Archive

Suspected Seronegative Spondyloarthropathy in a Young Woman With Ulcerative Colitis and Concurrent Bleeding Symptoms

In UC patients with new joint pain, consider HLA-B27-negative spondyloarthropathy even without sacroiliitis, and screen for concurrent bleeding before starting NSAIDs.

Gastroenterology · Cureus · 14 Sept

Anatomic Reconstruction of Acute Posterior Shoulder Instability With Reverse Hill-Sachs Lesions: A Report of Two Cases

At 24 months neither patient had recurrent instability or reoperation. Forward elevation 160° in both; ASES scores 90 and 88; SANE 95 and 93; pain 0 of 10 in both.

Orthopaedics · Cureus · 14 Sept

Pneumococcal population structure influences the effects of air pollution on invasive disease risk in South Africa.

Air pollution raises invasive pneumococcal disease risk unevenly across serotypes, so vaccinating high-risk patients matters more on bad-air days.

General Medicine · Nature microbiology · 14 Sept

Circulating tumor DNA-guided de-escalation or escalation of adjuvant therapy in high-risk stage II and stage III colon cancer: the phase 2 PEGASUS trial.

The 2-year relapse-free rate among ctDNA-negative patients was 88% (90% CI 81-93%), below the predefined 92% threshold; the primary endpoint was not met. ctDNA-positive patients had a 3-year disease-free survival of 58% versus 83% (HR 2.71; 95% CI 1.35-5.45; P=0.0036).

Oncology · Nature cancer · 14 Sept

Adoption of Adjunctive Azithromycin for Unscheduled Cesarean Delivery and Postpartum Infections.

Azithromycin use at cesarean rose from 2.2% to 39.6% (adjusted difference-in-differences 37.6 percentage points, 95% CI 33.1 to 42.2); postpartum infection fell 2.0 percentage points (95% CI -2.6 to -1.4).

Obstetrics & Gynaecology · JAMA · 14 Sept

Idiopathic Normal Pressure Hydrocephalus: A Review.

Gait disturbance occurs in 85%-95%, urinary dysfunction in 75%-90%, cognitive impairment in 60%-80%. After shunting, gait velocity improves in 75%-80%, cognition and urinary symptoms in 50%-70%.

Neurology · JAMA · 14 Sept

Surgical Technique – The “Derriere View” for Evaluation of Guidewire Position in Cephalomedullary Nailing of Intertrochanteric Femur Fractures

An added intraoperative fluoroscopic view may catch malpositioned guidewires before reaming, reducing cut-out in elderly IT fracture nailing.

Orthopaedics · Cureus · 14 Sept

Abridge expands into revenue cycle with AI-powered pre-bill claim review

If your hospital adopts this, AI will flag documentation gaps before claims go out, shifting CDI queries from coders to your notes.

Medicine · Fierce Healthcare · 14 Sept

Ischemic Stroke During Rivaroxaban Therapy: The Importance of Food-Dependent Absorption and Careful Assessment Before Antithrombotic Escalation

Before adding an antiplatelet after a stroke on rivaroxaban, check food-dependent absorption and timing — escalation may raise bleeding without fixing the cause.

Cardiology · Cureus · 14 Sept

Transient Post-infectious Multisystem Inflammatory Overlap Presentation in a Pediatric Patient With Neurological, Hepatic, Gastrointestinal, and Autoimmune Manifestations: A Rare Case From Azerbaijan

Transient autoantibody positivity and incidental neuroinflammatory imaging changes, hepatic steatosis and gastrointestinal inflammation appeared disproportionate to clinical status and resolved without immunosuppression or invasive intervention

Paediatrics · Cureus · 13 Sept

Transfascial Paraspinal Versus Conventional Open Posterior Pedicle Screw Fixation for Thoracolumbar Fractures: A Randomized Controlled Trial

Transfascial group had less blood loss (173.76±37.94 vs 294.00±89.35 mL, p<0.001), lower drain output (37.60±18.94 vs 93.20±43.48 mL, p<0.001), shorter stay (3.08±1.82 vs 5.48±4.30 days, p=0.012); Cobb correction similar (4.40±1.15° vs 4.60±1.19°, p=0.549).

Orthopaedics · Cureus · 13 Sept

When Fever Hides Fire: A Systematic Review of Clinical and Digital Approaches to Early Recognition of Pediatric Sepsis

Approaches performed well ruling out sepsis in low-risk children, but case detection and alert burden varied by thresholds, settings, and sepsis definitions; no approach was consistently superior

Paediatrics · Cureus · 13 Sept

Comparative Outcomes of Transoral Robotic Surgery Versus Open Surgery in Head and Neck Cancer: A Systematic Review and Meta-Analysis

TORS was associated with lower tracheostomy rates, shorter hospital stay, and reduced feeding tube dependence; recurrence and overall survival favoured TORS; complications and positive margins were comparable.

Oncology · Cureus · 13 Sept

Integrated Clinical, Biological, and Echocardiographic Factors Independently Associated With In-Hospital Mortality in Infective Endocarditis: A Single-Centre Cohort Study From Morocco

In-hospital mortality was 27.7% (72/260). Independent predictors: septic shock (aOR 28.45; 95% CI 3.42-106.80), vegetation >15 mm (aOR 2.50; 95% CI 1.00-6.20), male sex (aOR 2.68; 95% CI 1.12-6.42), anaemia and severe renal dysfunction.

Cardiology · Cureus · 13 Sept

Cytomegalovirus Retinitis Mimicking Acute Retinal Necrosis During Upadacitinib Therapy

Aqueous humor PCR detected CMV DNA at 6.85 × 10⁴ copies/mL; HSV and VZV were negative, HIV RNA undetectable, and peripheral-blood CMV antigenemia negative. Vision remained poor despite treatment.

Ophthalmology · Cureus · 13 Sept

Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLC.

An explainable AI tool trained on 2,396 real-world NSCLC cases may sharpen immunotherapy selection beyond PD-L1 alone, but awaits validation before replacing current scoring.

Oncology · Nature Medicine · 13 Sept

Most-favoured-nation pricing for prescription drugs in US Medicare: a cohort study.

US Medicare MFN rebates could reset global reference prices, indirectly squeezing Indian drug supply and pricing for the medicines you prescribe.

General Medicine · Lancet · 13 Sept

Alternative Medicine and Nutritional Therapy in Adult Inflammatory Bowel Disease in India: A Move Towards Holistic Practice

No primary outcome or effect size reported. Curcumin is described as a safe, feasible adjunct in ulcerative colitis; exclusive enteral nutrition shows promise in Crohn's disease but is not standard practice.

Gastroenterology · Cureus · 13 Sept

Beat-to-Beat Nystagmus Differentiation Between Benign Paroxysmal Positional Vertigo (BPPV) and Vestibular Migraine (VM): A Cross-Sectional Videonystagmographic Study From Northern India

Peak nystagmus amplitude and slow-phase velocity were higher in BPPV (mean peak amplitude 11.55° vs 5.64°, p=0.02; mean peak SPV 21.16°/s vs 13.10°/s, p=0.005).

Neurology · Cureus · 13 Sept

When the Cure Turns Into a Culprit: Mesalamine and the Eosinophilic Lung

In UC patients on mesalamine who develop cough, fever or dyspnea, consider drug-induced eosinophilic lung disease and stop the drug rather than escalating therapy.

Gastroenterology · Cureus · 12 Sept

Hypothyroidism Versus Hyperthyroidism in Patients With Abnormal Uterine Bleeding: An Observational Study

Hypothyroidism in 33 (13.1%), hyperthyroidism in 8 (3.2%). Irregular menstruation in 6 (75.0%) hyperthyroid versus 9 (27.3%) hypothyroid, p=0.012; menorrhagia in 18 (54.5%) hypothyroid versus 2 (25.0%) hyperthyroid.

Obstetrics & Gynaecology · Cureus · 12 Sept

Quantifying Diagnostic Misclassification and Inpatient Mortality Determinants in Scrub Typhus: A Systematic Review and Interaction Meta-Analysis of Acute Undifferentiated Febrile Illness (AUFI) Cohorts in India

Pooled scrub typhus prevalence 14.60% (95% CI 11.27-18.71); high-rigor assays 17.40% versus rapid ICT or Weil-Felix 11.90% (p = 0.024); pooled inpatient mortality 4.92% (95% CI 2.98-7.95)

General Medicine · Cureus · 12 Sept

Maternal Delivery Outcomes Associated With Acute Sickle Cell Crisis: A National Inpatient Analysis

Severe preeclampsia, eclampsia or HELLP occurred in 27.9% with crisis versus 6.8% without (adjusted OR 4.63; 95% CI 2.43-8.85). Cesarean delivery adjusted OR 2.18 (95% CI 1.30-3.68).

Obstetrics & Gynaecology · Cureus · 12 Sept

Music in the Operating Room: Impact on Team Communication, Focus, and Monitoring Patient Safety

70.3% (n=97) reported mood benefits, but 33% (n=37) impaired communication, 8% (n=11) impaired concentration and 11.6% (n=16) impaired safety monitoring; 66.2% (n=49) said appropriateness varied by surgical phase.

Anaesthesiology · Cureus · 12 Sept

Granulomatous Interstitial Nephritis Associated With Adalimumab Therapy in a Patient With Rheumatoid Arthritis: A Case Report

Renal biopsy showed granulomatous interstitial nephritis. Adalimumab was stopped and steroids started; kidney function improved.

General Medicine · Cureus · 12 Sept

Recurrent Great Saphenous Vein Reflux After Prior Endovenous Laser Therapy: Diagnostic and Management Challenges in Chronic Venous Insufficiency

Duplex ultrasound showed near-continuous reflux in the proximal GSV with incompetent accessory and perforator veins, indicating recurrence driven by untreated tributaries rather than the ablated segment alone.

General Surgery · Cureus · 12 Sept

Shared Decision-Making and Decision Support in Advanced Chronic Kidney Disease: A Systematic Review of Models, Treatment Pathways, and Patient-Centered Outcomes

Structured decision aids for dialysis-versus-conservative-care choices may improve modality selection and patient-reported outcomes; this review maps which models have evidence behind them.

General Medicine · Cureus · 12 Sept

Racial and Ethnic Disparities in Receipt of Behavioral Treatment Among Children With Autism Spectrum Disorder in the United States

564 of 790 (71.4%) received behavioural treatment. Non-Hispanic Black children were less likely than White children to receive it (adjusted OR 0.47, 95% CI 0.28-0.79). Asian, Hispanic and multiracial differences were not significant.

Paediatrics · Cureus · 12 Sept

India crosses 80 lakh HPV vax in nationwide cervical cancer prevention drive

With 80 lakh girls aged 14 now vaccinated, HPV coverage is becoming routine in India — expect more questions from parents and fewer missed opportunities to offer the vaccine.

Obstetrics & Gynaecology · ETHealthworld · 12 Sept

Efficacy and safety of mitapivat in adults with transfusion-dependent α-thalassaemia or β-thalassaemia (ENERGIZE-T): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial.

Transfusion reduction response occurred in 52 (30%) of 171 on mitapivat versus 11 (13%) of 87 on placebo; adjusted difference 18 percentage points (95% CI 8-27; p=0·0003).

General Medicine · Lancet · 12 Sept

Tambotatug Pelitecan in Small-Cell Lung Cancer after Platinum-Based Therapy.

Median overall survival 13.3 vs 9.4 months (HR 0.46, 95% CI 0.35-0.62; P<0.001). Median progression-free survival 7.4 vs 2.8 months. Objective response 59.1% vs 9.7%. Grade 3+ adverse events 55.4% vs 77.9%.

Oncology · NEJM · 12 Sept

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Based Genome Editing in Inherited Cardiovascular Diseases: Therapeutic Advances, Emerging Editing Platforms, and Translational Challenges

No trial results are reported. Preclinical work corrected MYBPC3 and MYH7 in HCM, targeted TTN, RBM20 and LMNA in DCM, restored ion channel function, and modulated PCSK9, LDLR and ANGPTL3.

Cardiology · Cureus · 12 Sept

Systematic Review and Meta-Analysis on Central and/or Peripheral Nervous System Demyelination in Patients Treated With Tumor Necrosis Factor Alpha (TNF-α) Inhibitors

Pooled random-effects estimates: RR 1.46 (95% CI 1.09-1.95) for CNS demyelination and RR 2.00 (95% CI 1.19-3.38) for PNS demyelination.

Neurology · Cureus · 11 Sept

Cardiac Metastasis From Lung Cancer: A Hidden Cardioembolic Source of Acute Ischemic Stroke

Brain MRI showed multiple acute ischemic infarcts in the left middle cerebral artery territory; cardiac imaging found a left ventricular mass suggestive of metastasis. She died one year later.

Neurology · Cureus · 11 Sept

Benchmarking Drug Library Compliance and Alert Rates in Smart Infusion Pumps: A Multicenter Retrospective Study

Overall DL compliance was 95.9%, mean alert rate 33.3% (±12.20), override rate 96.4%, and one good catch per 34.5 DERS infusions. No significant differences between compliance groups.

Anaesthesiology · Cureus · 11 Sept

Jugular Venous Compression via Soft Cervical Collar in Shunt-Refractory Low-Pressure Hydrocephalus: A Report of Two Cases

Third ventricular width decreased from 13 to 8 mm in case 1 and 13 to 4 mm in case 2; ventriculomegaly recurred on collar cessation and resolved on reapplication in case 1

Neurology · Cureus · 11 Sept

Definium LSD drug goes 3 for 3 with another pivotal anxiety trial win

A third positive phase 3 supports LSD-assisted therapy as a regulated option for anxiety, though psychedelic protocols need supervised dosing and monitoring your clinic may not have.

Psychiatry · Fierce Biotech · 11 Sept

Polyvascular Atherosclerotic Disease: A Narrative Review of the Role of Systematic Bedside Vascular Examination

No original data or effect estimates are reported; the review argues that abnormal bedside findings should prompt selective ABI, duplex, CTA, MRA or cardiac testing rather than indiscriminate imaging.

Cardiology · Cureus · 11 Sept

Cullinan, Taiho showcase 6-month survival benefit in phase 3 trial for advanced lung cancer

A six-month frontline survival gain in advanced NSCLC offers your EGFR-mutant patients a new first-line option beyond current standard combinations.

Oncology · Fierce Biotech · 11 Sept

Owkin, Servier ink oncology R&D deal to guide discovery and trial design

AI-guided trial design could sharpen oncology trial enrolment and biomarker selection, but no clinical data yet shows it improves patient outcomes.

Oncology · Fierce Biotech · 11 Sept