Archive

Inequality is major factor in impact of non-communicable diseases: WHO

Your NCD patients' outcomes depend as much on their income and locality as on the drug you prescribe, so screening and follow-up need to target the most disadvantaged groups.

General Medicine · ETHealthworld · 21 Oct

Diagnostic Performance and Limitations of Routine Vital Signs and Early Warning Scores in Postpartum Maternal Sepsis: A Systematic Review

Routine vitals and shock index miss postpartum sepsis because normal delivery physiology mimics it — don't rely on early warning scores alone to rule it out.

Obstetrics & Gynaecology · Cureus · 21 Oct

Global and regional burden of measles and vaccine coverage among children under 5 years, 1990-2023: a Global Burden of Disease Study.

Stagnant coverage is translating into real under-5 measles deaths again — check and catch up on missed MMR doses in your paediatric patients.

Paediatrics · Nature Medicine · 21 Oct

Global, regional and national burden of pertussis in 1990-2023: a Global Burden of Disease study.

Pertussis still kills infants despite routine immunisation, so keep it high in the differential for any young infant with paroxysmal cough or apnoea, and check maternal and infant vaccine status.

Paediatrics · Nature Medicine · 21 Oct

Endometrial ablation plus levonorgestrel-releasing intrauterine system versus endometrial ablation alone in women with heavy menstrual bleeding in The Netherlands (MIRA2): a multicentre, open-label, randomised, controlled, superiority trial.

If adding an LNG-IUS at ablation cuts repeat surgery and hysterectomy, it is a cheap change you can make in the same sitting.

Obstetrics & Gynaecology · Lancet · 21 Oct

Childhood Cancer Risk After Assisted Reproductive Technology.

In over a million Danish children, ART conception carried no meaningful excess childhood cancer risk overall, so you can reassure IVF parents rather than add cancer to their worry list.

Obstetrics & Gynaecology · JAMA · 21 Oct

Acetic acid chromoendoscopy for detection of neoplastic Barrett's oesophagus: stepped wedge cluster randomised controlled trial (ACID-trial).

If AAC improves dysplasia detection in community surveillance, it is a cheap, widely available adjunct you could add to standard Seattle-protocol biopsies without new equipment.

Gastroenterology · BMJ · 21 Oct

Retatrutide Once Weekly for Treatment of Obstructive Sleep Apnea.

A triple agonist injection may cut OSA severity in patients who cannot tolerate CPAP — worth knowing before patients ask about it.

Endocrinology · NEJM · 21 Oct

Disease-free survival and overall survival after neoadjuvant immunotherapy in mismatch repair-deficient colon cancer in the Netherlands: results of the single-arm, multicentre, phase 2, NICHE-2 trial.

3-year disease-free survival was 100% (97·5% CI 100-100) and 5-year overall survival 100% (95% CI 100-100) at median postoperative follow-up of 58·7 months.

Oncology · Lancet · 21 Oct

Obesity in Children Aged 2 to 12 Years: A Review.

Intensive health behaviour and lifestyle treatment reduced BMI by 0.7 versus non-participation. In one randomised trial in children aged 6 to under 12, liraglutide reduced BMI by 7.4% versus placebo. Setmelanotide is approved only for rare monogenic and syndromic obesity.

Paediatrics · JAMA · 21 Oct

Culture-Negative Cystitis With Multiorgan Dysfunction and Septic Shock After Intravesical Bacillus Calmette-Guérin (BCG) Therapy: A Case Report and Review of the Literature

Progression to multiorgan failure and death over a four-week hospitalization; antimycobacterial agents and corticosteroids were not started until day 12, with microbiological data negative.

Urology · Cureus · 21 Oct

Epic launches Connectors to link its AI tools with third-party apps

If your hospital runs Epic, third-party tools will soon plug into its AI agents, so expect new app-integration requests and data-governance questions at your next IT committee.

Medicine · Fierce Healthcare · 21 Oct

Short-Course Preoperative Breast Radiotherapy: A Strategy to Reduce Financial Toxicity in Early-Stage Breast Cancer

No primary outcome reported. Five-fraction APBI is described as economically advantageous yet underutilised; whether preoperative radiotherapy reduces financial toxicity remains uncertain, and the institutional savings estimate is unpublished and not validated by time-driven activity-based costing

Oncology · Cureus · 21 Oct

FDA Approves First-of-Its-Kind Chronic Hepatitis B Treatment

A first-in-class antisense drug that may clear HBsAg in non-cirrhotic chronic HBV, offering a functional-cure pathway beyond lifelong nucleoside suppression.

Gastroenterology · FDA — Press Announcements · 21 Oct

Anticoagulation Monitoring in Recurrent Venous Thromboembolism Associated With Antiphospholipid Antibodies and Subsequent Heparin-Induced Thrombocytopenia

In triple-positive antiphospholipid patients, baseline aPTT and INR are uninterpretable — a prolonged aPTT before any heparin can mask or mimic HIT, so use paired samples and functional assays.

General Medicine · Cureus · 21 Oct

Real-World Positivity, Procedural Events, and Management Changes After Intravenous Methylergometrine Provocation Testing for Coronary Vasospasm: A Single-Center Study of 139 Patients

If you use IV ergonovine testing for vasospasm, this gives contemporary positivity and procedural-event rates to weigh against the acetylcholine reference standard.

Cardiology · Cureus · 21 Oct

When Hydronephrosis Was Not Physiological: A Case of Septic Shock Secondary to Obstructive Uropathy in Pregnancy

Physiological hydronephrosis in pregnancy can mask true obstruction — treat worsening loin pain as possible urosepsis and escalate early for imaging and decompression.

Obstetrics & Gynaecology · Cureus · 20 Oct

Myocardial Infarction in a Patient With Chronic Lymphocytic Leukemia: Acalabrutinib-Related Dehoming as a Potential Culprit

STEMI occurred 28 days after acalabrutinib initiation, with absolute lymphocyte count 261 x 109/L on admission. Course included cardiac arrest, third-degree AV block needing temporary pacing, PCI with IABP, and parietal and occipital strokes; she was discharged home.

Oncology · Cureus · 20 Oct

Focal Versus Whole-Gland Cryoablation Therapy in High-Grade Prostate Cancer: A Single-Institution Retrospective Study

Adds single-institution bRFS data for focal versus whole-gland cryoablation in high-risk prostate cancer, a group where you rarely have trial evidence to guide local therapy choice.

Urology · Cureus · 20 Oct

FDA Approves Once-Weekly Generic Hormone Therapy Patch for Women

A cheaper once-weekly estradiol-levonorgestrel patch gives your menopausal patients with an intact uterus a lower-cost option without changing dosing or endometrial protection.

Obstetrics & Gynaecology · FDA — Press Announcements · 20 Oct

Comparison of Two Polypropylene Meshes With Different Areal Densities in Open Lichtenstein Repair of Primary Inguinal Hernia: A Prospective, Quasi-Randomized Controlled Trial

VAS pain was lower with ultralightweight mesh on POD 1 (2.90 ± 0.81 vs 4.72 ± 1.18; mean difference -1.82, 95% CI -2.27 to -1.38) and at one and six weeks, but converged by six months and one year. Chronic pain 0% vs 7.5% (p=0.239).

General Surgery · Cureus · 20 Oct

Vitamin B6 Doses on United States Dietary Supplement Labels Relative to the Tolerable Upper Intake Level: A Census of the National Institutes of Health Dietary Supplement Label Database

Ask patients on high-dose B6 about tingling or numbness — supplement labels often exceed the 100 mg/day UL that causes peripheral neuropathy.

Neurology · Cureus · 20 Oct

STAT+: OpenEvidence’s JAMA paper leaves open questions

Describes how clinicians actually query an AI answer engine at the point of care, but leaves accuracy and safety unmeasured — read before adopting it in your OPD.

General Medicine · STAT News — Health Tech · 20 Oct

Postoperative Radial Nerve Palsy After Surgical Fixation of Humeral Shaft Fractures: A Systematic Review of Management and Functional Outcomes

Postoperative radial nerve palsy occurred across the included studies and neurological recovery was generally favourable, though recovery frequently required several months; incidence estimates varied with the population at risk and the definition used

Orthopaedics · Cureus · 20 Oct

Universal Versus Selective Sampling of Umbilical Cord Gases in University-Based, Academic Community-Based, and Private Practice Settings: A Cross-Sectional Study

Universal cord gas sampling gives you objective fetal metabolic status at delivery, but practice varies by setting — know whether your unit's selective policy could miss hypoxic-ischemic events.

Obstetrics & Gynaecology · Cureus · 20 Oct

Standalone Complete Decongestive Therapy Versus Combined Treatment With Kinesio Taping for Reducing Upper Limb Breast Cancer-Related Lymphedema After Axillary Dissection: A Randomized Clinical Trial

Adding kinesio taping to decongestive therapy was tested against CDT alone in 40 post-axillary-dissection women — know whether the extra taping buys measurable limb volume before you refer.

Oncology · Cureus · 20 Oct

Artificial Intelligence Versus Logistic Regression for Postoperative Mortality Prediction: A Systematic Review and Meta-Analysis

Before trusting an AI risk score in your preop clinic, note this meta-analysis finds no clear discrimination advantage over logistic regression for postoperative mortality.

Anaesthesiology · Cureus · 20 Oct

FDA Issues Final Guidance on Prescription Drug Apps and Software

Drug-company apps you or your patients use alongside a prescription now have a defined FDA framework, so expect clearer labelling and accountability for what these tools claim.

General Medicine · FDA — Press Announcements · 20 Oct

Patient-Reported Outcomes and Disease-Specific Quality of Life After Surgical and Conservative Treatments for Lower Limb Varicose Veins: A Systematic Review

When patients ask whether stripping or endovenous ablation is worth it, this review frames the choice around symptom burden and disease-specific QoL, not just vein closure.

General Surgery · Cureus · 20 Oct

Vestibular Epilepsy Presenting With Isolated Recurrent Vertigo and Postictal Headache: A Case Report

Before labelling brief recurrent vertigo as vestibular migraine or BPPV, consider vestibular epilepsy — postictal headache and one-to-two-minute attacks are the clues, and no diagnostic criteria exist yet.

Neurology · Cureus · 20 Oct

Evaluating Perceptions of AI-Simulated Patients as an Adjunct to Peer-Based Clinical Case Practice in Undergraduate Medical Education: A Mixed Methods Survey Study

If AI patient simulators are acceptable to students, they could give unlimited consultation practice without faculty time — relevant if you teach or supervise trainees.

General Medicine · Cureus · 20 Oct

Swallowing-Induced Neck Bulging and Internal Jugular Vein Distension in Omohyoid Muscle Syndrome

A transient swallow-related neck bulge with normal resting imaging should prompt dynamic assessment for omohyoid syndrome rather than reassurance or unnecessary workup.

General Surgery · Cureus · 20 Oct

Primary Aortoduodenal Fistula: A Case Report and Recent Literature Review (2021-2025)

In obscure GI bleeding with a known aortic aneurysm, keep PADF on the differential — endoscopy often misses it, and delay is fatal.

Gastroenterology · Cureus · 20 Oct

Seizure-Onset Intracerebral Hemorrhage of Undetermined Etiology in a Child: Anesthetic, Intensive Care, and Rehabilitation Management

A child with new seizures and altered consciousness may have a hemorrhagic stroke, not meningitis or metabolic illness; imaging early and involve anaesthesia and rehab teams.

Paediatrics · Cureus · 20 Oct

Ocular Outcomes of Glucagon-Like Peptide-1 Receptor Agonists Versus Sodium-Glucose Cotransporter-2 Inhibitors in Type 2 Diabetes: A Systematic Review and Meta-Analysis of Real-World Evidence

When choosing between a GLP-1 RA and an SGLT2 inhibitor for a patient with diabetes, this pooled real-world comparison tells you whether their retinopathy risk differs.

Ophthalmology · Cureus · 20 Oct

Effect of Vestibular Stimulation Exercises on the Level of Consciousness in Patients With Intracerebral Hemorrhage: A Systematic Review

Graded vestibular exercises may be a cheap bedside adjunct to multisensory stimulation for ICH survivors with low consciousness, but this review's evidence is early and needs confirmation before routine use.

Neurology · Cureus · 20 Oct

Diabetic Retinal Disease Onset and Progression During Established Semaglutide or Tirzepatide Treatment: A Retrospective Comparative Cohort Study With a Descriptive Regional Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Review

If semaglutide or tirzepatide users show different retinal disease progression, your diabetic patients on these drugs need documented baseline fundus exams and scheduled follow-up.

Ophthalmology · Cureus · 20 Oct

Diagnosis and Treatment of Cardiovascular Conditions in Medicare Advantage In-Home Health Risk Assessments.

Home risk assessments diagnose more cardiovascular disease in Medicare Advantage patients; know whether this drives real treatment or just higher risk-adjusted payments.

Cardiology · Annals · 20 Oct

Overuse and False Restraint in Large Language Model Recommendations for Choosing Wisely Scenarios.

If you use an LLM for test-ordering advice, it both over-investigates and wrongly withholds appropriate care — verify its restraint calls against the actual Choosing Wisely caveats.

General Medicine · Annals · 20 Oct

Projected Effect of 2026 Federal Changes to the Childhood Immunization Schedule on Chronic Hepatitis B Virus Infections in the United States.

Modelling shows dropping birth-dose HBV vaccination would raise chronic infections in newborns — relevant if you counsel parents or advise on catch-up schedules.

Paediatrics · Annals · 20 Oct