis (REMODEL-1 and REMODEL-2): two randomised, phase 3 trials.

An oral, CNS-penetrant BTK inhibitor with an active comparator against teriflunomide could give your relapsing MS patients a new oral option if the event-driven results hold.

Neurology · Lancet · 13d

Trial of Endovascular Therapy for Mild Stroke with Large-Vessel Occlusion.

Excellent 90-day outcome (mRS 0-1) in 69.4% with endovascular therapy versus 50.0% with medical management alone (odds ratio 2.32; 95% CI 1.41 to 3.81; P<0.001). Symptomatic intracranial haemorrhage occurred in 3 patients per group.

Neurology · NEJM · 13d

Saved by Bell's Palsy: Recurrent Facial Weakness in a Patient With a Cerebellopontine Angle Mass

Recurrent facial palsy with headache or vertigo warrants imaging — a cerebellopontine angle mass can mimic Bell's, and steroids alone would delay its diagnosis.

Neurology · Cureus · 14d

Association of the 2HELPS2B Score With Impaired Recovery of Consciousness and In-Hospital Mortality in Critically Ill Patients: A Multicenter Retrospective Study

A routine EEG risk score may flag sedated ICU patients unlikely to regain consciousness, helping you time neuroprognostication and family discussions earlier.

Neurology · Cureus · 14d

Prognostic Value of High-Sensitivity C-reactive Protein, Interleukin-6, and Lipoprotein(a) in Acute Ischemic Stroke and Recurrent Cerebrovascular Events: A Systematic Review and Meta-Analysis

Elevated biomarkers were associated with poor functional outcome (pooled OR 2.28, 95% CI 1.77-2.80), with substantial heterogeneity (I² = 90.38%). hs-CRP was most consistent (OR 2.29, 95% CI 1.96-2.61); IL-6 did not reach significance (OR 2.30, 95% CI 0.21-4.40).

Neurology · Cureus · 14d

FDA Launches New Program to Advance Neuroscience Medical Product Development

A faster FDA pathway for neuro drugs could shorten the wait before your patients with Parkinson's, epilepsy or Alzheimer's get new options.

Neurology · FDA — Press Announcements · 14d

Assessment of Compliance With the National Institute for Health and Care Excellence Guidance in the Management of Patients Referred Following a First Suspected Seizure: A Retrospective Clinical Audit

Specialist assessment within two weeks in 5 of 53 (9.4%). ECG, recurrence-risk assessment and safety/driving advice documented in 100%. Of 17 needing EEG, 1 (5.9%) had it within 72 hours; mean time to EEG about 12.5 weeks.

Neurology · Cureus · 22 Oct

Bulbar-Predominant Myasthenia Gravis Associated With Muscle-Specific Tyrosine Kinase Antibodies: A Diagnostic Challenge

MuSK antibodies were markedly elevated at 1934 U/mL, confirming MuSK-positive myasthenia gravis with predominant bulbar involvement after AChR antibodies were negative.

Neurology · Cureus · 21 Oct

Vitamin B6 Doses on United States Dietary Supplement Labels Relative to the Tolerable Upper Intake Level: A Census of the National Institutes of Health Dietary Supplement Label Database

Ask patients on high-dose B6 about tingling or numbness — supplement labels often exceed the 100 mg/day UL that causes peripheral neuropathy.

Neurology · Cureus · 20 Oct

Vestibular Epilepsy Presenting With Isolated Recurrent Vertigo and Postictal Headache: A Case Report

Before labelling brief recurrent vertigo as vestibular migraine or BPPV, consider vestibular epilepsy — postictal headache and one-to-two-minute attacks are the clues, and no diagnostic criteria exist yet.

Neurology · Cureus · 20 Oct

Effect of Vestibular Stimulation Exercises on the Level of Consciousness in Patients With Intracerebral Hemorrhage: A Systematic Review

Graded vestibular exercises may be a cheap bedside adjunct to multisensory stimulation for ICH survivors with low consciousness, but this review's evidence is early and needs confirmation before routine use.

Neurology · Cureus · 20 Oct

Fingolimod-Associated Primary Cutaneous Cryptococcosis: A Case Report and Scoping Review With a Focus on Immune Monitoring

On fingolimod, lymphopenia can seed skin cryptococcosis; check absolute lymphocyte counts and biopsy atypical skin lesions rather than assuming benign dermatosis.

Neurology · Cureus · 18 Oct

First Reported Coexistence of Acetylcholine Receptor-Positive Myasthenia Gravis and Genetically Confirmed Spinocerebellar Ataxia Type 6

New weakness or fatigability in a patient with known ataxia may be treatable myasthenia gravis, not progression — consider AChR antibody testing before attributing it to the underlying disease.

Neurology · Cureus · 18 Oct

Early-onset Alzheimer's disease looks very different to late-onset version: Study

In younger patients with depression, dizziness or head injury, keep early-onset Alzheimer's on the differential — the comorbidity pattern differs from late-onset disease.

Neurology · ETHealthworld · 13 Oct

Human-artificial intelligence collaboration for comanaging epilepsy in real time.

Seizure detectors improved precision from patient feedback alone, without expert intervention, in a pseudoprospective simulation; the platform processed sleep, medication, cognition and seizure probability biomarkers.

Neurology · Nature Medicine · 13 Oct

Nicotinamide Riboside for Patients With Early-Stage Parkinson Disease: The NOPARK Randomized Clinical Trial.

If this NAD-precursor trial is negative, you can stop fielding patient questions about nicotinamide riboside supplements for early Parkinson disease.

Neurology · JAMA · 8 Oct

Migraine.

Understanding migraine as a multi-system neurovascular disorder supports earlier recognition and use of targeted acute and preventive therapies in your patients.

Neurology · Lancet · 7 Oct