Archive

Flexible Laryngoscopy in Unexplained Cough: Institutional Outcomes and Community Practice Patterns

Before referring unexplained chronic cough, note that community practice patterns vary widely and laryngoscopy yield in this series may not justify routine early use.

General Medicine · Cureus · 22 Sept

Laminar Airflow vs. Conventional High-Efficiency Particulate Air (HEPA)-Filtered Ventilation in Primary Total Hip and Knee Arthroplasty: A Retrospective Comparative Cohort Study of 1,425 Patients

In 1,425 hip and knee arthroplasties, LAF showed no clear SSI advantage over conventional HEPA ventilation, so the costlier OR airflow system may not be justified.

Orthopaedics · Cureus · 22 Sept

Traumatic Macroglossia Associated With Clustered Epileptic Seizures in a Patient With Down Syndrome

In drug-resistant epilepsy with seizure clusters, tongue biting can cause macroglossia and acute airway obstruction; watch for tongue swelling after clustered tonic seizures.

Neurology · Cureus · 22 Sept

Anaconda Biomed snares $56M in funding for endovascular tech

Funds a pivotal trial of a next-gen aspiration catheter for large-vessel stroke thrombectomy, which may improve clot retrieval when current devices fail.

Neurology · Fierce Biotech · 22 Sept

Roche’s GLP-1/GIP drug hits in phase 2 diabetes trial, fueling best-in-disease hopes

Another dual GLP-1/GIP agonist reaching phase 2 endpoints expands the obesity-diabetes drug class your patients already ask about, though no head-to-head data yet.

Endocrinology · Fierce Biotech · 22 Sept

Hospitals told to step up monitoring, reporting of 'adverse events' related to medical devices

IPC's new guidance makes device-related adverse events a reportable hospital duty, so you should know your institution's reporting pathway for faulty devices.

Medicine · ETHealthworld · 22 Sept

Med device rules may get tougher: Govt plans new powers to stop manufacture, sale of unsafe, defective and spurious products, order destruction

Stronger recall and seizure powers mean devices you implant or prescribe could be pulled faster, so check batch notices and report suspected defects promptly.

Medicine · ETHealthworld · 22 Sept

Murine Typhus Masquerading as Thrombotic Thrombocytopenic Purpura in a Patient With Newly Diagnosed HIV

In febrile thrombocytopenia with renal failure, consider murine typhus before labelling TTP; doxycycline is curative and plasma exchange is not.

General Medicine · Cureus · 22 Sept

Glycyrrhizin-Induced Pseudoaldosteronism Contributing to Decompensated Heart Failure With Preserved Ejection Fraction

Ask heart failure patients about licorice and kampo preparations; stopping the culprit corrects hypokalemia and hypertension without diuretic escalation.

Cardiology · Cureus · 22 Sept

Proteome-wide genetic analyses identify ASGR1 as a potential biomarker linking smoking with ischemic heart disease.

ASGR1 may be the mediator between smoking and coronary disease, hinting at a target for risk stratification in smokers beyond standard risk factors.

Cardiology · Nature cardiovascular research · 22 Sept

Trastuzumab plus nivolumab with gemcitabine and cisplatin as first-line therapy for HER2-positive unresectable biliary tract cancer: a phase 1b/2 trial.

Adds HER2 blockade to first-line chemoimmunotherapy for HER2-positive biliary tract cancer; check HER2 status at diagnosis since this subset now has a targeted option.

Oncology · Nature Medicine · 22 Sept

Bioadaptive spatiotemporal nanomedicine promotes metabolic recovery after myocardial infarction through NAD(+) and UCP2 regulation.

Preclinical only: staged NAD+ release restored mitochondrial metabolism and limited remodeling in mice, so watch for human dosing and delivery data before it touches post-MI care.

Cardiology · Nature cardiovascular research · 22 Sept

Blood proteomics of menopause map to brain aging and dementia risk.

Menopause-linked blood proteins track with brain aging, suggesting a window to counsel and monitor women for later dementia risk.

Obstetrics & Gynaecology · Nature Medicine · 22 Sept

Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis.

Blood-based multicancer screening added to usual care did not reduce late-stage cancer diagnoses, so it should not be offered as a routine screen yet.

Oncology · NEJM · 22 Sept

Peripheral arterial disease: adverse impacts, disparities in outcomes, and the path ahead.

PAD affects over 300 million people worldwide, causing chronic pain, functional limitation, amputation, myocardial infarction, stroke and death, with burden concentrated in underserved groups.

Cardiology · Lancet · 22 Sept

Tobacco Use Treatment: Synopsis of the 2026 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline.

32 recommendations across 10 topic areas. Strong recommendations: motivational interviewing, FDA-approved pharmacotherapies, varenicline over other monotherapy, combination NRT over NRT monotherapy. Bupropion SR beyond 12 weeks was weak.

General Medicine · Annals · 22 Sept

Performance and safety of a multi-cancer early detection test: the PATHFINDER 2 study.

Cancer detection rate 0.54% (95% CI 0.47-0.63%); PPV 60.3%; NPV 99.2%; specificity 99.64%; episode sensitivity 39.3% all cancers, 69.8% in prespecified 12-cancer subgroup; number needed to screen 185.

Oncology · Nature Medicine · 22 Sept

Performance of a multi-cancer early detection test in the randomized controlled NHS-Galleri trial.

Primary endpoint of reduced stage III/IV cancer incidence was not met. Positive predictive value fell from 58.0% to 45.8% across rounds; episode sensitivity 26.7-37.2% for all cancers, 47.6-63.4% for 12 prespecified types.

Oncology · Nature Medicine · 22 Sept

An iron-regulated methionine redox axis governs adipose browning and cancer cachexia.

MsrA deletion impaired adipose browning, mitigated cachexia and prolonged survival of tumour-bearing mice. Iron-bound MSRA dimers promote browning by maintaining reduced protein kinase A catalytic subunit.

Oncology · Nature cancer · 22 Sept

Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence.

In external testing (8 centres, n=11,466), specificity was 98.5%, sensitivity 90.0% for cancer and 52.5% for precancerous lesions. Real-world low-dose screening (n=10,959) reached 99.94% specificity.

Oncology · Nature Medicine · 22 Sept

Current advancements in the care of peripheral arterial disease: modern approaches to medical, endovascular, and surgical treatment.

Amputation risk is low in asymptomatic PAD and intermittent claudication, with only a few progressing to chronic limb threatening ischaemia; supervised exercise improves walking capacity and avoids revascularisation risks

Cardiology · Lancet · 22 Sept

Emergency Management of Obstructing Ureteric Stones: A Closed-Loop Audit of Hot Ureteroscopy Uptake Against Getting It Right First Time (GIRFT) Standards

Audit your own emergency stone pathway: same-admission ureteroscopy avoids a stent and a second procedure, so defaulting to stenting costs patients an extra anaesthetic.

Urology · Cureus · 22 Sept

Spontaneous Mesenteric Hematoma Following Severe Coughing in a Patient on Dual Antiplatelet Therapy: A Case Report

On dual antiplatelet therapy, acute abdominal pain can be a spontaneous mesenteric hematoma, not a surgical abdomen; CT before the knife.

General Surgery · Cureus · 22 Sept

When Steroids Backfire: Tinea Incognito Following Treatment for Presumed Psoriasis

Steroid-treated plaques that worsen or lose their annular edge should prompt a KOH mount before you escalate immunosuppression.

General Medicine · Cureus · 22 Sept

Rapid Improvement of Persistent Catatonia Temporally Associated With Amantadine After Benzodiazepine Intolerance and Discontinuation of Electroconvulsive Therapy: A Case Report

When lorazepam is poorly tolerated and ECT cannot continue, amantadine may offer a rapid alternative for persistent catatonia, though this is a single case.

Psychiatry · Cureus · 22 Sept

Early Post-transcatheter Aortic Valve Implantation (TAVI) Haemodynamics With SAPIEN Balloon-Expandable and Evolut Self-Expanding Valve Platforms: A Retrospective Single-Centre Cohort Study

Valve choice at TAVI affects early gradients, so knowing how SAPIEN and Evolut differ helps you anticipate haemodynamics and follow-up echo findings.

Cardiology · Cureus · 22 Sept

Late-Onset Prosthetic Valve Dysfunction Associated With Hypoattenuated Leaflet Thickening Detected After a New Heart Murmur: A Case Report

A new murmur after sutureless bioprosthetic AVR may signal HALT; consider CT to detect leaflet thickening before overt valve failure develops.

Cardiology · Cureus · 22 Sept

Missed Early Signs of Tuberculosis in Pregnancy: Insights From a Case Series of Disseminated Life-Threatening Maternal Disease and Adverse Fetal Outcomes

All five had life-threatening disease: three of five had extensive pulmonary TB needing ventilatory support; one had tubercular meningitis with hydrocephalus; one had tubercular peritonitis with pyoperitoneum. Fetal outcomes included growth restriction, prematurity, demise, and congenital TB.

Obstetrics & Gynaecology · Cureus · 22 Sept

Vitamin D Supplementation in Granulomatous Disease: Why Individualized Assessment May Be Safer Than Universal Thresholds

No new data. Low 25(OH)D can occur with preserved or raised 1,25(OH)2D, so supplementing on 25(OH)D alone may cause hypercalcaemia or hypercalciuria.

General Medicine · Cureus · 22 Sept

Treatment-Resistant Psychosis in an Adolescent at Risk of Metabolic Syndrome: A Case Report

When metabolic risk rules out clozapine and other antipsychotics in a psychotic adolescent, you need a documented pathway through the remaining options.

Psychiatry · Cureus · 21 Sept

Pharmacokinetic, Pharmacodynamic, and Clinical Outcomes of Vancomycin and β-Lactam Antibiotics in Adults With Augmented Renal Clearance: A Systematic Review

Vancomycin troughs were below 10 µg/mL in more than 60% of ARC patients; AUC/MIC above 400 mg·h/L was reached in 82.14% with once-every-eight-hours dosing versus 46.42% with once-every-twelve-hours dosing.

General Medicine · Cureus · 21 Sept

Mini-Laparotomy Enterolithotomy for Gallstone Ileus in an Elderly Patient: A Case Report

In elderly patients with recurrent cholecystitis presenting as bowel obstruction, consider gallstone ileus and treat with enterolithotomy rather than a more extensive biliary procedure.

General Surgery · Cureus · 21 Sept

Central Centrifugal Cicatricial Alopecia in Black Women: Diagnostic Challenges and Molecular Insights

No pooled effect estimates reported. Dermoscopy and histopathology remain key to diagnosis, with follicular dropout, perifollicular fibrosis and lymphocytic inflammation; PADI3 and PPAR-gamma pathways are implicated but of uncertain clinical significance.

Medicine · Cureus · 21 Sept

Levamisole-Adulterated Cocaine-Associated Vasculopathy in a 73-Year-Old Woman: Diagnostic Challenges in Primary Care

In cocaine users with retiform purpura and atypical ANCA, suspect levamisole adulterant rather than primary vasculitis — misdiagnosis leads to unnecessary immunosuppression.

General Medicine · Cureus · 21 Sept

Medical groups, city of Columbus sue to challenge final Medicaid work requirements rule

If you see Medicaid patients, work-reporting rules from January could strip coverage unless courts block them, disrupting chronic-disease care.

General Medicine · Fierce Healthcare · 21 Sept

Democratic senators reintroduce bill outlining stiffer cybersecurity standards, $1.3B hospital implementation assistance

If passed, it would fund hospital cybersecurity upgrades and enforce standards, reducing the ransomware risk that can shut down your records and imaging mid-shift.

Medicine · Fierce Healthcare · 21 Sept

Artificial Intelligence and Anatomical Variation: A Narrative Review of Detection, Classification, and Educational Applications

Direct clinical evidence concentrated in dental and cranio-maxillofacial imaging; performance was task-, dataset- and prevalence-dependent, and external validation, calibration and transparent handling of correlated observations were uncommon.

Radiology · Cureus · 21 Sept

Clinical Profile and Outcomes of Children With Congenital Heart Disease Undergoing Surgery at a Tertiary Care Cardiac Center in Central Gujarat and Their Anthropometric Profiles During Follow-Up: A Prospective Longitudinal Observational Study

Baseline growth and surgical outcome data from non-metropolitan India help you counsel families on expected catch-up growth after CHD repair.

Paediatrics · Cureus · 21 Sept

Aetna expands bundled prior auths for cancer care

If your Medicaid cancer patients are Aetna-insured, one bundled auth now covers a whole regimen instead of separate approvals per drug and scan.

Oncology · Fierce Healthcare · 21 Sept

Alzheimer’s cases in India could be up to 5 times higher than reported number: Experts

Dementia is likely far more common than clinic figures suggest, so screen cognitively in older patients rather than waiting for memory complaints.

Neurology · ETHealthworld · 21 Sept