Archive

Indian AI platform for cancer care featured in BRICS health journal

AIIMS-built decision support for cancer care is now peer-visible, so Indian oncologists may soon see it offered in their own workflows rather than imported tools.

Oncology · ETHealthworld · 15 Sept

Interrater Reliability of the Modified Tuck Jump Assessment Scored by Physical Therapy Students

Total score interrater reliability was excellent (ICC(2,1) = 0.868; 95% CI, 0.775-0.924), but item-level linear-weighted kappa ranged from 0.30 to 0.78, with six of 10 items not reaching substantial agreement.

Orthopaedics · Cureus · 15 Sept

Virological and metabolic outcomes after switching to dolutegravir or rilpivirine in virologically suppressed adults with HIV in Thailand: an open-label, randomised, controlled, non-inferiority trial.

In suppressed patients on efavirenz, switching to dolutegravir or rilpivirine kept viral suppression but differed in weight and metabolic effects, informing which switch suits whom.

General Medicine · Lancet regional health. Southeast Asia · 15 Sept

Broadly neutralizing antibodies in adult males living with HIV undergoing analytical treatment interruption: secondary and exploratory outcomes of the phase II randomized controlled RIO trial.

Rebounding virus showed significant selection for resistance to 10-1074-LS but not 3BNC117-LS. Greater baseline reservoir sensitivity to autologous antibodies and 10-1074 correlated with longer time to rebound.

General Medicine · Nature Medicine · 15 Sept

Age-associated loss of lymphatic vessels promotes cardiac inflammation.

Aging lowered cardiac lymphatic density in humans and mice, with immune infiltration, fibrinogen and amyloid accumulation and myocardial edema; Vegfc overexpression or Il33 silencing restored lymphatic density and homeostasis in aged hearts.

Cardiology · Nature cardiovascular research · 15 Sept

Evaluation and Management of Anemia in Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2026 Clinical Practice Guideline.

Eight graded recommendations: iron guided by transferrin saturation and ferritin, intravenous iron preferred over oral in hemodialysis, correctable causes addressed first, ESA preferred over HIF-PHI first-line, upper Hb target below 11.5 g/dL.

General Medicine · Annals · 15 Sept

Cryo-EM structures of Candida albicans chitin synthase Chs1 reveal a druggable translocation channel.

DA binds the chitin translocation channel, occluding polymer extrusion, and shows potent synergy with nikkomycin Z against C. albicans and C. auris.

General Medicine · Nature microbiology · 15 Sept

A Synopsis of the 2025 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline for Lipid Management for Cardiovascular Disease Risk Reduction.

New: PREVENT calculator for primary prevention risk estimation; routine lipid monitoring no longer discouraged; coronary artery calcium for intermediate-to-high risk with uncertainty; one-time lipoprotein(a) testing; moderate-intensity statins for adults with HIV even at low 10-year risk.

Cardiology · Annals · 15 Sept

On-premise medical AI agents for reliable clinical decision-making.

Accuracy was 90.04% on the seven-disease task and 83.8% on the four-disease task. Diagnostic behavioural consistency best predicted correctness (AUC 0.860; 0.875 under stress testing). At threshold 0.90, 49.4% of cases retained at 98.9% accuracy.

General Medicine · Nature Medicine · 15 Sept

The Potential Therapeutic Effects of Testosterone on Sarcopenia: A Thorough Systematic Review

Testosterone may modestly improve muscle mass and strength in older adults with sarcopenia, but evidence on falls and function remains weak — counsel patients before prescribing.

Endocrinology · Cureus · 15 Sept

As ‘cultural weight’ of a psychedelic approval looms, FDA hearing focuses on access and safety

If MDMA-assisted therapy is approved, you will need to know referral pathways, monitoring requirements and how to counsel patients about supervised psychedelic treatment.

Psychiatry · Fierce Healthcare · 14 Sept

As ‘cultural weight’ of a psychedelic approval looms, FDA hearing focuses on access and safety

If MDMA-assisted therapy is approved, you will need to know its monitoring requirements and how patients access it, since real-world safety data remain limited.

Psychiatry · Fierce Biotech · 14 Sept

Bias Mitigation Across the Healthcare Artificial Intelligence Lifecycle: A Structured Narrative Review

No primary quantitative result; the review catalogues sampling, adversarial learning, subpopulation techniques, and new model structures, and proposes a lifecycle protocol spanning data acquisition to deployment

General Medicine · Cureus · 14 Sept

GE HealthCare launches AI-driven operations system

If it reliably flags bed and theatre crunches 72 hours out, it could change how you schedule admissions and elective lists.

Medicine · Fierce Healthcare · 14 Sept

Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine for Wound Infiltration After Caesarean Section Under Spinal Anaesthesia

Tramadol use over the first day was lowest with dexmedetomidine (87.33 ± 17.40 mg), then dexamethasone (129.43 ± 15.61 mg), then bupivacaine alone (150.33 ± 14.59 mg); P<0.0001.

Anaesthesiology · Cureus · 14 Sept

Molecular Etiology and Mortality Risk Stratification of Non-SARS-CoV-2 Severe Acute Respiratory Infection in a Predominantly Pediatric Cohort: A Retrospective Study From a Tertiary Care Hospital in North India

In North Indian children with non-COVID SARI, the ViVI severity score may help you flag those at higher mortality risk early and target escalation.

Paediatrics · Cureus · 14 Sept

Perfusion Index as a Predictor of Hypotension Following Spinal Anesthesia in Below-Umbilical Surgeries

21 of 92 (22.8%) developed hypotension. Baseline PI was higher in those who did (4.38±1.67 vs 1.51±0.53, P<0.001). PI ≥2.53 gave 100% sensitivity, 98.6% specificity, AUC 0.999.

Anaesthesiology · Cureus · 14 Sept

Potential new TB vaccines could save millions of lives: Gavi

If new TB vaccines reach India's immunisation schedule, they could cut a disease you still diagnose weekly in young adults and children.

General Medicine · ETHealthworld · 14 Sept

Red Cell Distribution Width-to-Platelet Count Ratio as an Early Marker of Severity in Acute Pancreatitis: A Diagnostic Accuracy Study at a Tertiary Care Center

A single admission CBC-derived ratio may flag severe acute pancreatitis before 48-hour scores are available, letting you escalate care earlier.

Gastroenterology · Cureus · 14 Sept

Emergency Department Management of Ankle Fractures: A Narrative Review

Half of ankle fractures follow simple falls and a quarter need surgery, so your ED workup and splinting decisions determine who gets timely orthopaedic referral.

Orthopaedics · Cureus · 14 Sept

States are betting millions on remote monitoring. Providers, tech groups say proposed Medicare policy could undercut it

If Medicare cuts remote monitoring reimbursement, the RPM programmes your rural patients depend on may lose funding, so check whether your service is exposed.

General Medicine · Fierce Healthcare · 14 Sept

The Impact of Assisted Reproduction Technology on Breast Cancer Risk for Women With Infertility: Current Insights and Future Perspectives

No consistent evidence links ovarian stimulation to breast cancer, so you can counsel infertility patients that ART has not been shown to raise their risk.

Obstetrics & Gynaecology · Cureus · 14 Sept

Prevalence and Pattern of Thyroid Dysfunction Among Women of Reproductive Age With Abnormal Uterine Bleeding: A Prospective Observational Study

Thyroid dysfunction in 45/150 (30.0%): overt hypothyroidism 19/45 (42.2%), subclinical hypothyroidism 16/45 (35.6%), overt hyperthyroidism 10/45 (22.2%). Mean TSH 6.20 ± 4.89 vs 2.54 ± 0.96 mIU/L (p < 0.001).

Obstetrics & Gynaecology · Cureus · 14 Sept

Axoltis misses the mark in phase 2 ALS study, but still strives to move towards the clinic

A negative phase 2 in ALS means no new option is imminent; continue standard multidisciplinary care and consider enrolling patients in other ongoing ALS trials.

Neurology · Fierce Biotech · 14 Sept

Knowtex launches frontier healthcare AI lab

A vendor already used across 200+ specialties is expanding its AI platform, so expect more ambient documentation and coding tools pitched to your hospital.

Medicine · Fierce Healthcare · 14 Sept

Extensor Mechanism Reconstruction Following Periprosthetic Joint Infection After Total Knee Arthroplasty: A Systematic Review

No formal comparison established superiority or equivalence of allograft versus synthetic mesh. Postoperative Knee Society Scores frequently exceeded 70 points, extensor lag improved to less than 10°, and flexion ranged from 95° to 110°.

Orthopaedics · Cureus · 14 Sept

Corbus posts phase 1 obesity data for drug mechanism that defeated Novo, Sanofi

A peripherally restricted CB1 inverse agonist may deliver weight loss without the neuropsychiatric toxicity that ended earlier CB1 obesity programmes; phase 2 will test that claim.

Endocrinology · Fierce Biotech · 14 Sept

AI, trauma, bionics: India’s top institutes join forces to develop medical care for soldiers

Trauma and bionics protocols developed for battlefield injuries will likely flow into civilian emergency and orthopaedic practice at these institutes.

General Surgery · ETHealthworld · 14 Sept

The Effect of Oral Isotretinoin on Quality of Life in Patients With Acne Vulgaris: A Systematic Review and Meta-Analysis of Patient-Reported Outcomes

Pooled DLQI fell significantly after isotretinoin: SMD −1.49 (95% CI −2.48 to −0.51). Heterogeneity was substantial (I² = 98.1%). Mixed-severity and severe or treatment-resistant subgroups both improved, with no significant difference between them.

Medicine · Cureus · 14 Sept

Persistent HyperCKemia Beyond Post-Viral Myositis: A Case of Anti-HMGCR Immune-Mediated Necrotizing Myopathy

CK fell to 376 U/L (N 30-200 U/L) four months after admission on high-dose corticosteroids then methotrexate, with complete recovery of muscle strength and swallowing.

Neurology · Cureus · 14 Sept

Disciform Keratitis That Improves With Poly(Adenosine Diphosphate-Ribose) Polymerase Inhibitor Treatment for Ovarian Cancer but Recurs Upon Discontinuation of Treatment

VZV DNA detected in aqueous humour by PCR. Keratitis resolved with oral valacyclovir and topical betamethasone, recurred one month after olaparib stopped, and resolved again with frequent topical betamethasone.

Ophthalmology · Cureus · 14 Sept

Rhabdomyolysis Following Rapid Correction of Acute Hyponatraemia in a Patient With Psychogenic Polydipsia

Serum sodium rose from 117 mmol/L to 131 mmol/L within six hours; CK was already elevated on admission and peaked at 60,672 U/L, with preserved renal function.

General Medicine · Cureus · 14 Sept

India may get own dengue vax by next year end: ICMR DG

A single-dose indigenous vaccine covering all four serotypes could reach Indian clinics by late 2026, but low case counts may delay trial unblinding.

General Medicine · ETHealthworld · 14 Sept

Roche, MediLink notch phase 3 lung cancer win but trail GSK on cross-trial survival

A new B7-H3 ADC option is coming for relapsed SCLC, but its median survival trails GSK's rival, so sequencing and cross-trial comparisons will matter.

Oncology · Fierce Biotech · 14 Sept

Renal Dysfunction and Cardiorenal Syndrome in Acute Heart Failure: A Systematic Review of Residual Congestion and Decongestion Response

Residual congestion was consistently associated with worse clinical outcomes, while worsening renal function during effective decongestion did not uniformly predict adverse renal or cardiovascular events.

Cardiology · Cureus · 14 Sept

Quantitative Neuromuscular Monitoring in General Anesthesia: A Systematic Review of Recovery and Safety Outcomes

TOF ratio of at least 0.90 was the common threshold for adequate recovery; residual blockade was associated with oxygen requirement, hypoxemia, critical respiratory events, and pulmonary complications.

Anaesthesiology · Cureus · 14 Sept

Late-Onset Neonatal Cyanosis Secondary to Methemoglobinemia in a Preterm, Small-for-Gestational-Age Infant: A Case Report

In a preterm neonate with unexplained desaturations unresponsive to oxygen, check methemoglobin — methylene blue and vitamin C correct it, and pulse oximetry alone will mislead you.

Paediatrics · Cureus · 14 Sept

Global nutrition experts back FSSAI warning labels, seek stricter rules

Stricter front-of-pack warnings on high sugar, salt and saturated fat could make packaged-food counselling easier for patients with diabetes, hypertension and obesity.

General Medicine · ETHealthworld · 14 Sept

Manipal Hospitals scouts for acquisitions in Andhra, Keralam, Delhi-NCR; bets on AI-led healthcare

Your hospital's competitor is scaling AI-assisted nursing and monitoring across 2,400 new beds, which will shift referral patterns and staffing expectations in these regions.

Medicine · ETHealthworld · 14 Sept

Managing Cardiac Amyloidosis in a Rural Cardiology Practice: Bridging Gaps in Specialized Evaluation and Disease-Modifying Treatment

All three patients were effectively evaluated using a streamlined diagnostic pathway and started on disease-modifying therapy promptly, despite limited access to advanced imaging, biopsy and genetic testing

Cardiology · Cureus · 14 Sept