Archive

Wearables, AI and women's heart health

Wearable-derived data only helps if it changes management; expect more atrial fibrillation and risk signals in women, but demand a workflow for acting on them.

Cardiology · Fierce Healthcare · 23h

Long-Term Cardiovascular Safety of Melatonin: Why Dose, Duration, and Patient Phenotype Matter

Before prescribing long-term melatonin, weigh that cardiovascular safety data are lacking and risk likely varies by dose, formulation and patient phenotype.

Cardiology · Cureus · 2d

Average Resting Heart Rate in Indian Patients with Heart Failure with Reduced Ejection Fraction: Results from the Real-World Milestone Registry

Registry data on real-world resting heart rate and HR-lowering prescriptions in Indian HFrEF outpatients show where titration gaps sit against guideline targets.

Cardiology · Cureus · 2d

Pretreatment CHA₂DS₂-VASc-HS Score for Predicting Failed Thrombolysis in ST-Elevation Myocardial Infarction: A Cross-Sectional Diagnostic Accuracy Study in Bangladesh

A pre-thrombolysis score could flag likely fibrinolysis failure before the 90-minute mark, letting you plan rescue PCI earlier where cath lab access is limited.

Cardiology · Cureus · 2d

Long-term outcomes after percutaneous coronary intervention with drug-eluting stents versus coronary artery bypass grafting for left main coronary artery disease: a prospective analysis of the multicentre IRIS-MAIN registry.

Real-world Asian registry data on left main revascularisation help you counsel patients on whether stenting or surgery offers better long-term survival.

Cardiology · Lancet · 2d

Hematopoietic loss of KDM6A impairs cardiac recovery in heart failure via epigenetic reprogramming of myeloid cells.

KDM6A deficiency increased myeloid recruitment to the injured heart and reprogrammed monocytes, macrophages and neutrophils toward inflammatory, migratory and glycolytic states; IL-1β blockade after MI rescued the adverse cardiac phenotype.

Cardiology · Nature cardiovascular research · 2d

Residual Inflammatory Risk in Patients With Established Atherosclerotic Cardiovascular Disease and Low-Density Lipoprotein Cholesterol at Target: A Systematic Review and Meta-Analysis

Even at LDL-C target, an hs-CRP ≥2 mg/L flags patients with higher recurrence risk — consider measuring it before declaring secondary prevention optimised.

Cardiology · Cureus · 2d

Reperfusion Delays in Patients With ST-Segment Elevation Myocardial Infarction: A Prospective Observational Study From a Resource-Limited Setting

Quantifies where minutes are lost between first contact and balloon or lysis in a low-resource Indian centre — audit your own door-to-needle times against these stages.

Cardiology · Cureus · 3d

Early Non-invasive Myocardial Work Indices and Their Association With Adverse Left Ventricular Remodeling Following Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction: A Systematic Review and Meta-Analysis

Lower baseline global constructive work in patients who developed adverse remodeling, but the pooled mean difference was not significant (MD −319.29 mmHg%; 95% CI −671.11 to 32.53), with substantial heterogeneity (I² = 92.9%).

Cardiology · Cureus · 3d

Double Trouble: Myocarditis After Dual Checkpoint Inhibitors

Dual ICI therapy can cause fulminant myocarditis with heart block and shock plus myasthenia overlap; suspect it early in any patient on combination immunotherapy.

Cardiology · Cureus · 3d

Streptococcus anginosus Infective Endocarditis Complicated by a Paravalvular Aortic Abscess in a Patient With a Bicuspid Aortic Valve

In bicuspid valve patients, six weeks of vague constitutional symptoms with embolic infarcts warrants echo before abscess forms — S. anginosus endocarditis is rare but destructive.

Cardiology · Cureus · 3d

Systemic Laboratory Alterations Associated With Heart Failure in Severe Mitral Regurgitation: A Retrospective Observational Study

A post hoc model combining age, sex, C-reactive protein, anemia and eGFR below 60 showed an odds ratio of 5.56 (95% CI 1.94-15.94; P = 0.001) for heart failure; CRP and anemia were not significant after mutual adjustment.

Cardiology · Cureus · 3d

TAVR in Patients with Moderate Aortic Stenosis with At-Risk Features.

If TAVR beats surveillance in moderate AS with at-risk features, the watch-and-wait echo-every-1-2-years approach for these patients may shift toward earlier intervention.

Cardiology · NEJM · 3d

Antithrombotic Therapy After Left Atrial Appendage Occlusion: The SIMPLAAFY Randomized Clinical Trial.

If reduced-dose NOACs or aspirin alone match DAPT after LAAC, you can cut bleeding risk in these often frail, elderly patients without sacrificing device safety.

Cardiology · JAMA · 3d

Life-Saving Intervention Through Real-Time Continuous Cardiac Monitoring: A Case of Tachy-Brady Syndrome Detection and Emergency Management

Persistent AF with 3,199 ventricular pauses, the longest 6.6 seconds and unaccompanied by reported symptoms, plus advanced AV conduction disease and no ventricular tachyarrhythmias — consistent with tachy-brady syndrome

Cardiology · Cureus · 3d

Coronary CT Angiography versus Intravascular Ultrasound Guidance for PCI.

If pre-procedure CCTA matches IVUS guidance for outcomes, you can plan PCI non-invasively and spare patients an extra intracoronary imaging step.

Cardiology · NEJM · 4d

Bilateral Acute Limb Ischaemia Following Myocardial Infarction in a Patient With Left Ventricular Thrombus and Severe Peripheral Arterial Disease

After an MI, new limb pain and pulseless cold legs mean embolisation until proven otherwise — this case shows LV thrombus can throw clot to both limbs within a week.

Cardiology · Cureus · 6d

Selective blockade of microRNA-31-5p-calcitonin receptor interaction reverses established atrial fibrosis and atrial arrhythmia burden.

Targeting miR-31-5p reversed established atrial fibrosis and arrhythmia burden in this model — a first disease-modifying approach for persistent AF, though years from the clinic.

Cardiology · Nature cardiovascular research · 6d

Sacubitril/Valsartan Versus Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Therapy: Rehospitalization Outcomes in a Predominantly Hispanic Population With Heart Failure

Adds real-world rehospitalization data for sacubitril/valsartan in a Hispanic HFrEF cohort, supporting its use where trial populations under-represented this group.

Cardiology · Cureus · 7d

Performance of 0/1 h versus 0/3 h pathways in patients with suspected myocardial infarction: a systematic review and individual participant data meta-analysis of randomised controlled trials.

The 0/1 h pathway discharges more suspected-MI patients safely and faster than 0/3 h, so you can shorten ED stays without missing events.

Cardiology · Lancet · 7d

Temporal proteomics maps concealed-stage remodeling and reveals early mitochondrial alteration as an intervention target in a model of PKP2-arrhythmogenic cardiomyopathy.

In PKP2 mutation carriers, mitochondrial changes appear before any structural disease — a possible window for early intervention, though only in mice so far.

Cardiology · Nature cardiovascular research · 7d

On-Pump Coronary Artery Bypass Grafting With Concomitant Transaortic Left Ventricular Thrombectomy in a Patient With Severe Ischemic Cardiomyopathy and Viable Myocardium: A Case Report

When a mobile LV thrombus coexists with triple-vessel disease, waiting 4-8 weeks for anticoagulation may cost myocardium; combined transaortic thrombectomy at CABG is a feasible single-stage option.

Cardiology · Cureus · 8d

Left Bundle-Branch Area Pacing vs Right Ventricular Pacing for Atrioventricular Block and Preserved Left Ventricular Function: The LEAP-Block Randomized Clinical Trial.

If LBBAP beats RV pacing on heart failure and mortality at 24 months, it changes the default lead target for high-burden pacing in preserved-LV-function AV block.

Cardiology · JAMA · 8d

Active Fire Detections and Hospital Admissions for Circulatory Diseases in Brazil: An Ecological Panel Study (2013-2024)

Adds wildfire smoke to the list of environmental triggers for circulatory admissions — relevant to India's crop-burning and summer fire seasons, though this is ecological, not causal, evidence.

Cardiology · Cureus · 9d

Medical societies release female-specific framework for cardiovascular disease prevention, care

Pregnancy history, menopause timing and autoimmune disease are risk factors your standard ASCVD calculator ignores; this framework tells you where to look.

Cardiology · Fierce Healthcare · 10d

Association of Lipoprotein(a) With Adverse Clinical Outcomes Among Patients With Heart Failure: A Systematic Review and Meta-Analysis

If elevated Lp(a) predicts worse outcomes in established HF, it becomes a cheap, once-in-a-lifetime test worth adding to your HF workup.

Cardiology · Cureus · 10d

Metronidazole-Induced Kounis Syndrome Type III Presenting as Acute In-Stent Thrombosis: A Case Report

A common antibiotic triggered urticaria then in-stent thrombosis 12 hours later; consider Kounis in any stented patient with rash and chest pain.

Cardiology · Cureus · 10d

Concurrent Heparin-Induced and Valproate-Induced Thrombocytopenia Following Transcatheter Aortic Valve Replacement: A Diagnostic Challenge

After TAVR, a falling platelet count has two plausible culprits—heparin and valproate; confirm with serotonin release assay before assuming one, since dual DITP changes anticoagulation and sedation choices.

Cardiology · Cureus · 11d

Sex-Based Differences in Outcomes of Cardiac Resynchronization Therapy in Patients With Left Bundle Branch Block: A Systematic Review and Meta-Analysis

In LBBB-confined cohorts, women appear to gain more from CRT than men — worth weighing when you refer female HFrEF patients for device therapy.

Cardiology · Cureus · 11d

Troponin Elevation in Type 2 Myocardial Infarction: A Systematic Review on Who May Benefit From Coronary Evaluation

A raised troponin in T2MI does not tell you who needs angiography; this review frames which supply-demand patients may actually benefit from coronary evaluation.

Cardiology · Cureus · 11d

Marked QT Prolongation and Torsades de Pointes Following Pulsed Field Ablation for Persistent Atrial Fibrillation

After PFA in a low-EF patient on amiodarone, QT prolonged enough to cause torsades — check post-procedure ECGs and electrolytes in similar high-risk patients.

Cardiology · Cureus · 12d

Concordance Between Trial Efficacy and Real-World Effectiveness of Sodium-Glucose Cotransporter 2 Inhibitors in Heart Failure With Reduced Ejection Fraction: A Systematic Review and Meta-Analysis

Confirms the HFrEF benefit you see in clinic mirrors trial event reductions, so SGLT2 inhibitors deserve routine use in eligible patients rather than cautious selective prescribing.

Cardiology · Cureus · 12d

Very Early-Onset Prosthetic Valve Endocarditis Following Transcatheter Aortic Valve Implantation Complicated by an Aorto-Left Atrial Fistula and Aortic Root Pseudoaneurysm

Endocarditis within 48 hours of TAVI can present with fistula and pseudoaneurysm, so keep it on the differential when a post-TAVI patient deteriorates early.

Cardiology · Cureus · 13d

Artificial Intelligence for Automated Continuous Quantification of Left Ventricular Ejection Fraction From Standard Adult Transthoracic Echocardiography: A Systematic Review

Before trusting an automated EF, know that agreement with reference varies across AI tools — verify against your own lab's values rather than adopting a single vendor number.

Cardiology · Cureus · 13d

Extending the Lower Limits of Body Weight for Bi-directional Glenn Shunt in Developing Countries: Is it Feasible?

Suggests a 2.7 kg infant can undergo BDG shunting in resource-limited settings, supporting earlier palliation rather than waiting for weight gain that may never come.

Cardiology · Cureus · 14d

Real-World Positivity, Procedural Events, and Management Changes After Intravenous Methylergometrine Provocation Testing for Coronary Vasospasm: A Single-Center Study of 139 Patients

If you use IV ergonovine testing for vasospasm, this gives contemporary positivity and procedural-event rates to weigh against the acetylcholine reference standard.

Cardiology · Cureus · 21 Oct

Diagnosis and Treatment of Cardiovascular Conditions in Medicare Advantage In-Home Health Risk Assessments.

Home risk assessments diagnose more cardiovascular disease in Medicare Advantage patients; know whether this drives real treatment or just higher risk-adjusted payments.

Cardiology · Annals · 20 Oct

A Common CD36 Variant and the Genetic Landscape of Dilated Cardiomyopathy in Individuals of African Ancestry.

A common CD36 variant may explain part of the excess familial DCM in patients of African ancestry, so consider genetic referral when DCM clusters in such families.

Cardiology · JAMA · 19 Oct

Treatment Strategies for Achieving and Maintaining Low-Risk Status in Pulmonary Arterial Hypertension: A Systematic Review

Few patients reached low risk under any strategy, and fewer than half did so after upfront dual oral therapy in most cohorts. Low-risk status predicted survival but often did not last.

Cardiology · Cureus · 19 Oct

The Safety and Efficacy of Intravascular Lithotripsy in Treating Calcified Peripheral Arterial Disease

IVL showed a good safety profile with a low complication rate and was more effective than plain balloon angioplasty alone in calcified PAD; short- and mid-term results are promising.

Cardiology · Cureus · 18 Oct