Archive

Diagnostic Performance of Platelet Volume Indices in Thrombocytopenia: A Single-Center Observational Study in Central India

MPV, PDW and plateletcrit from a routine CBC may help you separate hyperdestructive from hypoproductive thrombocytopenia before ordering marrow studies or immune workup.

General Medicine · Cureus · 10d

Nationwide Trends in Hospitalization, In-Hospital Case Fatality, and Hospital Reimbursement for Skin and Soft-Tissue Infections in Brazil, 2000-2023: An Ecological Time-Series Analysis

Shows how a high-volume, low-mortality admission like cellulitis behaves over decades — useful context when you weigh admission versus oral outpatient management.

General Medicine · Cureus · 10d

One in four tribal adults in Odisha has impaired kidney function: ICMR study

A quarter of 19,703 tribal adults screened had impaired kidney function, so consider eGFR testing in Adivasi patients from these 14 districts rather than waiting for symptoms.

General Medicine · ETHealthworld · 11d

Non-prescription Antibiotic Dispensing in Community Pharmacies of Islamabad Capital Territory, Pakistan: A Simulated Client Study

Simulated clients were readily sold antibiotics without prescriptions in Islamabad, so assume patients arrive already partially treated and counsel on completing prescribed courses.

General Medicine · Cureus · 11d

When a Contaminant Is Not a Contaminant: A Case Report of Micrococcus luteus Causing Septic Shock in the Absence of Traditional Risk Factors

Multiple blood cultures grew M. luteus, confirming true bacteremia rather than contamination; she required fluid resuscitation, vasopressors and intravenous antibiotics, then improved with clearance of bacteremia.

General Medicine · Cureus · 11d

Invasive Infection Associated With Probiotics in Adults: Does the Pathogen Originate From the Product or the Host Intestine?

Before prescribing probiotics to ICU or immunocompromised patients, note that strain-level typing is needed to tell product-derived bacteremia from the patient's own flora.

General Medicine · Cureus · 11d

Pulmonary Embolism With Pulmonary Infarction Despite Low-Risk Prediction Scores: Atypical Pleuritic, Abdominal, and Shoulder Pain

PERC, Wells and Geneva scores all indicated low pretest probability despite CT angiography confirming subsegmental PE with pulmonary infarction; D-dimer was near-threshold

General Medicine · Cureus · 11d

Comparative Clinical Outcomes of Fractional CO₂ Laser-Assisted Topical Therapy for Nail Psoriasis: A Systematic Review

Direct comparative effects were inconsistent across studies and varied by topical agent, comparator and assessment time. Advantages appeared in selected tazarotene and methotrexate comparisons; other comparisons showed no clear incremental benefit. Meta-analysis was not possible due to heterogeneity.

General Medicine · Cureus · 12d

Visceral Leishmaniasis Presenting as Hemophagocytic Lymphohistiocytosis in a Non-endemic Setting: A Case Report

HLH features prompted anakinra and corticosteroids; VL was then confirmed by serology, PCR and histopathology, and liposomal amphotericin B produced rapid clinical improvement

General Medicine · Cureus · 12d

Efficacy and safety of mitapivat in patients with sickle cell disease (RISE UP): a phase 3, double-blind, global, randomised, placebo-controlled trial.

An oral pyruvate kinase activator that raises haemoglobin and cuts haemolysis could give sickle cell patients a disease-modifying pill instead of transfusions and hydroxyurea alone.

General Medicine · Lancet · 12d

Intramuscular Vitamin D2 in Patients With Systemic Sclerosis Not Responding to Oral Supplementation: A Retrospective Observational Case Series

If your scleroderma patient stays below 30 ng/mL on oral cholecalciferol, gut malabsorption may be the cause; IM ergocalciferol is a practical alternative worth trying.

General Medicine · Cureus · 13d

Efficacy and Safety of Revefenacin Versus Glycopyrronium in Indian Chronic Obstructive Pulmonary Disease (COPD) Patients: A Randomized, Active-Controlled, Phase III Trial

A once-daily nebulized LAMA now has Indian efficacy and safety data, giving an option for COPD patients who cannot use handheld inhalers reliably.

General Medicine · Cureus · 13d

Centre flags data gap, regulatory hurdles in curbing hospital mark-ups

Consumable mark-ups of 100-1,000% hit your patients' bills directly, but no national margin data exists yet to justify price caps you may be asked about.

General Medicine · ETHealthworld · 13d

Microsoft develops AI tool that can diagnose 'sequentially' like a doctor

A simulated panel of specialists that sequences history, tests and orders could change how undifferentiated cases are worked up — but it is unvalidated in real clinics.

General Medicine · ETHealthworld · 13d

Ravulizumab in IgA Nephropathy - Interim Analysis of a Phase 3 Trial.

Terminal complement blockade may slow proteinuria and nephron loss in IgA nephropathy, offering a targeted alternative to renin-angiotensin blockade alone.

General Medicine · NEJM · 13d

FibriLysins disrupt Staphylococcus aureus biofilms and abscess communities.

If engineered staphylokinase-endolysin enzymes clear fibrin-encased MRSA abscesses in vivo, this offers a non-antibiotic adjunct for the recurrent skin and soft-tissue infections you already struggle to cure.

General Medicine · Nature microbiology · 13d

Interim Analysis of a Phase 3 Trial of Povetacicept in IgA Nephropathy.

Dual BAFF/APRIL blockade targets the B-cell drivers of IgA nephropathy; if proteinuria falls durably, it becomes a disease-modifying option beyond renin-angiotensin blockade.

General Medicine · NEJM · 13d

Diagnostic Tools Used for Tuberculous Pleural Effusion and Their Association With Treatment Outcomes

In paucibacillary TPE, your choice of pleural fluid biomarker, molecular assay or biopsy — not just availability — tracks with treatment outcome, so escalate diagnostics early.

General Medicine · Cureus · 14d

Sentara Health deploys new AI case management tool co-developed with Regard

An AI tool claiming 90,000 staff hours saved in acute care signals where hospital case management is heading — worth watching if your ward's discharge and follow-up load is the bottleneck.

General Medicine · Fierce Healthcare · 14d

STAT+: FDA has finalized its guidance on apps related to drugs

If you prescribe apps or device-linked software with a drug, the FDA's final rule now fixes who regulates it and what claims you can rely on.

General Medicine · STAT News — Health Tech · 14d

Declining Leprosy-Related Hospitalization Rates and Increasing In-Hospital Case Fatality in Brazil: A Nationwide Ecological Time-Series Study, 2008-2023

Fewer leprosy admissions but higher in-hospital death signals delayed presentation; watch for late-stage disease in your own referrals.

General Medicine · Cureus · 14d

TN conducting India's first dengue vaccine pilot study, says Minister Arunraj

If the Brazilian-schedule vaccine proves feasible here, dengue hospitalisations in your paediatric and adult practice could fall; watch for pilot safety data before advising families.

General Medicine · ETHealthworld · 14d

Stricter diagnostic lab rules for CGHS fuel double standards charge

If you refer CGHS patients, tighter lab categorisation may change which tests are covered where, so check empanelment before sending samples.

General Medicine · ETHealthworld · 14d

Case Mix and Protocol Constraints in Diagnostic Language Model Conversations: A Secondary Analysis of Released MedR-Bench Outputs

Benchmark scores for diagnostic AI partly reflect the test protocol and simulator, not clinical reasoning — so don't read a leaderboard as readiness for your ward.

General Medicine · Cureus · 14d

CureBay Bags ₹100 Cr To Scale Rural Clinics Network, Enhance AI Screening Offerings

If you refer patients in underserved districts, this funds more rural clinics with AI-assisted screening — worth knowing where your patients can get checked closer to home.

General Medicine · Inc42 · 14d

Sibeprenlimab in IgA Nephropathy - Final Phase 3 Trial Analysis.

Final phase 3 data on APRIL inhibition give nephrologists a clearer picture of proteinuria and eGFR benefit before deciding where sibeprenlimab fits alongside standard IgA nephropathy care.

General Medicine · NEJM · 14d

Rituximab vs Azathioprine for Eosinophilic Granulomatosis With Polyangiitis Maintenance Therapy: A Randomized Clinical Trial.

Direct head-to-head data on which maintenance agent keeps EGPA patients in remission longer, where guidelines currently offer only weak recommendations.

General Medicine · JAMA · 14d

Atacicept in IgA Nephropathy - Phase 3 Trial Final Efficacy Analysis.

Final ORIGIN 3 results confirm atacicept's proteinuria reduction in biopsy-proven IgA nephropathy, giving nephrology a targeted option beyond supportive care for patients at risk of progression.

General Medicine · NEJM · 14d

BCG at 100: The Paradox of an Indispensable Vaccine.

Reinforces that BCG at birth protects infants from disseminated TB but not adult pulmonary disease, so adolescent and adult TB control still depends on case-finding and treatment.

General Medicine · Indian pediatrics · 14d

Ianalumab for the Treatment of Patients with Sjögren's Disease.

Sjögren's has no approved targeted therapy; a B-cell depleting BAFF-receptor antibody could finally give you a disease-modifying option beyond symptomatic care.

General Medicine · NEJM · 14d

Doximity adds UpToDate to Ask in push to become doctors’ go-to AI platform

If your hospital or app stack uses Doximity Ask, answers will now be grounded in UpToDate content rather than generic model output — worth knowing before you trust it at the bedside.

General Medicine · Fierce Healthcare · 21 Oct

Persistent Sleepiness After Effective Positive Airway Pressure Therapy Deserves Independent Clinical Evaluation

When a patient on PAP still reports daytime sleepiness despite good adherence and control, work it up separately rather than escalating pressure or dismissing it as treated OSA.

General Medicine · Cureus · 21 Oct

HHS launches national kidney care plan focused on disease prevention, dialysis care and reforming the transplant system

A US policy blueprint, not Indian guidance — but its prevention-first framing and transplant reform signal where nephrology capacity debates are heading.

General Medicine · Fierce Healthcare · 21 Oct

Baba nabs $40M series A, backed by FirstMark Capital and CVS Health Ventures, for AI-powered Medicare patient navigation

If your Medicare patients get AI navigation support through their plan, expect fewer missed referrals and more care-coordination queries landing in your clinic.

General Medicine · Fierce Healthcare · 21 Oct

A Case of Legionella Disease Mimicking Dermatomyositis

Legionella can present with rash and myalgia that mimic dermatomyositis, so consider it in severe pneumonia with skin findings before starting steroids.

General Medicine · Cureus · 21 Oct

Evaluation of Catheter-Associated Urinary Tract Infection Rates in Surgical and Medical Intensive Care Units at a Tertiary Care Center: A Surveillance Study From North India

Local CAUTI rates give you a benchmark to audit your own ICU catheter days and justify early removal protocols.

General Medicine · Cureus · 21 Oct

A Case Report of Lichen Amyloidosis

Lichen amyloidosis mimics common chronic dermatoses; keep it in the differential for persistent pruritic papules so diagnosis isn't delayed by years of eczema treatment.

General Medicine · Cureus · 21 Oct

Strategic Optimization of Nurse-Patient Ratios Across Units and Shifts in a Teaching Hospital

Fixed ward-wide staffing ratios ignore shift and acuity swings; unit- and shift-specific ratios may cut the understaffed shifts where your patients come to harm.

General Medicine · Cureus · 21 Oct

Inequality is major factor in impact of non-communicable diseases: WHO

Your NCD patients' outcomes depend as much on their income and locality as on the drug you prescribe, so screening and follow-up need to target the most disadvantaged groups.

General Medicine · ETHealthworld · 21 Oct

Anticoagulation Monitoring in Recurrent Venous Thromboembolism Associated With Antiphospholipid Antibodies and Subsequent Heparin-Induced Thrombocytopenia

In triple-positive antiphospholipid patients, baseline aPTT and INR are uninterpretable — a prolonged aPTT before any heparin can mask or mimic HIT, so use paired samples and functional assays.

General Medicine · Cureus · 21 Oct