Archive

Beyond clinical endpoints: Rethinking ALS drug development through disease biology

If biology-driven endpoints replace survival and ALSFRS-R in ALS trials, the drugs you can offer patients may change faster than current approval standards allow.

Neurology · Fierce Biotech · 11 Sept

ARPA-H launches $63M effort to build FDA-authorized AI agents for heart failure care

Autonomous AI agents for heart failure could soon reach your clinic with FDA oversight, so watch how these tools are validated before adoption.

Cardiology · Fierce Healthcare · 11 Sept

PHTI report finds limited impact from virtual kidney care solutions, prompting industry pushback

Before referring CKD patients to virtual kidney programmes, note this review found limited evidence of benefit, though vendors dispute the methodology.

General Medicine · Fierce Healthcare · 11 Sept

The future of RAS inhibitors

RAS inhibitors are moving beyond one approved drug for pancreatic cancer, so expect more targeted options for KRAS-mutant tumours in coming years.

Oncology · Fierce Biotech · 11 Sept

FDA delays approval decision for Exelixis' tyrosine kinase inhibitor in colorectal cancer

A potential oral option added to atezolizumab for metastatic colorectal cancer is pushed back, so keep current regimens unchanged for now.

Oncology · Fierce Biotech · 11 Sept

Tricuspid Stenosis Due to Cardiac Sarcoma

Echocardiography showed a large right atrial mass obstructing tricuspid inflow plus significant pericardial effusion; resection confirmed biphasic synovial sarcoma. Postoperatively he developed atrial flutter with left ventricular dysfunction needing cardioversion.

Cardiology · Cureus · 11 Sept

Variability of Nutritional Status During Hematopoietic Stem Cell Transplantation and Its Association With Clinical Outcomes: An Ambispective Observational Study From India

Mean weight fell from -1.80% at day 0 to -7.65% at day +30. At day +60, weight loss was greater with viral infections (-14.7% vs -5.4%; p=0.03) and stays >36 days (-14.6% vs -5.3%; p=0.025).

Oncology · Cureus · 11 Sept

BioNTech sets survival standard in hard-to-treat cancer ahead of pivotal readout

In relapsed lung cancer, gotistobart achieved 18.5-month median overall survival, exceeding current standard-of-care benchmarks; confirmatory pivotal data are still pending.

Oncology · Fierce Biotech · 11 Sept

STAT+: An AI tool aims to catch harder-to-detect heart attacks in EKGs

An AI ECG reader cleared to flag occult coronary occlusion could catch NSTEMI and posterior MI patterns that clinicians and standard algorithms miss.

Cardiology · STAT News — Health Tech · 11 Sept

Lower Extremity Salvage Through Dextranomer Debridement and Evolution Toward a Functional Pincer in a Diabetic Foot: Experience in Rural Surgery

Serial topical dextranomer microbeads controlled exudate and fibrin, halted necrotic progression, and produced a clean granulating wound bed; the patient avoided proximal amputation after an 18-day hospital stay.

General Surgery · Cureus · 11 Sept

Evaluation of Tooth Shade Selection With Conventional Methods and Artificial Intelligence-Integrated Methods: A Comparative Study

Exact shade agreement 78.2% with AI versus 49.1% conventional; Cohen's kappa 0.75 vs 0.43; accuracy 87.3% vs 74.5%; mean CIEDE2000 1.42 vs 1.76.

Medicine · Cureus · 11 Sept

Hyperglycemic Hyperosmolar State As the Initial Presentation of Type 1 Diabetes Mellitus in an Adolescent: A Case Report

Glucose exceeded 1,000 mg/dL with hyperosmolality, dehydration and only mild acidosis; treatment caused marked glucose swings needing repeated insulin and dextrose titration.

Paediatrics · Cureus · 11 Sept

Effectiveness and Patient Compliance of a Needle-Free Injection System in Controlled Ovarian Stimulation in IVF Cycles: A Real-World, Investigator-Initiated, Retrospective, Multicenter, Observational Study

Mean oocytes retrieved 13.4 ± 6.2 (r-FSH) versus 6.1 ± 7.6 (r-FSH+hMG); metaphase II oocytes 11.0 ± 5.4 versus 4.8 ± 6.3. Pain score 1.2 ± 1.3 for r-FSH, 3.6 ± 2.2 for hMG.

Obstetrics & Gynaecology · Cureus · 11 Sept

Safety and Recovery Profile of Propofol-Based Intravenous Sedation for Endoscopic Retrograde Cholangiopancreatography in Adults: A Prospective Single-Center Observational Study

No oxygen desaturation or intubation (0/100, 95% CI 0-3.6). Airway maneuvers and procedural interruption in 5/100 (5%), PONV in 4/100 (4%). Median recovery 5 minutes.

Anaesthesiology · Cureus · 11 Sept

Neurosurgical Outcomes of Epilepsy Surgery Between 2017 and 2025: A Retrospective ESSQ-19 Study From a Tertiary Care Center

ESSQ-19 summary score was 84.1±21.7. Surgical complication domain scored 89.2±21.1 and seizure control 85.0±27.6, while psychosocial domain scored lower at 79.9±24.1.

Neurology · Cureus · 11 Sept

GSK’s Hansoh-partnered ADC lays down marker for lung cancer scrap with Merck

A new ADC achieved 18.5-month median overall survival in phase 3 lung cancer, potentially adding a treatment option beyond current standard regimens.

Oncology · Fierce Biotech · 11 Sept

Preservation of Non-nidal Medial Veins During Microsurgical Resection of Cerebral Arteriovenous Malformations: Technical Considerations and Early Clinical Outcomes

Complete angiographic nidus eradication in all 16 patients, no perioperative mortality, and mRS 0-2 in 14 patients (87.5%). No delayed venous infarction or haemorrhagic transformation occurred.

Neurology · Cureus · 11 Sept

Early Prognostic Value of the Freiburg Index of Post-Transjugular Intrahepatic Portosystemic Shunt Survival in Patients With Hepatocellular Carcinoma Undergoing Liver Transplantation

Pre-transplant FIPS may flag HCC patients at higher risk of early post-transplant death, helping you refine waitlist and perioperative counselling.

Gastroenterology · Cureus · 11 Sept

A Structured, Auditable Taxonomy for Pharmacist-Identifiable Medication-Related Risk Signals in Routine Admission Data: A Retrospective Medication Safety Audit in a High-Risk Inpatient Cohort

Poor adherence 10 of 17; residual medication discrepancy 5 of 17; self-discontinuation 3 of 17; insulin instruction mismatch 2 of 17; suboptimal blood pressure control 9 of 13; suboptimal glycaemic control 5 of 8.

General Medicine · Cureus · 11 Sept

Reverse Total Shoulder Arthroplasty in a 25-Year-Old Woman With Seropositive Rheumatoid Arthritis After Prior Age-Based Surgical Deferral

At two years, ASES score 80/100 (pain 3/10, ADL 27/30) and SANE 95%, with no instability, infection, or mechanical failure.

Orthopaedics · Cureus · 11 Sept

Pediatric Headache: A Practical Approach to Clinical Diagnosis and Management

No numerical results reported. Diagnosis rests on structured history, disability assessment and examination; red flags prompt risk stratification rather than reflexive neuroimaging

Paediatrics · Cureus · 11 Sept

Mpox (Formerly Known as Monkeypox) in Dermatological Practice: Presentation of a Series of Four Clinical Cases at a Referral Hospital

Presentations ranged from disseminated vesiculopustular eruptions with systemic symptoms to strictly localised painful perianal lesions without prodrome; one case was initially misdiagnosed as herpes.

General Medicine · Cureus · 11 Sept

Unusual Vascular Claudication in a Seronegative Patient: Raynaud's Phenomenon or Atypical Buerger Disease

Proximal vessels were patent with sluggish distal forearm flow and diminutive radial and ulnar arteries at the wrist; hypercoagulable and vasculitis workup was unrevealing and inflammatory markers stayed normal.

General Medicine · Cureus · 11 Sept

Simultaneous derivation, validation, and comparison of predictor hazard ratios for cardiovascular risk prediction equations in patients with diabetes from high versus non-high income countries: cohort study.

Age hazard ratio per 10 years in women was 1.61 (1.51 to 1.71) in New Zealand versus 2.51 (2.32 to 2.72) in China. Recalibration alone left expected-to-observed ratios of 0.938 in men and 0.809 in women.

Cardiology · BMJ · 11 Sept

Joint impact of pathological burden and cognitive resilience on Alzheimer's disease risk.

Incident AD dementia: pathology hazard ratio 2.50 per s.d. (95% CI 2.30-2.72); resilience hazard ratio 0.51 per s.d. (95% CI 0.48-0.55). The two interacted multiplicatively.

Neurology · Nature Medicine · 11 Sept

Immunogenicity of fractional one-fifth and one-half doses of 17DD yellow fever vaccine compared with full dose in children aged 9-23 months in Uganda: a phase 4, single-blind, randomised clinical trial.

Both fractional doses met non-inferiority (5 percentage-point margin) for seroconversion at 4 weeks; one-half versus full dose difference was -0.17 (95% CI -0.52 to 0.17), with no difference between one-fifth and full doses.

Paediatrics · Lancet · 11 Sept

Teclistamab versus lenalidomide-dexamethasone in high-risk smoldering multiple myeloma: a randomized phase 2 trial.

Complete response 77.8% with teclistamab versus 0% with Rd; MRD negativity 82.2%. At median follow-up 24.5 months, 2-year progression-free survival 92% versus 49%.

Oncology · Nature Medicine · 11 Sept

MMSDH facilitates ACSL4 propionylation to counteract ferroptosis upon hypoxia and impairs PDAC chemotherapy efficacy.

Hypoxia-induced MMSDH lactylation at K113 promotes ACSL4 degradation via chaperone-mediated autophagy; MMSDH-mediated ACSL4 propionylation correlated with low ACSL4 and poor NAC response in recipients.

Oncology · Nature cancer · 11 Sept

Oral Health in Hospitalized Adults: Clinical Outcomes and the Role of Dental Expertise

Strongest evidence is for respiratory outcomes; recent randomised evidence gives preliminary support for structured multicomponent oral care reducing non-ventilator hospital-acquired pneumonia on general wards. Chlorhexidine evidence remains inconsistent.

General Medicine · Cureus · 11 Sept

Disseminated Pulmonary Coccidioidomycosis Presenting as a Wedge-Shaped Necrotic Mass Mimicking Malignancy

CT showed a 7.3 × 5.4 cm wedge-shaped necrotic right middle lobe mass with bilateral nodules; biopsy showed granulomatous inflammation with fungal elements, confirmed by serology and BAL PCR

General Medicine · Cureus · 11 Sept

Rapid Resolution of Apophenic Psychosis With Low-Dose Olanzapine in Very Late-Onset Schizophrenia-Like Psychosis

Limited response to quetiapine; rapid and sustained remission on low-dose olanzapine, with symptom recurrence after dose reduction supporting a primary psychotic process

Psychiatry · Cureus · 11 Sept

Comparative Evaluation of Concurrent Carboplatin-Paclitaxel Versus Cisplatin-Etoposide Chemoradiotherapy in Unresectable Non-small Cell Lung Cancer: A Prospective Randomized Study

Tumour-response distribution favoured EP (p=0.029). 12-month PFS 40.0% EP versus 25.0% PC (p=0.206); 12-month OS 80.0% versus 56.3% (p=0.144). EP caused more severe anemia, thrombocytopenia and esophagitis.

Oncology · Cureus · 11 Sept

Factors Influencing Adherence to Mammography Screening Guidelines Among Women From Diverse Cultural Backgrounds: A Systematic Review

Higher adherence was associated with higher educational level, health insurance coverage, older age, and advice by a healthcare professional. Barriers included screening costs, lack of insurance, communication difficulties, cultural and fatalistic beliefs, fear and embarrassment.

Obstetrics & Gynaecology · Cureus · 11 Sept

Right Coronary Artery Thrombosis Causing ST-Elevation Myocardial Infarction After a Coronary Artery Disease Reporting and Data System Score of 0, With Disseminated Intravascular Coagulation During Idiopathic Acute Pancreatitis: A Case Report

A 99% thrombotic subtotal occlusion of the mid-right coronary artery caused inferior STEMI; coronary CT angiography five months earlier had shown an Agatston score of 0 and CAD-RADS 0.

Cardiology · Cureus · 10 Sept

Mass Effect Score Associations in Comatose Trauma Patients With Intracranial Hemorrhage Requiring Mechanical Ventilation: A Retrospective Study

Mortality and adverse outcomes were associated with MES ≥2 (both p 0.05). Failure to follow commands at three months was also associated with MES ≥2 (p 0.05).

Neurology · Cureus · 10 Sept

Weekly Rundown: Cleveland Clinic taps Luminai for AI automation; Quest brings lab testing to Apple Health

US health systems are embedding AI into scheduling and lab-result delivery; expect similar vendor pitches to reach Indian hospitals and clinics within months.

Medicine · Fierce Healthcare · 10 Sept

When Speech Signals Wilson Disease: A Case Report

Kayser-Fleischer rings, reduced serum ceruloplasmin, elevated 24-hour urinary copper, decompensated liver disease, and MRI signal changes in basal ganglia, thalami, and periventricular white matter confirmed Wilson disease; D-penicillamine and zinc led to clinical improvement

Neurology · Cureus · 10 Sept

STAT+: Can AI save rural health care?

Federal bets on AI for rural care may shape what tools reach your understaffed district hospital, though none are proven yet.

General Medicine · STAT News — Health Tech · 10 Sept

Graph AI raises $13.3 Mn in Series A round led by Insight Partners

Company claims live deployments reduced adverse event case processing turnaround from more than three hours to under 10 minutes, a reduction of over 90%, and lowered operating costs by up to 66%

Medicine · Entrackr · 10 Sept

Clinical and Radiographic Success of Pulpotomy in Permanent Teeth With Irreversible Pulpitis: A Systematic Review

Across 16 included studies, pulpotomy consistently gave favourable clinical and radiographic success in permanent teeth with irreversible pulpitis, especially with MTA, Biodentine, CEM and other bioceramics.

General Medicine · Cureus · 10 Sept