Archive

Ticagrelor-Induced Bradyarrhythmias in Acute Coronary Syndrome: A Case Series of Three Patients

All three developed high-grade AV block, asystole or cardiac arrest after ticagrelor; two recovered after switching to prasugrel, one needed a permanent pacemaker. Naranjo rated the association possible in each.

Cardiology · Cureus · 25 Sept

Why Seizures Break Through: Distinguishing Background Susceptibility From Proximal Precipitants in Patients With Epilepsy

Distinguishing a patient's baseline seizure susceptibility from an immediate trigger like missed doses or sleep loss changes whether you reassure, adjust ASM, or investigate.

Neurology · Cureus · 25 Sept

Perioperative Safety Considerations and Surgical Outcomes Associated With GLP-1-Based Therapies: A Systematic Review

Observational studies showed increased residual gastric contents or delayed gastric emptying with GLP-1 RAs, especially semaglutide, despite standard fasting; clinically apparent aspiration or regurgitation was uncommon and mainly in case reports.

Anaesthesiology · Cureus · 25 Sept

Medical devices PLI scheme drives local output of MRI, CT scanners, heart valves: Centre

Domestically made MRI, CT and heart valves should mean cheaper, faster procurement and servicing for your hospital, though clinical equivalence data is not yet presented.

Medicine · ETHealthworld · 25 Sept

Robotic vs. Laparoscopic Stapling in Robotic Total Mesorectal Excision: A Prospective Cohort Study

Robotic stapling may cut the number of firings needed in rectal transection, potentially lowering anastomotic leak rates after TME.

General Surgery · Cureus · 25 Sept

Staged Reduction and Combined Anterior and Posterior Minimally Invasive Fixation for a Highly Unstable Open-Book Pelvic Ring Fracture: A Case Report

Computed tomography confirmed pubic symphysis reduction after external fixation, but posterior sacral fracture widening became apparent. Staged reduction and combined anterior and posterior minimally invasive fixation achieved satisfactory reduction and favorable functional recovery maintained at three years.

Orthopaedics · Cureus · 25 Sept

Postnatal Hypertension Management and Discharge Documentation: A Retrospective Clinical Audit at a UK University Hospital

Valid discharge BP recorded in 146/148 (98.6%), 118/146 (80.8%) below 140/90 mmHg. BP parameter plans documented in 27/148 (18.2%), two-week GP review in 34/147 (23.1%), clear discharge communication in 16/148 (10.8%).

Obstetrics & Gynaecology · Cureus · 25 Sept

Accuracy, Relevance, and Redundancy of ChatGPT-5.3 References in Open Fracture Management: A Methodological Analysis

11 of 45 references (24.4%) were fully accurate; 19 (42.2%) had bibliographic errors; 15 (33.3%) were unverifiable. Content relevance was 30 (66.7%).

Orthopaedics · Cureus · 25 Sept

High-Dose Tigecycline for Multidrug-Resistant Serratia Infections in Critically Ill Adults: A Systematic Review of Direct and Indirect Clinical Evidence

Evidence for high-dose tigecycline in resistant Serratia is indirect, so treat it as a last-line option and weigh the mortality signal before escalating the dose.

General Medicine · Cureus · 25 Sept

Anticoagulation Dilemma in a Patient With Pulmonary Embolism and Massive Haemoptysis

Haemoptysis worsened after starting apixaban and persisted despite dose adjustments; she was stabilised and discharged on warfarin. No laboratory or outcome figures reported.

General Medicine · Cureus · 25 Sept

Unmasking a Rare Triad of Iron Deficiency Anemia, Esophageal Web, and Dysphagia in Plummer-Vinson Syndrome: A Case Report and Review of the Literature

Severe microcytic hypochromic anemia with low serum ferritin and an esophageal stricture on barium swallow confirmed Plummer-Vinson syndrome; no outcome data reported.

Gastroenterology · Cureus · 25 Sept

Validation of the Nassar Preoperative Risk Scale to Predict Intraoperative Difficulty in Patients Undergoing Laparoscopic Cholecystectomy

Difficult LC occurred in 12.76%. Scale showed AUC 0.884, sensitivity 76.7%, specificity 87.8%, accuracy 86.4%, PPV 47.86%, NPV 96.26%.

General Surgery · Cureus · 25 Sept

IcoSema in Weight Management and Glycaemic Control: A Systematic Review and Meta-Analysis

A weekly insulin-semaglutide combo may cut injections while limiting insulin-related weight gain and hypoglycaemia, but heterogeneous comparators mean efficacy estimates remain uncertain.

Endocrinology · Cureus · 25 Sept

An Unsuspected Adult Intestinal Malrotation Presenting With Left-Sided Appendicitis, With the Diagnosis First Suggested by Purulent Drainage From the Appendiceal Orifice During an Elective Colonoscopy

Purulent drainage from the appendiceal orifice at colonoscopy; isolated left iliac fossa tenderness, no leukocytosis, 76% neutrophils, CRP 6.7 mg/dL; CT showed malrotation with inflamed appendix left of midline.

General Surgery · Cureus · 25 Sept

Radiotherapy versus observation following surgical resection of WHO grade 2 atypical meningioma (ROAM/EORTC-1308): an international, multicentre, open-label, phase 3, randomised controlled trial.

After complete resection of grade 2 meningioma, adjuvant radiotherapy delays recurrence but does not improve overall survival, so timing and patient selection matter more than routine referral.

Neurology · Lancet · 25 Sept

Redesigning cardiovascular medicine around sex differences.

Women's cardiovascular risk and presentation differ from men's; the evidence base you rely on was built mostly in men, so diagnostic thresholds and treatments may not fit your female patients.

Cardiology · Nature Medicine · 25 Sept

Unraveling the lexicon of complex mutational phenomena in human cancers.

No new data; the review clarifies ambiguous definitions and proposed origins of these eight phenomena and notes their reported associations with mutational processes, drug resistance and clinical outcomes

Oncology · Nature cancer · 25 Sept

Cardiac proteomic and phosphoproteomic profiling defines clinically relevant molecular subgroups in human heart failure.

Etiology-stratified analyses showed convergence to a shared end-stage proteomic landscape, but unbiased proteome-based clustering identified two molecular subgroups with divergent fibrosis and immune infiltration; subgrouping proteins also predicted survival in an independent plasma cohort.

Cardiology · Nature cardiovascular research · 25 Sept

Immunogenicity and safety of high-dose versus double-dose quadrivalent inactivated influenza vaccine in adult kidney transplant recipients: a randomized controlled trial (2023).

Seroconversion to at least one strain was 95.2% with high-dose versus 69% with double-dose (P = 0.002); absolute difference 0.26 (95% CI, 0.12-0.40). Injection site pain and myalgia were less common with high-dose.

General Medicine · Lancet regional health. Southeast Asia · 25 Sept

Diverse Clinical Spectrum of TTN-Truncation Variant Cardiomyopathy: A Case Series Illustrating Asymptomatic, Arrhythmic, Recurrent Takotsubo, and Inflammatory Phenotypes

Four cases: asymptomatic moderate LV systolic dysfunction found on screening; ventricular tachycardia storm needing multiple ablations and ICD shocks; two discrete takotsubo episodes; FDG-PET myocardial inflammation responding to corticosteroids

Cardiology · Cureus · 25 Sept

Perioperative Spinal Cord Stimulation Combined With Targeted Muscle Reinnervation for Chronic Neuropathic Pain: A Case Report

In amputees with refractory phantom limb pain, combining spinal cord stimulation with targeted muscle reinnervation may control pain when drugs alone fail, though this is a single case.

Anaesthesiology · Cureus · 25 Sept

Automated Tractography of Corticospinal and Corticoreticular Projections Originating From Brodmann Area 44 in Patients With Mild Stroke

FA was lower in the lesioned hemisphere for both BA44-origin corticospinal projections (0.484 vs 0.508, P = 0.011) and corticoreticular projections (0.442 vs 0.463, P = 0.049).

Neurology · Cureus · 25 Sept

Local Anesthetic Systemic Toxicity Following High-Volume Ropivacaine, Epinephrine, Clonidine, and Ketorolac (RECK) Infiltration During Total Knee Arthroplasty: A Case Report

Cumulative ropivacaine dose was 286 mg (3.9 mg/kg). Acute confusion and focal right arm myoclonic activity developed in the post-anesthesia care unit without cardiovascular instability; lipid emulsion produced rapid complete neurological recovery.

Anaesthesiology · Cureus · 25 Sept

A Case of Idiopathic Hypereosinophilic Syndrome With High WT1 (Wilms' Tumor Gene) mRNA

Markedly raised WT1 mRNA without blasts may flag occult myeloid malignancy in hypereosinophilia, so consider marrow WT1 testing before labelling it idiopathic.

General Medicine · Cureus · 25 Sept

Artificial Intelligence Versus Manual Measurement of Spinopelvic Sagittal Parameters Across Preoperative, Postoperative, and Instrumented Spines: A Systematic Review of Diagnostic Accuracy, Failure Rates, and Inferred Surgical Planning Implications

AI measures spinopelvic parameters accurately on preoperative films but fails more often on instrumented spines, so verify automated values before planning deformity correction.

Orthopaedics · Cureus · 25 Sept

Antimicrobial Resistance of Bacteria Isolated From Patients With Cancer

Enterobacteriaceae were 73.1% of isolates; ESBL prevalence 22.6%. E. coli MDR 51.0%, K. pneumoniae XDR 32.2%, Acinetobacter possible PDR 14.3%. E. coli resistance rose for ciprofloxacin and ceftriaxone in 2021.

Oncology · Cureus · 25 Sept

Psoriasis and Psoriatic Arthritis in Pregnancy: Current Evidence and Clinical Considerations

No primary data or effect sizes reported. Evidence suggests active or severe disease is linked to impaired fertility and worse pregnancy outcomes; flares are common postpartum despite pregnancy-related improvement in some women.

Obstetrics & Gynaecology · Cureus · 25 Sept

Left Inferior Pulmonary Vein Thrombosis and Secondary Lung Infarction Following Radiofrequency Catheter Ablation: A Diagnostic Challenge

Initial CT angiography read as isolated alveolar hemorrhage; repeat imaging at day 31 showed complete left inferior pulmonary vein thrombosis with secondary pulmonary infarction.

Cardiology · Cureus · 24 Sept

Lipedema-Related Outcomes During Gestrinone Treatment for Estrogen-Dependent Gynecological Disorders: A Real-World Retrospective Case Series

If gestrinone implants ease lipedema pain and limb volume alongside the gynaecological indication, it offers a dual-benefit option for women you already treat hormonally.

Obstetrics & Gynaecology · Cureus · 24 Sept

Bilateral Multifocal Serous Retinal Pigment Epithelial Detachments Coexisting With Generalized Rod-Cone Dysfunction Resembling Retinitis Pigmentosa

Multifocal serous PEDs with normal acuity can mask widespread rod-cone dysfunction, so consider ERG before attributing such detachments to central serous chorioretinopathy alone.

Ophthalmology · Cureus · 24 Sept

Cigna Group, OpenAI team up to support patients with complex conditions

Insurer-led AI navigation for cancer patients may change who coordinates your patients' care between visits, and what they bring to clinic.

Oncology · Fierce Healthcare · 24 Sept

Confirmed Myocarditis-Myositis Overlap Without Myasthenia Gravis: Evaluating for Triple M Syndrome Following Combined Enfortumab Vedotin and Pembrolizumab Therapy

Endomyocardial biopsy confirmed focal moderate lymphocytic myocarditis; troponin I, creatine phosphokinase, lactate dehydrogenase and transaminases were markedly elevated; acetylcholine receptor binding and muscle-specific kinase antibodies were negative.

Oncology · Cureus · 24 Sept

Inflammatory Eye Disease and Immunosuppressive Therapy: A Rheumatologist’s Perspective

Methotrexate and mycophenolate mofetil show comparable overall efficacy in randomised comparison; methotrexate favoured for posterior/panuveitis, mycophenolate for intermediate uveitis. Adalimumab has the strongest randomised evidence in noninfectious intermediate, posterior and panuveitis.

Ophthalmology · Cureus · 24 Sept

Cerebral/Cortical Visual Impairment in Primary Care: Extending the Evidence to Family Medicine

Family physicians rarely screen for CVI, a leading cause of childhood visual loss; asking about visual behaviour in children with developmental delay could catch it earlier.

Paediatrics · Cureus · 24 Sept

Overlapping Post-COVID Conditions: A Case of Myalgic Encephalomyelitis and Postural Orthostatic Tachycardia Syndrome Triggered by Sequential Epstein-Barr Virus (EBV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infections

Diagnosed with ME/CFS in early 2023 and POTS later that year; low-dose naltrexone, duloxetine and PEA with pacing gave only partial, fluctuating response.

General Medicine · Cureus · 24 Sept

Campylobacter rectus Thoracic Empyema in a Severely Malnourished Host With Preserved Conventional Immune Markers: A Case Report and Literature Review

Consider oral periodontopathogens like C. rectus in empyema when routine cultures are sterile, even if standard immune markers look normal.

General Medicine · Cureus · 24 Sept

Giant Postpartum Ovarian Mixed Germ Cell Tumor Containing Mature Cystic Teratoma and Yolk Sac Tumor: A Case Report With Multimodality Imaging and Clinicopathological Correlation

Postpartum abdominal distension and amenorrhea can mask a germ cell tumour; consider imaging and AFP before assuming benign postpartum change.

Obstetrics & Gynaecology · Cureus · 24 Sept

Clot Out, Flow Back: Large-Bore Aspiration Thrombectomy for Symptomatic Early Transjugular Intrahepatic Portosystemic Shunt (TIPS) Occlusion

Transjugular recanalisation with large-bore aspiration thrombectomy and balloon angioplasty restored shunt flow with no residual stenosis; portosystemic gradient fell from 21 to 13 mmHg, with symptom improvement.

Gastroenterology · Cureus · 24 Sept

STAT+: The rise of the AI-native radiology practice

AI-native practices that own their own scanners can train and deploy imaging models in-house, which may change who reads your scans and how fast reports return.

Radiology · STAT News — Health Tech · 24 Sept

Comparative Effectiveness and Safety of Rebamipide Versus Diquafosol in the Treatment of Dry Eye Disease: A Systematic Review and Meta-Analysis

No significant difference between rebamipide and diquafosol: tear break-up time SMD -0.21 (95% CI -0.52 to 0.11), symptom scores SMD 0.11 (95% CI -0.16 to 0.38), corneal staining SMD -0.002

Ophthalmology · Cureus · 24 Sept