Archive

Manganese Deposition Encephalopathy Associated With Prolonged Total Parenteral Nutrition: A Case Report

In patients on prolonged TPN with cholestasis, unexplained parkinsonism or MRI basal ganglia changes should prompt consideration of manganese toxicity from parenteral nutrition.

Neurology · Cureus · 1 Oct

Blueberry Muffin Sign: A Diagnostic Histochemical Clue in Mitochondrial Myopathy

In unexplained bilateral ptosis with ophthalmoplegia, requesting the blueberry muffin histochemical stain on muscle biopsy can confirm mitochondrial myopathy and end a decades-long diagnostic odyssey.

Neurology · Cureus · 30 Sept

Standalone Middle Meningeal Artery Embolization Versus Surgical Evacuation for Nontraumatic Subdural Hematoma: A Propensity-Matched Multicenter Real-World Study

Propensity-matched real-world data suggest standalone MMA embolization may rival surgical evacuation in nontraumatic subdural hematoma, supporting a less invasive option in frail or recurrent cases.

Neurology · Cureus · 30 Sept

CSIR-CCMB study describes how viral infection may pave way for Parkinson's disease

Adds viral infection to the differential for Parkinson's risk, suggesting post-encephalitic patients may warrant closer neurological follow-up.

Neurology · ETHealthworld · 30 Sept

Mechanistic Differences in Adult-Onset and Juvenile-Onset Huntington’s Disease and the Potential Role of Neurodevelopment

Juvenile-onset Huntington's may reflect disrupted circuit maturation rather than pure degeneration, which could mean different timing and targets for intervention in younger patients.

Neurology · Cureus · 30 Sept

Predictors of Postoperative Neurological Outcome After Surgical Evacuation of Traumatic Acute Subdural Hematoma: A Retrospective Cohort Study

Unfavorable outcome occurred in 74 (61.7%) and mortality was 21.7% (26/120). Independent predictors included GCS ≤8 (aOR 4.86), bilateral non-reactive pupils (aOR 4.10), and hypotension (aOR 2.79).

Neurology · Cureus · 30 Sept

A Care-Level-Stratified Algorithm for Neuromodulation in Persistent Spinal Pain Syndrome Type 2: Critical Appraisal of Contemporary Evidence Adapted to Latin American Health Systems

Offers a tiered pathway for post-laminectomy pain, helping you decide when to escalate from medical therapy to spinal cord stimulation in resource-limited settings.

Neurology · Cureus · 29 Sept

Subependymal Giant Cell Astrocytoma Mimicking Recurrent Ependymoma: Imaging Clues to the Diagnosis of Tuberous Sclerosis Complex

In a child with prior ependymoma, a new intraventricular mass may be TSC-related SEGA, not recurrence; imaging clues can spare unnecessary reoperation.

Neurology · Cureus · 29 Sept

Atypical Presentation of a Meningioma Masquerading as Trigeminal Neuralgia: A Diagnostic Challenge in the Emergency Department

Atypical features (prolonged sensory loss, proptosis, diplopia) prompted imaging; CT showed a sclerotic sphenoid lesion, MRI revealed a large en plaque meningioma with orbital extension and optic nerve compression, plus a separate right cerebellopontine angle meningioma.

Neurology · Cureus · 28 Sept

Temporal Trends and Demographic Contributions to Stroke Burden in India, 1990–2023: An Analysis of Global Burden of Disease 2023 Estimates Using Shapley Decomposition and Joinpoint Regression

Incident cases rose from 0.73 million to 1.87 million (155.1%), deaths from 0.42 million to 1.03 million (148.2%), DALYs from 12.41 million to 25.99 million (109.4%). Age-standardised incidence stable; mortality and DALY rates declined.

Neurology · Cureus · 28 Sept

Factors Associated With Recurrence in Patients With Benign Paroxysmal Positional Vertigo Following Canal Repositioning Therapy

Recurrence after repositioning is common, so identifying which BPPV patients need closer follow-up and explicit counselling about relapse risk can reduce repeat ED visits.

Neurology · Cureus · 28 Sept

Atomoxetine for Orthostatic Hypotension in Traumatic and Non-traumatic Spinal Cord Injury: A Case Series From a Neuro-Rehabilitation Setting

When midodrine and fludrocortisone fail in spinal cord injury, atomoxetine may restore blood pressure enough for patients to tolerate rehabilitation sessions.

Neurology · Cureus · 27 Sept

Recurrent Pneumococcal Meningitis Without Cerebrospinal Fluid Pleocytosis and With Fulminant Septic Shock: A Case Report

CSF showed no findings strongly suggestive of meningitis; cultures from blood, urine and CSF grew Streptococcus pneumoniae only the day after death, which occurred on the day of admission

Neurology · Cureus · 26 Sept

Sudden Onset Occipital Headache as a Presenting Feature of Ischaemic Stroke

MRI showed a 3.5 cm acute right occipital infarct; CT was normal. Formal perimetry revealed a left superior homonymous quadrantanopia missed on bedside confrontation.

Neurology · Cureus · 25 Sept

Stroke Mimics in a Tertiary Comprehensive Stroke Center: Implications for Healthcare Provider Education

True strokes were 35.1% (221/630); mimics 64.9% (409/630). Leading mimics: sepsis 5.7%, migraine 4.6%, seizure 3.3%, subdural hematoma 3.3%, hypertensive emergency 3.3%.

Neurology · Cureus · 25 Sept

Why Seizures Break Through: Distinguishing Background Susceptibility From Proximal Precipitants in Patients With Epilepsy

Distinguishing a patient's baseline seizure susceptibility from an immediate trigger like missed doses or sleep loss changes whether you reassure, adjust ASM, or investigate.

Neurology · Cureus · 25 Sept

Radiotherapy versus observation following surgical resection of WHO grade 2 atypical meningioma (ROAM/EORTC-1308): an international, multicentre, open-label, phase 3, randomised controlled trial.

After complete resection of grade 2 meningioma, adjuvant radiotherapy delays recurrence but does not improve overall survival, so timing and patient selection matter more than routine referral.

Neurology · Lancet · 25 Sept

Automated Tractography of Corticospinal and Corticoreticular Projections Originating From Brodmann Area 44 in Patients With Mild Stroke

FA was lower in the lesioned hemisphere for both BA44-origin corticospinal projections (0.484 vs 0.508, P = 0.011) and corticoreticular projections (0.442 vs 0.463, P = 0.049).

Neurology · Cureus · 25 Sept

Not All Brain Bleeds Are Equal: An Etiology-First Framework for Stroke Prevention After Intracerebral Hemorrhage

Before restarting a DOAC after ICH, weigh the bleed's cause: lobar amyloid bleeds recur more than deep hypertensive ones, so the anticoagulation decision should differ.

Neurology · Cureus · 24 Sept

Acadia misses mark in Alzheimer’s but concludes phase 3 ‘absolutely worth’ pursuing

A negative phase 2 in Alzheimer's still advancing to phase 3 signals the endpoint may be wrong, not the drug — wait for phase 3 before discussing this with patients.

Neurology · Fierce Biotech · 24 Sept

Recurrent Ischemic Stroke Despite Dabigatran Therapy: Unexpectedly Low Anti-IIa Activity Revealing Pharmacokinetic Treatment Failure

If a patient strokes on dabigatran, measure anti-IIa activity rather than assuming non-adherence — confirmed low levels may mean switching anticoagulant.

Neurology · Cureus · 23 Sept

Tenecteplase Before Thrombectomy at 4.5 to 24 Hours for Basilar Artery Occlusion: The ATTENTION LATE Randomized Clinical Trial.

If bridging tenecteplase improves outcomes in late-presenting basilar occlusion, it changes your thrombolysis decision for posterior-circulation strokes beyond the 4.5-hour window.

Neurology · JAMA · 23 Sept

AI-based characterization of Alzheimer's disease phenotypes from population-scale single-cell data.

Explains why Alzheimer's patients differ in psychosis and cognitive decline, pointing toward phenotype-specific targets rather than one-size-fits-all treatment.

Neurology · Nature Medicine · 23 Sept

Impact of Premorbid Function and Comorbidities in Geriatric Traumatic Brain Injury Patients: A Systematic Review

In TBI patients over 60, baseline frailty and comorbidity predict mortality and recovery better than age alone, so weigh premorbid function when discussing prognosis and goals of care.

Neurology · Cureus · 23 Sept

Radiological Correlates of Headache and Papilledema in Patients Undergoing Cranial MRI: Clinical Relevance of the Evans Index and Fazekas Score

Incidental ventriculomegaly or white-matter changes on MRI may not explain your patient's headache or papilledema, so don't anchor the workup on these scores alone.

Neurology · Cureus · 22 Sept

Otsuka heads to FDA as Ionis-partnered ALS drug hits primary phase 3 endpoint

A positive phase 3 in ALS gives your patients a new disease-modifying option and a likely expedited FDA pathway to access it.

Neurology · Fierce Biotech · 22 Sept

Traumatic Macroglossia Associated With Clustered Epileptic Seizures in a Patient With Down Syndrome

In drug-resistant epilepsy with seizure clusters, tongue biting can cause macroglossia and acute airway obstruction; watch for tongue swelling after clustered tonic seizures.

Neurology · Cureus · 22 Sept

Anaconda Biomed snares $56M in funding for endovascular tech

Funds a pivotal trial of a next-gen aspiration catheter for large-vessel stroke thrombectomy, which may improve clot retrieval when current devices fail.

Neurology · Fierce Biotech · 22 Sept

Alzheimer’s cases in India could be up to 5 times higher than reported number: Experts

Dementia is likely far more common than clinic figures suggest, so screen cognitively in older patients rather than waiting for memory complaints.

Neurology · ETHealthworld · 21 Sept

Beyond the Hospital: Spatial Inequality and Structural Divergence in Stroke Mortality Across the United States (2020-2024)

Largest relative increases in medium (+8.4%) and large fringe metros (+7.3%); home deaths surged in 2021 (n=41,423); out-of-hospital Gini=0.5321 versus in-hospital Gini=0.5045.

Neurology · Cureus · 21 Sept

Cell-Type-Specific Transcriptomic Alterations in the Epileptic Prefrontal Cortex and Complementary Neuroimaging Findings in an Independent Cohort

Maps which prefrontal cell types are transcriptionally altered in epilepsy and links them to imaging changes, pointing toward cell-specific targets rather than seizure-focus-only models.

Neurology · Cureus · 21 Sept

Imaging Correlation of Color Doppler Ultrasound, CT Angiography, and MR Angiography Findings in Extracranial Carotid and Vertebral Artery Disease Among Ischemic Stroke Patients: A Prospective Observational Study

Doppler agrees well enough with CTA/MRA for first-line carotid and vertebral stenosis workup, so you can triage stroke patients without immediate advanced angiography.

Neurology · Cureus · 21 Sept

Basilar Artery Occlusion Associated With Paradoxical Embolism After Traumatic Spinal Cord Injury: A Case Report

CT angiography showed partial distal basilar occlusion; mechanical thrombectomy by direct aspiration achieved complete reperfusion (TICI 3). Echocardiography showed right-to-left shunting with more than 30 microbubbles from the second cardiac cycle.

Neurology · Cureus · 21 Sept

Endovascular Thrombectomy in Patients With Cancer and Acute Ischemic Stroke: A Systematic Review and Meta-Analysis

Recanalization 77.1%, sICH 4.5%, mRS ≤2 in 26.8%, 90-day death 39.4%. Versus controls: mRS ≤2 RD -0.170 (95% CI -0.223 to -0.116); mortality RD 0.234 (95% CI 0.168 to 0.300).

Neurology · Cureus · 21 Sept

Antiphospholipid Syndrome as an Under-Recognized Cause of Ischemic Stroke in Older Adults: A Retrospective Case Series

Consider testing antiphospholipid antibodies in stroke patients over 65, not just the young—seven cases here suggest it is missed in older adults.

Neurology · Cureus · 21 Sept

A Small Dose With Large Movements: Suspected Gabapentin-Associated Mixed Hyperkinetic Movement Disorder in End-Stage Renal Disease: A Case Report

Involuntary jerking and truncal sway appeared after roughly one month of gabapentin; movements and altered affect resolved within approximately 48 hours of discontinuation

Neurology · Cureus · 20 Sept

Ocrelizumab Discontinuation After Recurrent Serious Infections in Clinically Stable Primary Progressive Multiple Sclerosis: A Case Report

In stable PPMS patients on long-term ocrelizumab, recurrent serious infections may justify stopping therapy even without disease activity — weigh infection risk against relapse risk as patients age.

Neurology · Cureus · 20 Sept

Lower Motor Neuron Disease Misclassified As Inflammatory Myopathy in a Young Woman With Myositis-Specific Antibodies

Despite creatine kinase normalisation on immunosuppression, weakness and wasting progressed; re-evaluation showed widespread fasciculations, neurogenic atrophy, and a lower-motor-neuron-predominant ALS phenotype.

Neurology · Cureus · 20 Sept

When Weakness Persists Beyond Its Apparent Cause: A Case Report of Myasthenia Gravis

In a patient with diarrhea and hypokalemia, weakness that persists after potassium correction should prompt consideration of myasthenia gravis rather than being attributed to the electrolyte deficit alone.

Neurology · Cureus · 20 Sept

Efficacy of Medical Treatment Options for Reducing the Risk of Bleeding in Patients With Sporadic and Familial Cerebral Cavernous Malformations: A Systematic Review and Network Meta-Analysis

Statin vs no treatment: OR 0.32 (95% CI 0.14-0.73) for follow-up bleeding. Triple therapy vs none: OR 0.24 (0.06-0.95). Beta-blocker monotherapy vs antithrombotic: OR 2.41 (1.13-5.10).

Neurology · Cureus · 18 Sept