Archive

Kidney Outcomes in Structural Heart and Cardiac Surgical Trials: The Case for Longitudinal Endpoint Reporting

Cardiac trial reports you rely on often omit longitudinal kidney outcomes, so post-procedure renal risk in your valve and surgical patients stays under-recognised.

Cardiology · Cureus · 22 Sept

Diagnosis, Treatment, and Current Controversies in Multiligament Knee Injuries: A Narrative Review

Single-stage anatomic reconstruction within two to three weeks is associated with less secondary meniscal and chondral injury. Functional outcomes deteriorate from seven years onward, with post-traumatic osteoarthritis in up to 71.7% of patients in some series.

Orthopaedics · Cureus · 22 Sept

Comparison of 25 µg Vaginal Misoprostol Versus Dinoprostone Gel for Induction of Labor in Term Prelabor Rupture of Membranes: A Retrospective Record-Based Observational Study

Induction-to-delivery 11.81 ± 3.06 vs 13.78 ± 3.99 hours (p < 0.001); oxytocin augmentation 16 (16.0%) vs 46 (46.0%) (p < 0.001); vaginal delivery within 24 hours 92 (92.0%) vs 94 (94.0%) (p = 0.780).

Obstetrics & Gynaecology · Cureus · 22 Sept

CD10-Positive Extranodal Marginal Zone Lymphoma of the Thyroid Arising in Hashimoto’s Thyroiditis: A Rare Diagnostic Challenge

In Hashimoto's patients with an FDG-avid thyroid nodule, consider marginal zone lymphoma and biopsy rather than assuming benign thyroiditis.

Endocrinology · Cureus · 22 Sept

Comparative Evaluation of the Vasodilatory Effects of Desflurane, Isoflurane, and Sevoflurane Using Perfusion Index During General Anaesthesia

Perfusion index on your existing pulse oximeter can track peripheral vasodilation differences between desflurane, isoflurane and sevoflurane without extra monitoring.

Anaesthesiology · Cureus · 22 Sept

Effects of Tirzepatide on Pancreatic β-Cell Function in Adults With Type 2 Diabetes Mellitus: A Systematic Review

Evidence that tirzepatide may preserve β-cell function, not just lower glucose, could shift when you start dual GIP/GLP-1 therapy in T2DM.

Endocrinology · Cureus · 22 Sept

Intramedullary Spinal Cord Metastasis From Oligometastatic Melanoma of Unknown Primary Treated With Stereotactic Body Radiotherapy

SBRT can control intramedullary cord metastases without surgery, so consider radiotherapy referral for oligometastatic melanoma patients with cord lesions and progressive myelopathy.

Oncology · Cureus · 22 Sept

Radiological Correlates of Headache and Papilledema in Patients Undergoing Cranial MRI: Clinical Relevance of the Evans Index and Fazekas Score

Incidental ventriculomegaly or white-matter changes on MRI may not explain your patient's headache or papilledema, so don't anchor the workup on these scores alone.

Neurology · Cureus · 22 Sept

American Medical Association urges CMS to stick to 2027 electronic PA deadline, enforcement

Electronic prior auth could cut the paperwork delays that stall your approvals, but only if CMS holds payers to the 2027 deadline.

Medicine · Fierce Healthcare · 22 Sept

STAT+: Epic’s mortality model, and Omada’s future products

Epic's mortality algorithm shapes which elderly patients get flagged for goals-of-care talks, so know its limits before trusting its score at the bedside.

General Medicine · STAT News — Health Tech · 22 Sept

Reliability and Validity of the Neonatal Pain, Agitation, and Sedation Scale in Mechanically Ventilated Neonates: A Systematic Review

N-PASS shows acceptable reliability and validity for titrating sedation in ventilated neonates, giving NICU teams a structured score where pain cannot be self-reported.

Paediatrics · Cureus · 22 Sept

Stereotactic Radiosurgery for an Unresectable Jugulotympanic Paraganglioma: Clinical Response and Acute Toxicity in a 70-Year-Old Patient

In elderly patients with unresectable skull-base paraganglioma, radiosurgery can control a slow-growing tumour while sparing nearby cranial nerves.

Oncology · Cureus · 22 Sept

Primary Glomus Tumor of the Inferior Vena Cava Diagnosed by Endovascular Biopsy: A Rare Incidental Finding

Imaging showed a 1.7-cm infrarenal IVC intraluminal abnormality; PET-CT showed no FDG-avid malignancy. Biopsy showed glomus tumor, later resected at 2.5 cm with Ki-67 <1%.

General Surgery · Cureus · 22 Sept

Occurrence of Heart Failure-Related Clinical Signs in a Japanese Convalescent Rehabilitation Ward: A Cross-Sectional Pilot Study

HF signs are common in rehab inpatients and often missed; screen for them before attributing breathlessness or fatigue to deconditioning.

Cardiology · Cureus · 22 Sept

Mode of Delivery and Perinatal Outcomes in Pregnancies With Absent End-Diastolic Flow: A Prospective Observational Study

In AEDF pregnancies beyond 28 weeks, this observational data on mode of delivery helps you weigh cesarean against vaginal birth when placental insufficiency is already advanced.

Obstetrics & Gynaecology · Cureus · 22 Sept

Blood test may help detect pancreatic cancer in earliest stages: Researchers

A sensitive stage 1-2 pancreatic cancer blood test could finally enable screening in high-risk patients, where CA19-9 and imaging currently miss early disease.

Oncology · ETHealthworld · 22 Sept

A Gallstone Masquerading as Hepatic Decompensation: A Case of Bouveret Syndrome

In cirrhotic patients with jaundice and distension, consider Bouveret syndrome: a migrated gallstone obstructing the pylorus can mimic hepatic decompensation and needs imaging, not just diuretics.

Gastroenterology · Cureus · 22 Sept

Celldex monoclonal antibody rebounds with pair of phase 3 wins for chronic skin condition

For patients with antihistamine-refractory chronic spontaneous urticaria, a KIT-targeting antibody now has phase 3 support, offering an alternative to omalizumab failures.

Medicine · Fierce Biotech · 22 Sept

Amgen’s Horizon-acquired fusion protein eases Sjögren's severity in ph. 3 win

If approved, dazodalibep would be the first targeted therapy for Sjögren's, offering an option beyond symptomatic dry-eye and dry-mouth management.

Medicine · Fierce Biotech · 22 Sept

Vertex’s midstage data amplify kidney disease market opportunity

Inaxaplin targets APOL1-mediated kidney disease, a genetic cause of rapid progression in patients of African ancestry; phase 2b signals efficacy beyond the pivotal trial population.

Urology · Fierce Biotech · 22 Sept

Parathyroid Storm Secondary to a Parathyroid Adenoma Presenting With Recurrent Generalised Tonic-Clonic Seizures and Refractory Hypercalcaemia: A Case Report

Refractory hypercalcaemia with seizures demands urgent parathyroidectomy, not just medical therapy; suspect parathyroid storm when calcium exceeds 4 mmol/L with neuropsychiatric decline.

Endocrinology · Cureus · 22 Sept

Efficacy of Magnesium Supplementation in Functional Constipation: A Systematic Review

4 of 7 studies showed significant between-group improvement in stool frequency; 4 of 6 reporting stool consistency showed significant between-group differences; both quality-of-life studies showed significant improvement.

Gastroenterology · Cureus · 22 Sept

Autoimmune Conversion of Hashimoto’s Thyroiditis to Graves’ Disease With Immune Pancytopenia in a Patient With Seropositive Rheumatoid Arthritis: A Diagnostic and Therapeutic Conundrum

In RA patients with cytopenias, check thyroid autoimmunity before starting antithyroid drugs, since conversion to Graves' can make ATD therapy hazardous.

Endocrinology · Cureus · 22 Sept

Otsuka heads to FDA as Ionis-partnered ALS drug hits primary phase 3 endpoint

A positive phase 3 in ALS gives your patients a new disease-modifying option and a likely expedited FDA pathway to access it.

Neurology · Fierce Biotech · 22 Sept

Development and Preliminary Validation of the SHUDE Scoring System for Chronic Endometritis in Women With Previous Reproductive Failure Undergoing In Vitro Fertilization Treatment

A composite hysteroscopic score may standardise chronic endometritis diagnosis in IVF patients with prior reproductive failure, where single findings are unreliable.

Obstetrics & Gynaecology · Cureus · 22 Sept

Association of Helicobacter pylori Infection With the Severity of Psoriasis

Small study links H. pylori to worse psoriasis; testing and treating the infection may be worth considering in patients with severe, refractory disease.

Gastroenterology · Cureus · 22 Sept

Siemens Healthineers and Novo team up on fatty liver disease awareness, testing

Industry-backed imaging and pharma partnership may widen access to liver stiffness and steatosis assessment, helping you identify MASLD patients earlier before cirrhosis develops.

Gastroenterology · Fierce Biotech · 22 Sept

The Pivotal Role of Consultant Physicians in the Early Screening, Diagnosis, and Management of Osteopenia and Osteoporosis: An Expert Opinion

Roughly half of Indian adults have osteopenia, so screen opportunistically and treat before the first fragility fracture, not after it.

General Medicine · Cureus · 22 Sept

The Prognostic Value of Baseline Neutrophil-to-Lymphocyte Ratio for Mortality in Idiopathic Pulmonary Fibrosis: A Systematic Review and Meta-Analysis

A cheap, routine CBC-derived NLR may help stratify mortality risk in IPF patients, guiding closer follow-up and earlier transplant referral without extra cost.

General Medicine · Cureus · 22 Sept

Ectopic Thyroid Tissue Mimicking a Thyroglossal Duct Cyst in a Child: A Diagnostic Pitfall Leading to Postoperative Hypothyroidism

Image the neck before excising a presumed thyroglossal duct cyst in a child — ectopic tissue may be the only thyroid, and removal causes permanent hypothyroidism.

Paediatrics · Cureus · 22 Sept

Cordis’ sirolimus drug-coated balloon earns FDA approval as a breakthrough device

A sirolimus-coated balloon now offers an alternative to repeat stenting for coronary in-stent restenosis, though Indian access and cost remain uncertain.

Cardiology · Fierce Biotech · 22 Sept

Critical Tracheal Compression by a Double Aortic Arch in a Young Infant: A Case Report

In a stridulous infant, consider a vascular ring before labelling it congenital airway disease; the ring is surgically correctable and imaging confirms it.

Paediatrics · Cureus · 22 Sept

Less Invasive Surfactant Administration Compared With Intubation-Surfactant-Extubation (INSURE), Nebulised Surfactant, and Continuous Positive Airway Pressure (CPAP) Alone in Preterm Infants With Respiratory Distress Syndrome: A Systematic Review

Versus CPAP alone, MIST halved intubation within 72 hours (36.5% vs 72.1%; RR 0.50, 95% CI 0.40-0.64; high certainty) and reduced pneumothorax. BPD among survivors fell (0.83, 0.70-0.98); death or BPD did not (0.87, 0.74-1.03).

Paediatrics · Cureus · 22 Sept

Diagnosis-Related Group Payment Systems and Hospital Efficiency, Quality, and Coding Behavior: A Systematic Review and Narrative Synthesis

DRG payment shifts hospitals toward efficiency but can drive upcoding and skimping on care; expect pressure on your documentation and discharge coding.

General Medicine · Cureus · 22 Sept

Renin-Angiotensin System (RAS) Inhibitors in High-Risk Patients With Type 2 Diabetes and Cardio-Renal Risk

Despite clear guideline backing, many high-risk T2D patients with cardio-renal risk are not on RAS inhibitors — check your own CKD and albuminuria patients.

Endocrinology · Cureus · 22 Sept

Infantile-Onset Pompe Disease: Current Therapeutic Landscape, Clinical Challenges, and Future Horizons

No trial data reported. Conventional enzyme replacement therapy improves cardiac function, motor development and survival, but is limited by lifelong intravenous infusions, immune responses and poor blood-brain barrier passage.

Paediatrics · Cureus · 22 Sept

Histopathology Versus Imaging: A Comparative Study of Liver Biopsy, Ultrasonography, and Triphasic Computed Tomography in Paediatric Patients With Chronic Liver Disease

In children with chronic liver disease, ultrasound and triphasic CT correlate imperfectly with biopsy, so imaging alone may understage fibrosis and delay referral.

Paediatrics · Cureus · 22 Sept

Sarcopenia in Chronic Obstructive Pulmonary Disease: Prevalence and Association With Disease Severity in an Indian Tertiary Care Cohort

Sarcopenia tracks with COPD severity in Indian patients, so screen muscle mass and strength in your COPD follow-ups, not just spirometry.

General Medicine · Cureus · 22 Sept

‘No Drain’ Strategy for Post-operative Orthopaedic Cases

Omitting closed-suction drains after orthopaedic surgery may cut transfusion needs, infection risk and hospital stay without raising hematoma or seroma rates.

Orthopaedics · Cureus · 22 Sept

Severe Pulmonary Hypertension in Critically Ill Children: A 10-Year Single-Center Case Series and Practical Management Considerations

All four presented with respiratory distress, hypoxaemia and cardiovascular compromise after recent respiratory infection. Median PICU stay 15 days (range 10-24). Two survived to discharge; two died of refractory pulmonary hypertensive crises.

Paediatrics · Cureus · 22 Sept