Archive

Sertoli-Leydig Cell Tumour With Heterologous Elements Presenting as Hyperandrogenaemia and Markedly Elevated Alpha-Fetoprotein: A Challenging Diagnosis

Young women with presumed PCOS and progressive virilisation need androgen and AFP testing, since a rare ovarian Sertoli-Leydig tumour can mimic PCOS for years.

Obstetrics & Gynaecology · Cureus · 24 Sept

Effectiveness of Antenatal Interventions in Preventing Pregnancy-Related Complications: A Systematic Review

Structured antenatal lifestyle and dietary interventions reduce gestational diabetes and preeclampsia risk, so prioritise them in routine ANC counselling rather than treating these outcomes as unavoidable.

Obstetrics & Gynaecology · Cureus · 24 Sept

Not All Brain Bleeds Are Equal: An Etiology-First Framework for Stroke Prevention After Intracerebral Hemorrhage

Before restarting a DOAC after ICH, weigh the bleed's cause: lobar amyloid bleeds recur more than deep hypertensive ones, so the anticoagulation decision should differ.

Neurology · Cureus · 24 Sept

Multi-method Machine-Learning Identification of IL11 as a Key Gene in Kidney Stone Disease: Mechanistic Clues and Diagnostic Potential

IL11 was significantly upregulated in Randall's plaque (Wilcoxon P=8.9×10⁻⁵). Single-gene diagnostic model: apparent AUC 0.782 (95% CI 0.663-0.901), out-of-bag AUC 0.756.

Urology · Cureus · 24 Sept

Clinical Performance and Safety of the Optima Non-compliant Percutaneous Transluminal Coronary Angioplasty Balloon in Contemporary Percutaneous Coronary Intervention: A Multicenter Real-World Study

Real-world multicentre data on a high-pressure NC balloon give you procedural success and short-term safety figures to weigh when choosing lesion preparation and stent optimisation devices.

Cardiology · Cureus · 24 Sept

Psychosocial Rehabilitation Interventions for Mental Health Disorders: A Systematic Review

Cognitive remediation, CBT-integrated programs, Housing First, peer-led rehabilitation and digital self-management showed potential benefits for negative symptoms, social functioning, housing stability, recovery and service utilization

Psychiatry · Cureus · 24 Sept

How to combat the insurer payment delays that are destabilizing independent medicine

Persistent No Surprises Act payment delays strain independent practice cash flow, so know the IDR timelines and documentation you can use to chase unpaid claims.

General Medicine · Fierce Healthcare · 24 Sept

Rifaximin Versus Placebo for Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Global symptom relief improved with rifaximin (RR 1.54, 95% CI 1.13 to 2.11; p=0.014; NNTB 6), but heterogeneity was substantial (I2=59.5%) and the 95% prediction interval crossed no effect (0.89-2.67).

Gastroenterology · Cureus · 24 Sept

Acadia misses mark in Alzheimer’s but concludes phase 3 ‘absolutely worth’ pursuing

A negative phase 2 in Alzheimer's still advancing to phase 3 signals the endpoint may be wrong, not the drug — wait for phase 3 before discussing this with patients.

Neurology · Fierce Biotech · 24 Sept

Complete Response to First-Line Trastuzumab Deruxtecan in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Extra-axial Central Nervous System Metastases

Suggests T-DXd can be used first-line for HER2-positive extra-axial CNS metastases, where treatment options are limited and prognosis poor.

Oncology · Cureus · 24 Sept

Breaking the Storm: Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome as the First Manifestation of Systemic Lupus Erythematosus/Mixed Connective Tissue Disease in an Adolescent Successfully Treated With Anakinra

In a febrile adolescent not responding to antibiotics, consider MAS as the first sign of SLE; anakinra can achieve rapid remission.

Paediatrics · Cureus · 24 Sept

First Presentation With Impending Cardiac Tamponade Leading to a New Diagnosis of Mediastinal Lymphoma: A Shared Learning Case on the Atypical Presentation of Pericardial Effusion and Cardiac Tamponade

A young woman with dyspnoea and oedema but no full Beck's triad had tamponade from undiagnosed mediastinal lymphoma; keep effusion on the differential when the classic signs are absent.

Cardiology · Cureus · 24 Sept

STAT+: In radiology, AI is blurring the line between technology development and clinical practice

Practices building their own AI tools may soon compete for your imaging referrals, so know what 'AI-native' radiology claims actually deliver.

Radiology · STAT News — Health Tech · 24 Sept

Merck sees pivotal victory for $3B eye disease prospect

A trispecific intravitreal agent met its primary endpoint in DME, potentially adding a longer-acting option to anti-VEGF therapy if approved.

Ophthalmology · Fierce Biotech · 24 Sept

Multifocal Inflammatory Pseudotumor Involving the Orbit, Skull Base, and Cauda Equina Causing Progressive Visual Loss in a Patient With HIV Infection: A Case Report

In an HIV patient with progressive visual loss, consider inflammatory pseudotumor involving orbit and skull base, not just infection or lymphoma; biopsy guides steroid-sparing management.

Ophthalmology · Cureus · 24 Sept

Prospective Clinical Evidence on Artificial Intelligence-Enabled Augmented and Mixed Reality in Robot-Assisted Prostate and Kidney Cancer Surgery: A Systematic Review

Evidence for AI-guided augmented reality in robotic prostatectomy and partial nephrectomy is still sparse and heterogeneous, so treat these overlays as promising but unproven in your OR.

Urology · Cureus · 24 Sept

Aquatic Interventions for Children and Adolescents With Autism Spectrum Disorder: A Systematic Review and Meta-Analysis of Motor, Sleep, Executive Function, and Adaptive Measures

Pooled estimates favored aquatic intervention for sleep (g = 1.76, 95% CI 1.16 to 2.37), motor and balance (g = 1.49, 95% CI 0.91 to 2.07), and executive function (g = 0.92, 95% CI 0.35 to 1.46); social and adaptive outcomes were not significant (g = 0.38, 95% CI −0.17 to 0.94).

Paediatrics · Cureus · 24 Sept

Short Implants Versus Sinus Floor Elevation With Standard Implants in the Atrophic Posterior Maxilla: A Systematic Review and Meta-Analysis

Short implants may avoid sinus lift surgery in atrophic posterior maxilla, sparing patients a second surgical site if survival and bone loss prove comparable.

Orthopaedics · Cureus · 24 Sept

Tuberculosis of the Sphenoid Sinus Causing Blindness in a Pediatric Patient: A Case Report

In a TB-endemic setting, consider sphenoid sinus TB in a child with vision loss and sinus opacities, since it mimics malignancy and delays cost vision.

Paediatrics · Cureus · 24 Sept

Cloud-Based AutoML Classification of Malignant and Non-malignant Colorectal Findings on Abdominal Computed Tomography: A Proof-of-Concept Study

At a 0.50 confidence threshold, average precision was 0.998, with precision and recall approximately 99%; 97% of malignant and 100% of non-malignant images were correctly classified.

Radiology · Cureus · 24 Sept

FSSAI proposes single-phase food warning labels, gives industry one-year transition time

Red hexagon labels on high sugar, fat and salt foods give you a concrete counselling tool for diet-related diabetes, obesity and hypertension in Indian patients.

General Medicine · ETHealthworld · 24 Sept

Grail survives adcomm vote as it awaits FDA decision for cancer blood test

A positive FDA panel vote moves Galleri closer to approval as a multi-cancer screening blood test, though its earlier trial miss means sensitivity limits still matter for how you counsel patients.

Oncology · Fierce Biotech · 24 Sept

Fumarate Hydratase-Deficient Renal Cell Carcinoma in a Solitary Kidney: Diagnostic Pitfalls and Onco-Nephrology Constraints in an Older Adult With Chronic Kidney Disease

FH-deficient RCC mimics papillary RCC; in a solitary kidney with CKD, misclassification can lead to nephrectomy when nephron-sparing options matter.

Urology · Cureus · 24 Sept

Faecal microbiota transplantation in irritable bowel syndrome (REFIT2): a randomised, double-blind, placebo-controlled, phase 3 trial.

Phase 3 data on FMT for IBS will tell you whether to offer it to refractory patients or keep managing them with diet, antispasmodics and neuromodulators.

Gastroenterology · Lancet · 24 Sept

Optimizing the delivery of radiotherapy with artificial intelligence.

AI already automates contouring, planning and QA in radiotherapy; knowing where it is validated tells you which tasks you can safely delegate.

Oncology · Nature reviews. Clinical oncology · 24 Sept

Evorpacept plus trastuzumab, ramucirumab and paclitaxel in HER2-positive gastric cancer: a randomized phase 2 trial.

Adds a CD47-blocker to standard second-line HER2 therapy in pretreated gastric cancer; check the response data before considering it for your patients.

Oncology · Nature Medicine · 24 Sept

Gut microbiome shifts in chronic systolic heart failure are associated with disease severity and clinical improvement.

Microbiome composition tracked HF severity and clinical improvement, hinting at gut-derived targets or markers, but this is early mechanistic work with no therapy ready for patients.

Cardiology · Nature cardiovascular research · 24 Sept

Phase 1 Study of Anito-cel, a d-Domain BCMA CAR T Cell for Refractory or Recurrent Myeloma.

Of 38 treated, all 38 (100%) responded and 79% had complete response. At median follow-up 38.1 months, 24-month PFS was 57%, median PFS 30.2 months, 36-month OS 65%.

Oncology · NEJM · 24 Sept

Etuvetidigene Autotemcel for the Treatment of Wiskott-Aldrich Syndrome.

Severe infections fell from 2.00 to 0.15 per person-year (95% CI, 0.04 to 0.39); moderate or severe bleeding fell from 2.00 to 0.80 per person-year (95% CI, 0.49 to 1.22). Overall survival at 1 and 5 years was 96%.

Paediatrics · NEJM · 24 Sept

Clinical Uses of Common Genetic Variants Associated with Common Diseases.

Thousands of small-effect variants underpin polygenic risk; scores predict risk, yet have had little effect in the clinic. No effect sizes reported.

General Medicine · NEJM · 24 Sept

Pseudomonas aeruginosa induces the generation of pathogenic IFNγ(+)Th17 cells that promote lung damage and chronic inflammation in cystic fibrosis.

Two pathogenic Th17 subsets, Th1/17+ and pTh17, were selectively enriched in CF lungs colonised by P. aeruginosa, derived from cTh17 precursors, and disrupted epithelial integrity.

General Medicine · Nature microbiology · 24 Sept

Transient Gestational Hypertension and Its Subsequent Maternal and Perinatal Outcomes

Women whose blood pressure normalises during admission may still carry raised risks, so prolonged surveillance rather than early discharge could change how you counsel and follow them.

Obstetrics & Gynaecology · Cureus · 24 Sept

Standardising Pleural Management in Suspected Malignant Pleural Effusion Using a Structured Pre-Test Probability and RED Score-Guided Proforma: A Single-Centre Before-and-After Quality Improvement Project

Unplanned admission or early review fell from 16/48 (33.3%) to 2/26 (7.7%); risk difference −25.6% (95% CI −42.5 to −8.8), P=0.021. Procedures beyond two: 33.3% to 22.7%, not significant.

General Medicine · Cureus · 24 Sept

Prevalence and Trends of Post–COVID-19 Sequelae Among U.S. Adults With Prior COVID-19 Infection, 2022–2024

PASC prevalence declined from 19.7% in 2022 to 15.1% in 2023 and 13.7% in 2024 (P<0.001 for 2022 vs subsequent years); 6,822 of 42,872 reported PASC. Higher in women and adults aged 35-64.

General Medicine · Cureus · 24 Sept

Oracle Health rolls out AI solutions for RCM, oncology as part of broader healthcare, life sciences strategy

If your hospital runs Oracle Cerner, expect AI-driven coding and oncology workflow tools to reach your EHR; ask how they handle clinical validation and billing accuracy.

Oncology · Fierce Healthcare · 24 Sept

Clinical Presentation of, Treatment Approaches for, and the Impact of Social Determinants of Health on Pediatric Catatonia: A Structured Qualitative Synthesis and Targeted Literature Review

Pediatric catatonia is underrecognised; this synthesis flags lorazepam/ECT response and how social factors delay diagnosis, so you consider it earlier in withdrawn or mute children.

Psychiatry · Cureus · 24 Sept

Update on the Management of Acute Sigmoid Volvulus: Endoscopic Decompression and Definitive Surgical Treatment

Endoscopic detorsion relieves the acute episode but recurrence is common, so plan elective sigmoidectomy in fit patients rather than repeated decompressions.

General Surgery · Cureus · 23 Sept

Clinical and Echocardiographic Characterization of Stage B Heart Failure in Asymptomatic Adults With Cardiovascular Risk Factors

Nearly all asymptomatic at-risk adults had echo abnormalities, so screening echocardiography in patients with hypertension or diabetes may catch pre-HF before symptoms.

Cardiology · Cureus · 23 Sept

Kyverna ‘resetting conversation’ with 1-year miv-cel data as autoimmune CAR-T peers hit safety snags

One-year miv-cel data show durable autoimmune disease control without the safety signals now troubling rival CAR-T programmes, informing referral discussions for refractory patients.

Medicine · Fierce Biotech · 23 Sept

August AI, operating global chatbot in stealth mode, rolls out U.S. telehealth services

A free AI chatbot used by millions now adds US telehealth, signalling where patients may increasingly take first-contact symptoms before reaching you.

General Medicine · Fierce Healthcare · 23 Sept