Archive

Advances in the management of renal cell carcinoma.

Molecular subtyping now refines RCC diagnosis beyond histology, so imaging and selective biopsy decisions increasingly depend on tumour biology rather than stage alone.

Oncology · BMJ · 11d

Izalontamab brengitecan versus platinum-based chemotherapy in EGFR-mutated advanced non-squamous non-small-cell lung cancer after progression on third-generation EGFR tyrosine kinase inhibitors (PANKU-Lung01): a multicentre, randomised, open-label, phase 3 trial in China.

Median BICR-assessed progression-free survival 11·1 months (9·2-12·7) with iza-bren versus 5·7 months (5·5-5·9) with chemotherapy; HR 0·40 (95% CI 0·31-0·51), one-sided p<0·0001.

Oncology · Lancet · 11d

First-line pembrolizumab versus carboplatin plus paclitaxel in participants with mismatch repair-deficient advanced or recurrent endometrial cancer (KEYNOTE-C93/GOG-3064/ENGOT-en15): interim analysis of a multicentre, open-label, randomised, active-comparator controlled, phase 3 trial.

Median progression-free survival 38·2 months versus 8·4 months (HR 0·57, 95% CI 0·42-0·79; p=0·0002). Overall survival interim criterion not met (HR 0·77, 95% CI 0·52-1·15; p=0·10). Grade 3+ treatment-related events 18% versus 51%.

Oncology · Lancet · 11d

Reversible Stress Cardiomyopathy and Suspected Neuroleptic Malignant Syndrome Following Clozapine Withdrawal: A Case Report

Severe left ventricular systolic impairment with apical akinesis and basal hypercontractility, elevated troponin, rising creatine kinase and new rigidity; all resolved with supportive care alone, without specific NMS treatment

Psychiatry · Cureus · 11d

First Description of Intermediate Component Separation: A Novel Compartment-Preserving Technique for Medium and Large Incisional Hernia Repair

A compartment-preserving mesh technique for medium-to-large incisional hernias may reduce dissection-related morbidity, but this is a first description without outcome data to guide adoption yet.

General Surgery · Cureus · 11d

Spontaneous Tumor Lysis Syndrome in a Critically Ill Patient With Cytology Favoring Small Cell Carcinoma: A Case Report

Uric acid rose to a documented peak of 12 mg/dL and LDH reached 3,608 U/L, with progressive hyperkalemia, hyperphosphatemia, hypocalcemia, acidosis and anuria; she died of refractory shock and multiorgan failure

Oncology · Cureus · 11d

Contemporary Management of Colorectal Liver Metastases

Resectability is no longer the sole gate: molecular profile and functional liver reserve now decide whether your CRLM patient goes straight to surgery or to conversion therapy first.

Oncology · Cureus · 11d

Concurrent Heparin-Induced and Valproate-Induced Thrombocytopenia Following Transcatheter Aortic Valve Replacement: A Diagnostic Challenge

After TAVR, a falling platelet count has two plausible culprits—heparin and valproate; confirm with serotonin release assay before assuming one, since dual DITP changes anticoagulation and sedation choices.

Cardiology · Cureus · 11d

One in four tribal adults in Odisha has impaired kidney function: ICMR study

A quarter of 19,703 tribal adults screened had impaired kidney function, so consider eGFR testing in Adivasi patients from these 14 districts rather than waiting for symptoms.

General Medicine · ETHealthworld · 11d

Artificial Intelligence-Supported Learning and Its Effect on Knowledge Acquisition and Practical Performance Among Nursing Students: A Systematic Review and Meta-Analysis

Knowledge findings were too inconsistent to pool: one study showed a very large benefit for a purpose-built chatbot, another showed no clear difference. No study assessed observed clinical performance; one general-purpose language model produced poorer rubric-scored work than textbook learning.

Medicine · Cureus · 11d

Non-prescription Antibiotic Dispensing in Community Pharmacies of Islamabad Capital Territory, Pakistan: A Simulated Client Study

Simulated clients were readily sold antibiotics without prescriptions in Islamabad, so assume patients arrive already partially treated and counsel on completing prescribed courses.

General Medicine · Cureus · 11d

When a Contaminant Is Not a Contaminant: A Case Report of Micrococcus luteus Causing Septic Shock in the Absence of Traditional Risk Factors

Multiple blood cultures grew M. luteus, confirming true bacteremia rather than contamination; she required fluid resuscitation, vasopressors and intravenous antibiotics, then improved with clearance of bacteremia.

General Medicine · Cureus · 11d

Patient- and Operator-Related Factors Associated With Difficult Lumbar Epidural Catheter Placement: A Retrospective Observational Study

Knowing which patient and operator factors predict needing two or more skin punctures lets you anticipate a difficult lumbar epidural and plan analgesia accordingly.

Anaesthesiology · Cureus · 11d

When a Burn Scar Invades the Brain: A Case Report of Advanced Marjolin Ulcer of the Scalp

Any non-healing ulcer on an old burn scar warrants biopsy, not dressing — this one eroded through scalp into brain 33 years after a childhood injury.

General Surgery · Cureus · 11d

Small Bowel Perforation and Subsequent Pleural Effusion Following Operative Hysteroscopy: A Case Report

Persistent abdominal pain and peritonism after hysteroscopy can signal bowel injury, not just uterine perforation — CT early, since stable vitals do not exclude it.

Obstetrics & Gynaecology · Cureus · 11d

Sex-Based Differences in Outcomes of Cardiac Resynchronization Therapy in Patients With Left Bundle Branch Block: A Systematic Review and Meta-Analysis

In LBBB-confined cohorts, women appear to gain more from CRT than men — worth weighing when you refer female HFrEF patients for device therapy.

Cardiology · Cureus · 11d

Clarithromycin-Associated Carbamazepine Toxicity Presenting as a Posterior Circulation Stroke Mimic

Serum carbamazepine was 18.6 mg/L and sodium 122 mmol/L, down from a baseline of approximately 130 mmol/L. Symptoms resolved within 48 hours of withholding carbamazepine and correcting hypovolaemia.

Neurology · Cureus · 11d

Troponin Elevation in Type 2 Myocardial Infarction: A Systematic Review on Who May Benefit From Coronary Evaluation

A raised troponin in T2MI does not tell you who needs angiography; this review frames which supply-demand patients may actually benefit from coronary evaluation.

Cardiology · Cureus · 11d

Reconstructive Strategies in Acute Nasal Soft-Tissue Trauma: A Narrative Review and Subunit-Based Algorithm

Gives you a subunit-based framework for timing and salvage decisions in acute nasal trauma, where contamination and tissue viability make oncologic algorithms unreliable.

General Surgery · Cureus · 11d

Invasive Infection Associated With Probiotics in Adults: Does the Pathogen Originate From the Product or the Host Intestine?

Before prescribing probiotics to ICU or immunocompromised patients, note that strain-level typing is needed to tell product-derived bacteremia from the patient's own flora.

General Medicine · Cureus · 11d

Pulmonary Embolism With Pulmonary Infarction Despite Low-Risk Prediction Scores: Atypical Pleuritic, Abdominal, and Shoulder Pain

PERC, Wells and Geneva scores all indicated low pretest probability despite CT angiography confirming subsegmental PE with pulmonary infarction; D-dimer was near-threshold

General Medicine · Cureus · 12d

Divarasib as Compared with Sotorasib or Adagrasib in KRAS G12C-Mutated NSCLC.

A next-generation KRAS G12C inhibitor beat sotorasib/adagrasib head-to-head in previously treated NSCLC — expect divarasib to enter your second-line sequencing decisions.

Oncology · NEJM · 12d

Sacituzumab Tirumotecan plus Pembrolizumab in PD-L1-Negative Advanced NSCLC.

If the combination beats pembrolizumab-chemotherapy in PD-L1-negative NSCLC, it offers a chemotherapy-sparing first-line option for a group with few good choices.

Oncology · NEJM · 12d

Osimertinib-Savolitinib in Advanced NSCLC after Progression during EGFR-TKI Therapy.

For EGFR-mutant NSCLC progressing on osimertinib, adding a MET inhibitor targets the commonest resistance mechanism — but requires confirming MET amplification or overexpression first.

Oncology · NEJM · 12d

Stratified Outpatient Management and Radiological Follow-Up After Endovascular Treatment for Unruptured Intracranial Aneurysms

A risk-stratified follow-up schedule after unruptured aneurysm coiling could cut routine imaging visits for stable patients while keeping closer watch on higher-risk anatomy.

Neurology · Cureus · 12d

Artificial Intelligence for the Verification of Nasogastric Tube Position in Chest Radiographs: A Systematic Review

If validated, AI triage of NGT position on chest films could cut the delay and missed malposition that make this a recurring patient-safety failure on wards.

Radiology · Cureus · 12d

Comparison of Acute Hematological Toxicities Between Three-Dimensional Conformal Radiotherapy (3DCRT) and Intensity-Modulated Radiotherapy (IMRT) in Locally Advanced Cervical Cancer

During EBRT, overall haematological toxicity was 97.14% with 3DCRT versus 77.14% with IMRT (p = 0.012); leukopenia 65% versus 34% (p = 0.05). After ICRT, overall toxicity 97.14% versus 71.43% (p = 0.006) and anaemia 85.7% versus 51.4% (p = 0.002).

Oncology · Cureus · 12d

Age- and Sex-Specific Distribution of Vascular and Behavioural Risk Factors Among Patients With Acute Ischaemic Stroke: A Hospital-Based Study From North India

Dyslipidaemia 56.2%, hypertension 55.4%, diabetes 55.1%. Hypertension and dyslipidaemia rose with age (both p<0.001). RHD was more common in females (15.0% vs 6.1%, p=0.010); combined CAD/RHD 50.3% vs 38.9% (p=0.044).

Neurology · Cureus · 12d

Comparison of Nifedipine Versus Nitroglycerin Patch in the Management of Preterm Labor: A Prospective Comparative Cohort Study

Supports oral nifedipine as first-line tocolysis, buying the 48 hours needed for steroids and referral without relying on a patch.

Obstetrics & Gynaecology · Cureus · 12d

Comparative Clinical Outcomes of Fractional CO₂ Laser-Assisted Topical Therapy for Nail Psoriasis: A Systematic Review

Direct comparative effects were inconsistent across studies and varied by topical agent, comparator and assessment time. Advantages appeared in selected tazarotene and methotrexate comparisons; other comparisons showed no clear incremental benefit. Meta-analysis was not possible due to heterogeneity.

General Medicine · Cureus · 12d

Visceral Leishmaniasis Presenting as Hemophagocytic Lymphohistiocytosis in a Non-endemic Setting: A Case Report

HLH features prompted anakinra and corticosteroids; VL was then confirmed by serology, PCR and histopathology, and liposomal amphotericin B produced rapid clinical improvement

General Medicine · Cureus · 12d

Marked QT Prolongation and Torsades de Pointes Following Pulsed Field Ablation for Persistent Atrial Fibrillation

After PFA in a low-EF patient on amiodarone, QT prolonged enough to cause torsades — check post-procedure ECGs and electrolytes in similar high-risk patients.

Cardiology · Cureus · 12d

Concordance Between Trial Efficacy and Real-World Effectiveness of Sodium-Glucose Cotransporter 2 Inhibitors in Heart Failure With Reduced Ejection Fraction: A Systematic Review and Meta-Analysis

Confirms the HFrEF benefit you see in clinic mirrors trial event reductions, so SGLT2 inhibitors deserve routine use in eligible patients rather than cautious selective prescribing.

Cardiology · Cureus · 12d

Species Distribution and Antifungal Susceptibility of Candida Bloodstream Isolates in Children: A Three-Year Study From North India

Non-albicans Candida now dominates paediatric bloodstream infections here, so empiric antifungal choice in a sick neonate should follow local susceptibility, not albicans-era habits.

Paediatrics · Cureus · 12d

Small Bowel Obstruction Temporally Associated With an Unsupervised Transition From Tirzepatide to Semaglutide After a Prolonged Treatment Interruption: A Case Report

Ask patients on GLP-1 agonists who stopped and restarted, or switched agents, whether they re-titrated — resuming at a prior dose can precipitate obstruction.

Gastroenterology · Cureus · 13d

Anbenitamab plus HB1801 for HER2-Positive Advanced Breast Cancer.

A HER2 bispecific plus albumin-bound docetaxel may offer a first-line alternative to THP, but wait for the survival and toxicity data before switching regimens.

Oncology · NEJM · 13d

Durvalumab, Tremelimumab, and Enfortumab Vedotin in Muscle-Invasive Bladder Cancer.

If perioperative durvalumab plus neoadjuvant enfortumab vedotin improves outcomes in cisplatin-ineligible patients, it reshapes who you can offer bladder-sparing curative-intent therapy to.

Oncology · NEJM · 13d

Relatlimab plus nivolumab versus nivolumab for advanced melanoma: 5-year survival and biomarker analyses of the phase 3 RELATIVITY-047 trial.

Five-year data confirm the fixed-dose relatlimab-nivolumab combination's durable survival benefit over nivolumab alone, supporting it as a first-line option in untreated advanced melanoma.

Oncology · Nature Medicine · 13d

Sodium-Glucose Cotransporter 2 Inhibitor Use and Levels of Hemoglobin, Markers of Iron Metabolism, and Erythropoiesis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Explains the small but consistent hemoglobin rise on SGLT2 inhibitors — useful when interpreting falling or stable counts in diabetic and heart-failure patients already on these drugs.

Endocrinology · JAMA · 13d

Neoadjuvant nivolumab with or without visugromab in muscle-invasive bladder cancer: the phase 2a GDFATHER-NEO trial.

Adds a GDF-15 antibody to neoadjuvant nivolumab in MIBC; check the pathological response and toxicity data before considering this combination for cisplatin-ineligible patients.

Oncology · Nature Medicine · 13d