Archive

Delays, tech failures abound in CMS' WISeR AI prior auth pilot, documents show

If AI prior auth spreads to India, expect the same delays and denials; document your appeals now.

General Medicine · Fierce Healthcare · 15 Sept

Divergence Between Pain and Functional Recovery After Rotator Cuff Repair: A Prospective Comparative Analysis of Visual Analogue Scale, Constant-Murley Score, Disabilities of the Arm, Shoulder and Hand, and Shoulder Pain and Disability Index Scores

VAS improved 5.88 points, DASH 45.17, SPADI 41.55, but CMS only 6.80. VAS change correlated weakly with CMS (r = -0.34, p = 0.03) and DASH (r = 0.38, p = 0.01), and not with SPADI (r = 0.18, p = 0.27).

Orthopaedics · Cureus · 15 Sept

Sling reels in $123M series C to fund oral Tepezza rival through phase 3 trial

An oral alternative to IV Tepezza infusions could spare thyroid eye disease patients months of infusions if phase 3 confirms comparable efficacy.

Ophthalmology · Fierce Biotech · 15 Sept

Laryngeal vs. Esophageal Acid-Mediated Injury in Bulimia Nervosa: A Systematic Review

Laryngeal mucosa showed earlier and more severe pathological changes than esophageal mucosa in bulimia nervosa patients, attributed to lower acid-exposure tolerance, thinner epithelium, and reduced mucosal buffering capacity.

Gastroenterology · Cureus · 15 Sept

A Comparative Outcomes Study: Is Routine Hip Abduction Bracing Necessary After Gluteus Medius Repair?

Combined six-month complication and reoperation rate was 10 (11.6%) without bracing versus 9 (11.8%) with bracing; p=0.966. Reoperations 0% versus 2 (2.6%); p=0.219.

Orthopaedics · Cureus · 15 Sept

Acute Urinary Retention Leading to Post-renal Acute Kidney Injury Post-radiotherapy: A Case Report

Eight days post-radiotherapy, AUR with overflow incontinence and post-renal AKI; creatinine fell from 4.89 mg/dL to 1.46 mg/dL after Foley decompression. TURP later relieved catheter dependence.

Urology · Cureus · 15 Sept

Van Wyk-Grumbach Syndrome: A Rare Triad of Precocious Puberty, Pituitary Pseudomacroadenoma, and Multicystic Ovaries in an Eight-Year-Old Girl

Bone age was delayed to 3.5-4 years and thyroid profile confirmed autoimmune primary hypothyroidism; the patient was managed purely medically with cautious levothyroxine, avoiding surgery

Paediatrics · Cureus · 15 Sept

Most health systems deploy AI tools without formal IT approval. What are the risks?

Unvetted AI tools touching patient data bypass your hospital's security review, so ask whether the scribe or triage app you use was IT-approved.

Medicine · Fierce Healthcare · 15 Sept

Inflammatory Papillary Hyperplasia: A Diagnostic Challenge to Oral Physicians

Inflammatory papillary hyperplasia presented on the labial aspect of the edentulous mandibular anterior alveolar ridge, a rare site; palate is the usual location

Medicine · Cureus · 15 Sept

STAT+: Medicare to expand its pilot that pays for technology to manage chronic diseases

Expanded Medicare coverage of remote monitoring signals a coming reimbursement pathway for chronic-disease tech, worth watching if you run diabetes or hypertension clinics.

General Medicine · STAT News — Health Tech · 15 Sept

Smokeless Tobacco Pouch Keratosis: A Report of Two Cases

Both patients had thick whitish wrinkled lesions along the vestibule or gingiva at the site of smokeless tobacco contact; both received nicotine replacement therapy to quit.

Oncology · Cureus · 15 Sept

Demographic Factors Influencing the Need for Repeat Radiofrequency Ablation in Chronic Pain Management: A Retrospective Study

Race, sex, age and BMI may predict who needs repeat radiofrequency ablation, so you can counsel chronic pain patients on likely retreatment before the first procedure.

Anaesthesiology · Cureus · 15 Sept

Beyond Prognosis: A Systematic Review of the Neutrophil-to-Lymphocyte Ratio as a Modifiable Cardiovascular Biomarker

IL-6 inhibition gave the clearest dose-dependent NLR reduction; glutathione, cardiac rehabilitation, time-restricted eating, curcumin and hyperoxia also looked favourable. SGLT2 inhibitor results were inconsistent. Clinical outcomes were rarely reported and underpowered.

Cardiology · Cureus · 15 Sept

FDA Launches Expedited IND Pilot, Begins Accepting Applications

Faster IND clearance could shorten the wait before first-in-human trials of novel agents reach your patients.

Medicine · FDA — Press Announcements · 15 Sept

FDA launches pilot program to speed up sluggish phase 1 trials

Faster US phase 1 starts could bring novel drugs to your patients sooner, but early safety data may be thinner at first read.

Medicine · Fierce Biotech · 15 Sept

Assessing the Growing Impact of Oral GLP-1 Agonists on National Obesity Policies of the United Kingdom

No original data. The authors discuss access inequalities and state provision of oral GLP-1 receptor agonists, and argue these drugs should augment, not replace, established weight-management methods.

Endocrinology · Cureus · 15 Sept

STAT+: New documents reveal problems with Medicare’s prior-authorization pilot

If AI-driven prior authorization spreads, expect more denials and appeals paperwork for your Medicare patients' imaging, procedures and referrals.

General Medicine · STAT News — Health Tech · 15 Sept

Improving Engagement With Breast Cancer Screening Through Structured Telephone Outreach Among Uninsured Women

Of 361 patients, 110 (30.5%) were contacted; 70 (63.6%) accepted referral. Mammography completion was 2.9% at 30 days and 4.3% at 60 days; 74.3% of referred patients had no follow-through

Oncology · Cureus · 15 Sept

Ayble Health banks $16M series A to expand AI-driven precision digestive, autoimmune healthcare

A funded AI platform for GI and autoimmune care may reach your patients through their insurers, so know what it offers before they ask.

Gastroenterology · Fierce Healthcare · 15 Sept

Combination of Technologies in Body Contouring: Evidence Mapping and a Decision-Making Algorithm

Surgical-energy pairings, chiefly radiofrequency-assisted and helium plasma-assisted liposuction, gave the most consistent additive skin retraction with acceptable safety; non-invasive pairings gave measurable but modest fat and muscle gains.

General Surgery · Cureus · 15 Sept

Uterocervical Angle (UCA) Combined With the Bishop Score as a Predictor for Successful Induction of Labor in Term Pregnancy: A Prospective Observational Study

UCA ≥107.25° gave 57.3% sensitivity and 72.8% specificity; Bishop score ≥4 gave 59.3% and 72.8%. Combined criteria (UCA ≥107.25° or Bishop score ≥4) reached 80.6% sensitivity and 64.1% specificity.

Obstetrics & Gynaecology · Cureus · 15 Sept

Memantine-Induced Sialorrhea: A Rare Adverse Reaction and Review of Pathophysiological Mechanisms

If a dementia patient on memantine develops unexplained drooling, consider the drug as the cause rather than assuming progression or a new neurological deficit.

Neurology · Cureus · 15 Sept

Prevalence of Mild Autonomous Cortisol Secretion Among Patients With Adrenal Incidentaloma and Its Association With Metabolic Abnormalities: A Hospital-Based, Analytical, Cross-Sectional Study

MACS in 95 (25.0%). Adjusted associations: obesity aOR 1.85 (1.09-3.14), diabetes aOR 1.68 (1.01-2.80), metabolic syndrome aOR 1.82 (1.11-2.98); lesion size aOR 1.38 per cm (1.14-1.67).

Endocrinology · Cureus · 15 Sept

Fatal Pulmonary Tumor Thrombotic Microangiopathy Associated With Disseminated Carcinomatosis of the Bone Marrow From Occult Gastric Cancer: An Autopsy-Confirmed Case

Bone marrow biopsy confirmed disseminated carcinomatosis; autopsy showed type 4 gastric adenocarcinoma with pulmonary tumor microemboli and fibrocellular intimal proliferation causing fatal respiratory failure.

Oncology · Cureus · 15 Sept

Phenotypic Characterization of Multidrug-Resistant Pseudomonas aeruginosa Isolated From Patients With Ventilator-Associated Pneumonia: Insights Into Resistance Mechanisms and Biofilm Formation

Complete resistance to piperacillin and imipenem (100% each), piperacillin-tazobactam and meropenem 98.08% each; aztreonam most susceptible (83.65%). MBL production in 80 (76.92%), ESBL in 7 (6.73%). Biofilm in 54 (51.92%) by tube method.

General Medicine · Cureus · 15 Sept

Prevention and Management of Pediatric Sensitive Skin Conditions in India: A Modified Delphi Consensus

Experts unanimously agreed diaper dermatitis, xerosis and atopic dermatitis are the most prevalent paediatric sensitive skin conditions; emollients were recommended as the cornerstone of management, with colloidal oatmeal emollients favoured in xerosis and atopic dermatitis.

Paediatrics · Cureus · 15 Sept

Pediatric Rosai-Dorfman-Destombes Disease: From Isolated Cervical Lymphadenopathy to Multisystem Disease

Consider RDD in a child with persistent cervical lymphadenopathy, since the same disease can progress from a single node to multisystem involvement.

Paediatrics · Cureus · 15 Sept

A Rare Encounter With Peripheral Dentinoma: Clinicopathological Insights

Microscopy showed a disorganized mass of tubular dentin with sclerotic, atubular eosinophilic dentinoid areas, confirming dentinoma; the preoperative provisional diagnosis was foreign body.

Medicine · Cureus · 15 Sept

Congenital Bile Acid Synthesis Defect Type 2 Mimicking Biliary Atresia: A Case Report of Delta-4-3-Oxosteroid 5-Beta-Reductase Deficiency in a Two-Month-Old Infant

Urine LC-MS/MS showed trace primary bile acids with Δ4-3-oxo intermediates; NGS confirmed CBASD type 2. Liver biopsy showed giant cell hepatitis without ductal proliferation, excluding BA.

Paediatrics · Cureus · 15 Sept

Evvy raises $40M to expand precision medicine for vaginal health

A clinician-reviewed at-home vaginal microbiome test with treatment plans may reach your patients before you do; know what it reports and its limits.

Obstetrics & Gynaecology · Fierce Healthcare · 15 Sept

STAT+: Medicare’s AI prior authorization pilot was rushed and full of problems, new documents reveal

If AI-driven prior authorization spreads, expect more denials and delays for your Medicare patients; document necessity carefully and appeal with clinical detail.

General Medicine · STAT News — Health Tech · 15 Sept

Gastric Ischemia Secondary to Atherosclerotic Disease: A Case Report and Literature Review

CT angiography showed near-complete coeliac trunk occlusion, 3-cm severe superior mesenteric artery stenosis with near-occlusion, and 40% inferior mesenteric artery stenosis. Stenting resolved symptoms and achieved complete endoscopic mucosal healing.

Gastroenterology · Cureus · 15 Sept

Comparison of Sugammadex and Neostigmine for Reversal of Vecuronium-Induced Neuromuscular Blockade in Pediatric Patients: A Prospective Randomized Study

Median time to TOF ≥0.9 was 70 (65-108) vs 252 (240-280) seconds, and to TOF 1.0 was 85.5 (75-142) vs 272 (255-304) seconds, sugammadex vs neostigmine, p = 0.001.

Anaesthesiology · Cureus · 15 Sept

Medication Adherence in Patients With Glaucoma and Determinants of Treatment Adherence: A Cross-Sectional Study

Full adherence reported by 55.8% (43/77). Adherence associated with glaucoma severity (p=0.002), education (p<0.001), income (p<0.001), clinician-patient communication (p<0.001), follow-up (p=0.03), motivation (p<0.001), memory (p<0.001), drop difficulty (p=0.001), side effects (p<0.001)

Ophthalmology · Cureus · 15 Sept

Persistent Diarrhea Due to Cyclospora cayetanensis Diagnosed by Multiplex GI PCR in a Patient With HIV: A Case Report

Conventional bacterial stool culture identified no enteric pathogen and ciprofloxacin did not help; multiplex GI PCR detected C. cayetanensis, treated with TMP-SMX 160/800 mg twice daily for 10 days

Gastroenterology · Cureus · 15 Sept

Evaluation of Alterations in Serum Uric Acid Levels in Newly Diagnosed Overt Thyroid Dysfunction: A Prospective Observational Study From a Tertiary Care Center

Uric acid was higher in thyroid dysfunction than controls (5.62 ± 2.28 vs. 4.46 ± 1.13 mg/dL, p < 0.001); creatinine was lower (0.86 ± 0.16 vs. 0.92 ± 0.22 mg/dL, p = 0.010). Uric acid AUC 0.642, cutoff 4.05 mg/dL, 71.3% sensitivity.

Endocrinology · Cureus · 15 Sept

Effectiveness of Virtual Reality-Based Rehabilitation on Balance, Gait, and Functional Independence in Patients With Parkinson’s Disease: Implications for Healthy Longevity

Berg Balance Scale improved +8.97 versus +4.52 points, TUG −3.51 versus −1.79 seconds, gait speed +0.234 versus +0.111 m/s; 108 of 125 (86.4%) versus 34 of 125 (27.2%) reached lower fall-risk category.

Neurology · Cureus · 15 Sept

After rejection, FDA approves Telix’s Pixclara, the first FET-PET imaging drug for brain cancer

FET-PET distinguishes true tumour progression from post-treatment pseudoprogression in glioma, sparing patients unnecessary biopsy or therapy change.

Oncology · Fierce Biotech · 15 Sept

J&J’s Contineum-partnered depression drug flunks another phase 2 test

A second phase 2 miss for JNJ-5120 means this mechanism is unlikely to reach your treatment-resistant depression patients; keep current options.

Psychiatry · Fierce Biotech · 15 Sept

Modern Obesity Treatment: Efficacy, Safety, and Future Directions of GLP-1 (Glucagon-Like Peptide-1) and GIP (Glucose-Dependent Insulinotropic Polypeptide) Receptor Agonists

Liraglutide established GLP-1 agonism for weight management; semaglutide gave greater, more sustained weight reduction; tirzepatide produced greater weight loss than semaglutide in direct comparative studies.

Endocrinology · Cureus · 15 Sept