Archive

Patient-Reported Outcomes After Septoplasty With Bilateral Radiofrequency Inferior Turbinate Reduction: A Prospective Cohort Study

Confirms combined septoplasty and radiofrequency turbinate reduction improves patient-reported nasal obstruction and quality of life, supporting the combined procedure in symptomatic septal deviation with turbinate hypertrophy.

General Surgery · Cureus · 18 Sept

CMS restores $12B in frozen supplemental Medicaid funds

Restored payments to safety-net hospitals protect staffing and services that many of your Medicaid patients depend on.

Medicine · Fierce Healthcare · 18 Sept

Post-acne Erythema: A Systematic Review of Randomized Controlled Trials on the Comparative Efficacy and Safety of Interventions Across Clinical, Instrumental, and Patient-Reported Outcomes

No intervention has proven standard for post-acne erythema; this review maps which randomized options actually reduce redness so you can counsel patients realistically.

General Medicine · Cureus · 18 Sept

Unmasking Brugada Syndrome With Oral Propafenone in a Resource-Limited Setting: A Case Report

Oral propafenone can unmask type 1 Brugada patterns where IV ajmaline or flecainide is unavailable, letting you confirm the diagnosis before a fatal arrhythmia does.

Cardiology · Cureus · 18 Sept

Postextubation Stridor: An Analysis of Incidence, Risk Factors, and Clinical Outcomes in Mechanically Ventilated Patients

22 of 651 (3.4%) developed PES; 36.4% (8/22) were reintubated; 30-day and 60-day mortality were both 0%. Female sex was independently associated (OR 3.65; 95% CI 1.49-9.47).

Anaesthesiology · Cureus · 18 Sept

Assessment of Preoperative Serum Vitamin D Levels in Differentiated Thyroid Cancer

If low preoperative vitamin D tracks with differentiated thyroid cancer, it is a cheap, already-ordered test that could flag patients needing closer thyroid evaluation.

Oncology · Cureus · 18 Sept

Artelo’s ex-AstraZeneca cannabinoid agonist holds its own against GLP-1 drug semaglutide in obese mice

A preclinical oral cannabinoid agonist matched semaglutide for weight loss in mice, but human data are years away and clinicians should not expect a near-term alternative.

Endocrinology · Fierce Biotech · 18 Sept

FSSAI takes legal action against Nestle India over sub-standard infant formula

Two Nestle infant formulas face regulatory action over HMO and whey protein claims, so verify what you tell parents about these products' composition.

Paediatrics · ETHealthworld · 18 Sept

Pulsed Low-Dose-Rate Radiotherapy (PLDR): A Comprehensive Review of Radiobiological Rationale and Clinical Applications in Modern Cancer Care

PLDR lets you re-irradiate previously treated fields with less normal-tissue toxicity, useful when reirradiation is the only local option left.

Oncology · Cureus · 18 Sept

Impact of Short-Term Fluoride Supplementation in Pregnancy on the Maternal Microbiome, Pregnancy, and Neonatal Outcomes: A Pilot Randomized Controlled Trial

No differences in vaginal microbiome richness or diversity between groups. Oral taxa differences were nominal and unadjusted for multiple testing. Clinical outcomes showed no consistent pattern; the trial was not powered for efficacy or safety.

Obstetrics & Gynaecology · Cureus · 18 Sept

Clinical and Patient-Reported Outcomes in Non-English-Speaking Patients Undergoing Primary Total Knee Arthroplasty

Language barriers may worsen short-term TKA outcomes independent of ethnicity, so arrange interpreters and translated rehab instructions for non-English-speaking patients.

Orthopaedics · Cureus · 18 Sept

Does That Thumb Trigger Finger Release Have You Feeling “Nerve”-ous?

Radial and ulnar digital nerves cross the thumb flexion crease at variable positions, so blind percutaneous release risks transection; know the anatomy before cutting.

Orthopaedics · Cureus · 18 Sept

Intrabiliary Rupture of a Hepatic Hydatid Cyst Causing Mechanical Biliary Obstruction: A Case Report of Endoscopic Management With a Self-Expandable Metal Stent

In endemic hydatid regions, endoscopic SEMS placement can decompress cyst-related biliary obstruction without surgery, though stent-related cholangitis and long-term patency need follow-up.

Gastroenterology · Cureus · 18 Sept

Salvage Management of Anterior-Posterior Compression (APC) Type II Pelvic Ring Injury Using Isolated Posterior Fixation After Anterior Implant Removal: A Case Report

When anterior pelvic implants fail or infect, isolated posterior fixation can still salvage an APC-II ring, sparing your patient a redo anterior approach.

Orthopaedics · Cureus · 18 Sept

With pioneering ADHD data, Alkermes eyes orexin agonist as potential ‘company changer’

If orexin agonists work in ADHD, a new non-stimulant mechanism may eventually reach patients who cannot tolerate or misuse current stimulants.

Psychiatry · Fierce Biotech · 18 Sept

Discordance Between Gated Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging and Coronary Angiography in Dilated Cardiomyopathy

In DCM, SPECT-MPI and angiography can disagree on ischaemic versus non-ischaemic aetiology, so don't let a perfusion report alone decide whether a patient needs revascularisation workup.

Cardiology · Cureus · 18 Sept

DPHARM: Where to begin with AI in clinical trials?

AI is entering trial recruitment and monitoring first, so expect AI-screened referrals and algorithm-flagged safety signals in studies your patients join.

Medicine · Fierce Biotech · 18 Sept

Assessing the Influence of Propofol Sedation Versus Propofol-Free Sedation on Recovery From Sepsis and Septic Shock in Mechanically Ventilated ICU Patients: A Retrospective, Propensity-Score Matched, Cohort Study

Median ICU-free days were similar: 6.3 (2.1-14.7) non-propofol versus 6.8 (3.3-13.3) propofol, p=0.303. Before matching, mortality was higher without propofol (43.3% vs 32.3%, p=0.031); after matching, no significant difference.

Anaesthesiology · Cureus · 18 Sept

Clotting Beyond Boundaries: Extensive Iliocaval Thrombosis Revealing Homozygous Factor V Leiden Mutation in a Young Adult Following Prolonged Air Travel

In a young patient with extensive thrombosis after long-haul travel, test for inherited thrombophilia such as homozygous factor V Leiden, not just provoked VTE.

General Medicine · Cureus · 18 Sept

Refreshed Novo corrals 3 new early-stage obesity drugs from Kallyope

Three early-stage obesity candidates entering Novo's pipeline signal more oral or combination options may reach your patients within a few years.

Endocrinology · Fierce Biotech · 18 Sept

Op-ed: Health AI is moving fast. America needs rules that keep up

A patchwork of US state AI rules could delay the clinical tools you will soon be asked to trust; watch for a single national standard instead.

Medicine · Fierce Healthcare · 18 Sept

Medtronic earns FDA clearance for LigaSure use with its Hugo robotic system

Adds a robotic vessel-sealing option to a system already used in India, widening instrument choice for minimally invasive surgery.

General Surgery · Fierce Biotech · 18 Sept

Incidence and Progression of Acute Kidney Injury Following Head and Neck Surgeries for COVID-19-Associated Mucormycosis: A Prospective Observational Study

AKI developed in 9 of 49 patients (18.4%). Pre-existing hypertension was more prevalent in AKI patients (77.8% vs 32.5%; p = 0.02), and baseline eGFR was lower (87.4 ± 27.1 vs 102.9 ± 17.4 mL/min/1.73 m²; p = 0.03).

Anaesthesiology · Cureus · 18 Sept

FDA clears Aptitude’s latest Metrix molecular dx to test for COVID

A faster, more sensitive COVID test could improve turnaround and detection in acute respiratory presentations, though Indian labs will need to validate availability and cost.

General Medicine · Fierce Biotech · 18 Sept

STAT+: A geriatrician explains why AI for older adults deserves careful scrutiny

Before trusting AI triage or risk scores in elderly patients, know that frailty, atypical presentation and multimorbidity can make model outputs misleading.

General Medicine · STAT News — Health Tech · 18 Sept

Underestimation of Low-Density Lipoprotein Cholesterol (LDL-C) Using the Friedewald Equation at Higher Triglyceride Levels: Evidence From a Method-Comparison Study

Mean bias rose to +20.2 mg/dL (-17.0 to 57.5) at TG 250-300 and +26.5 mg/dL (-17.7 to 70.6) above 300 mg/dL; 58.7% and 58.1% respectively were assigned to a lower LDL-C band.

Cardiology · Cureus · 18 Sept

Xenon pauses phase 3 depression trials after psychosis events

A novel antidepressant mechanism has now produced psychosis signals in phase 3, so weigh this risk before recommending any new non-monoaminergic agent to your patients.

Psychiatry · Fierce Biotech · 18 Sept

Efficacy of Medical Treatment Options for Reducing the Risk of Bleeding in Patients With Sporadic and Familial Cerebral Cavernous Malformations: A Systematic Review and Network Meta-Analysis

Statin vs no treatment: OR 0.32 (95% CI 0.14-0.73) for follow-up bleeding. Triple therapy vs none: OR 0.24 (0.06-0.95). Beta-blocker monotherapy vs antithrombotic: OR 2.41 (1.13-5.10).

Neurology · Cureus · 18 Sept

Procalcitonin-Guided Antimicrobial Therapy: Current Evidence for Clinical Decision-Making and Practical Limitations

PCT-guided therapy reduces antibiotic exposure without worsening major clinical outcomes when used to guide discontinuation; its role in guiding antibiotic initiation remains limited, particularly in sepsis.

General Medicine · Cureus · 18 Sept

BMS dumps $100M Orum degrader-antibody conjugate after glimpsing phase 1 data

A novel degrader-antibody conjugate failed early phase 1, a reminder that promising preclinical oncology platforms often do not translate into tolerable human activity.

Oncology · Fierce Biotech · 18 Sept

Beyond the Bowel: A Narrative Review Examining Bidirectional Mental Health Pathways Across Disorders of Gut-Brain Interaction and Inflammatory Bowel Disease

No primary numerical result reported. Longitudinal links between GI illness and psychiatric outcomes do not establish individual causation; many symptom-generating mechanisms rest mainly on preclinical evidence.

Gastroenterology · Cureus · 18 Sept

Iodine nutrition, thyroid function, and thyroid autoimmunity four decades after Universal Salt Iodisation in India: a cross-sectional study among schoolchildren (ICMR-SALT-T 1).

Four decades of salt iodisation may now be causing iodine excess and rising thyroid autoimmunity in Indian children, so consider this before attributing paediatric thyroid dysfunction to deficiency.

Endocrinology · Lancet regional health. Southeast Asia · 18 Sept

Epidemiology of Kyasanur forest disease in India, 2000-2025: a systematic review and meta-analysis.

KFD has spread beyond Karnataka; know the pooled positivity and case-fatality so you suspect it in febrile patients with tick exposure in new districts.

General Medicine · Lancet regional health. Southeast Asia · 18 Sept

Precision prevention and early detection: framework for a new clinical cancer control pathway.

Only 13% of cancers are found by screening and up to half present via emergency, so risk-stratified prevention and detection pathways could shift your patients to earlier-stage diagnosis.

Oncology · Lancet · 18 Sept

Empirical Antibiotic Therapy for the Management of Empyema Thoracis in Children: A Systematic Review.

Cloxacillin was empirical therapy in 10/17 studies (638 children), appropriate in six (419 children) as Staphylococcus aureus dominated. Third-generation cephalosporins used in 9/17 studies (444 children), appropriate in four (283 children).

Paediatrics · Indian pediatrics · 18 Sept

Survival benefit of deceased donor kidney transplantation versus continued dialysis: international target trial emulation.

Among 75 year olds, expanded criteria donor/donation after circulatory death five year survival was 59% (51% to 66%) versus 55% (54% to 55%) on dialysis; hazard ratio 0.97 (0.70 to 1.33).

Urology · BMJ · 18 Sept

A universal visual foundation model for computational cytopathology.

CROWN achieved best overall performance among established pretrained encoders; accuracy exceeded 95% in 48 patch-level classification evaluations and 98% in 22 of them.

Oncology · Nature cancer · 18 Sept

Time to diagnosis of acute kidney injury and its predictors among outborn neonates in India: a competing-risk analysis of tele-ICU network data (2022-2024).

AKI occurred in 170 (29.8%); median time to diagnosis 2 days (IQR 1-5); five-day cumulative incidence 0.23 (95% CI 0.20-0.27). Dehydration, ventilation and vasopressors predicted early AKI.

Paediatrics · Lancet regional health. Southeast Asia · 18 Sept

Massive Early Post-Tracheostomy Hemorrhage From Inferior Thyroid Artery Branch Injury: An Oxygenation-Preserving Airway Rescue Strategy

Bleeding arose from inferior thyroid artery branches and required ligation and tracheostomy revision; oxygenation was maintained by digital compression while ventilating through the existing tracheostomy tube during video-laryngoscopic intubation.

Anaesthesiology · Cureus · 18 Sept

Postvoid Residual Urine as a Clue to the Diagnosis of Acute Bacterial Prostatitis: A Case Report

In a febrile man without perineal pain or prostatic tenderness, a raised postvoid residual may be the only pointer to acute bacterial prostatitis.

Urology · Cureus · 18 Sept