Archive

5-year outcomes of chemotherapy de-escalation in HER2-positive early breast cancer and exploratory circulating tumor DNA analyses from the randomized phase 2 PHERGain trial.

Confirms that PET-response-guided omission of chemotherapy preserves 5-year outcomes in HER2-positive early breast cancer, supporting de-escalation in selected patients.

Oncology · Nature Medicine · 7d

A clinical multimodal vision language foundation model with fine-grain explainability.

A multimodal model that shows its reasoning could make AI imaging and text tools auditable enough to trust at the point of care.

General Medicine · Nature Medicine · 7d

A genome‑wide screen in E. coli reveals metabolic adaptations that enhance intratumoral fitness and bacterial cancer therapy efficacy.

Deleting nonglucose phosphotransferase systems improved tumour colonisation in E. coli — a design rule for the bacterial cancer therapies now entering early-phase trials.

Oncology · Nature cancer · 7d

Insights into early-onset colorectal cancer from a single-nucleus RNA-seq atlas of colorectal cancer across the age continuum.

Early-onset CRC appears biologically distinct at the single-cell level, which may eventually justify different treatment or surveillance for patients diagnosed under 50.

Oncology · Nature Medicine · 7d

Temporal proteomics maps concealed-stage remodeling and reveals early mitochondrial alteration as an intervention target in a model of PKP2-arrhythmogenic cardiomyopathy.

In PKP2 mutation carriers, mitochondrial changes appear before any structural disease — a possible window for early intervention, though only in mice so far.

Cardiology · Nature cardiovascular research · 7d

Gram-negative resistance spreads via mobile genetic elements and reduced drug entry

No primary data or effect estimates are reported. Resistance arises through reduced drug entry, efflux, target modification and enzymatic inactivation, most notably β-lactamase production, with mobile genetic elements accelerating dissemination of resistance genes.

General Medicine · NEJM · 7d

From Variation to Standardisation: An Electronic Health Record Intervention to Improve Risk Stratification and Admission Decisions in Acute Lower Gastrointestinal Bleeding

Embedding the Oakland score in the EHR cut unstructured admission decisions for acute LGIB — a validated discharge tool your surgical take can adopt rather than eyeball.

Gastroenterology · Cureus · 8d

Oura, UC San Diego Health collaborate to study GLP-1 outcomes using continuous smart ring data

If ring-derived sleep and activity data predict GLP-1 response, you may soon titrate obesity therapy using objective adherence and physiological signals rather than weight alone.

Endocrinology · Fierce Healthcare · 8d

Parvovirus B19-Associated Meningoencephalitis in an Adult: A Rare Cause of Central Nervous System Infection

Consider B19V in adults with headache, photophobia and diplopia plus non-specific CSF; a positive CSF PCR is hard to interpret, so pair it with serology before committing.

Neurology · Cureus · 8d

Microbiological Profile and Antimicrobial Susceptibility Patterns of Non-fermenting Gram-Negative Bacilli Isolated From Clinical Specimens in a Tertiary Care Hospital: A Prospective Study

P. aeruginosa susceptibility peaked at amikacin 50.00%, cefepime 46.49%, meropenem 45.61%. A. baumannii: minocycline 35.90%, imipenem and meropenem 10.26% each. B. cepacia complex meropenem 75.00%; S. maltophilia minocycline 86.67%.

General Medicine · Cureus · 8d

Heterotopic Triplet Pregnancy: A Case Report

An intrauterine sac does not exclude a coexisting ectopic, especially after ovulation induction — scan the adnexa before discharging early pregnancy pain.

Obstetrics & Gynaecology · Cureus · 8d

Impact of Perioperative Glycemic Variability on Surgical Outcomes in Patients With and Without Diabetes: A Multicenter Prospective Observational Study

Repeated perioperative glucose swings, not just a single high reading, track with postoperative morbidity in both diabetic and non-diabetic surgical patients — so serial monitoring may be worth the effort.

Anaesthesiology · Cureus · 8d

Anesthetic Management for Elective Cesarean Section in a Pregnant Woman With Hypertrophic Obstructive Cardiomyopathy and a Marked Family History: A Case Report Focusing on Efficient Hemostasis Using Fibrinogen Concentrate

In HOCM parturients, spinal-epidural with norepinephrine infusion plus fibrinogen concentrate controlled hemodynamics and bleeding—a usable template when neuraxial anesthesia risks outflow obstruction.

Anaesthesiology · Cureus · 8d

Meropenem-Induced Thrombocytosis: A Case Report

If platelets spike on day 7 of meropenem while the patient is clinically improving, consider a drug effect rather than worsening infection before changing antibiotics.

General Medicine · Cureus · 8d

STAT+: Why every health care AI company must face Epic

Epic's grip on hospital records shapes which AI tools reach your ward, so vendor lock-in may limit the clinical software you are offered.

General Medicine · STAT News — Health Tech · 8d

New York officials share OUD treatment progress, plans for new pilot to treat stimulant use disorder

Take-home methadone and buprenorphine flexibility is now policy reality; expect similar deregulation pressure and stimulant-use pilots to shape Indian addiction services.

Psychiatry · Fierce Healthcare · 8d

On-Pump Coronary Artery Bypass Grafting With Concomitant Transaortic Left Ventricular Thrombectomy in a Patient With Severe Ischemic Cardiomyopathy and Viable Myocardium: A Case Report

When a mobile LV thrombus coexists with triple-vessel disease, waiting 4-8 weeks for anticoagulation may cost myocardium; combined transaortic thrombectomy at CABG is a feasible single-stage option.

Cardiology · Cureus · 8d

Multifocal Disseminated Tuberculosis Involving the Lung, Hilar Lymph Node, Femur, and Thigh in an Immunocompetent 14-Month-Old Child

In an endemic setting, a toddler with lung and bone lesions can have disseminated TB despite normal immunity — consider it before assuming malignancy or pyogenic infection.

Paediatrics · Cureus · 8d

A Rare and Risky Implantation: Cervical Ectopic Pregnancy Following Recent Surgical Management of Miscarriage

After surgical miscarriage management, consider cervical ectopic in any woman with cramping or bleeding — it can haemorrhage catastrophically, and prior cervical surgery raises the risk.

Obstetrics & Gynaecology · Cureus · 8d

Infantile Meningitis Due to Multidrug-Resistant Acinetobacter Baumannii: A Case Report Highlighting Treatment Challenges

MDR Acinetobacter neonatal meningitis leaves few antibiotic options; suspect it early in healthcare-associated sepsis and involve microbiology before empirical escalation fails.

Paediatrics · Cureus · 8d

Scalp Swelling Caused by Extracranial Extension of Meningioma

A scalp lump with new neurological symptoms warrants imaging — this case shows meningioma can erode calvarium and present extracranially, so don't dismiss it as benign.

Neurology · Cureus · 8d

Perianal Abscesses During Tirzepatide Treatment: A Report of Two Cases

If a patient on tirzepatide presents with anorectal pain, consider perianal abscess rather than constipation alone; two cases suggest a possible link worth asking about.

General Surgery · Cureus · 8d

Etranacogene Dezaparvovec: 15-Month Follow-Up of the First Patient Infused in Spain

Real-world 15-month data on AAV gene therapy for haemophilia B, including late liver events, informs monitoring after a one-time infusion that may replace prophylaxis.

General Medicine · Cureus · 8d

Reversibility of Antipsychotic-Induced Dyslipidaemia: A Narrative Review of Switching Strategies, Dose Reduction and Discontinuation

Before adding a statin, consider that switching or reducing the antipsychotic may itself improve lipids — this review maps which strategies have evidence.

Psychiatry · Cureus · 8d

New national air pollution standards wait as review drags on for 5 yrs

India's 2009 PM2.5 limits are far looser than WHO's; five more years of delay means your patients keep breathing air judged unsafe by current evidence.

General Medicine · ETHealthworld · 8d

Spinal Teratoma in an Adult Female Patient: A Case Report

Rare intramedullary teratomas mimic common radiculopathy; keep them on the differential when a young adult has progressive bilateral leg symptoms and nonspecific back pain.

Neurology · Cureus · 8d

Contemporary Hard Tissue Management of Peri-Implantitis

Peri-implant bone loss is progressive and often silent; knowing when grafting or resection beats debridement alone changes how early you refer implant patients.

Medicine · Cureus · 8d

Advertising Standards Council flags misleading claims in nutraceutical ads

Patients bring these ads to your OPD expecting time-bound cures; knowing the ASCI has flagged them lets you counter claims about supplements rather than argue from scratch.

General Medicine · ETHealthworld · 8d

Application of Functional Alignment Principles and Stepwise Gap Balancing in Staged Bilateral Total Knee Arthroplasty for Severe Varus Knee Osteoarthritis With Lateral Femoral Bowing Using Conventional Instrumentation: A Case Report

Shows functional alignment and stepwise gap balancing can be done with conventional instrumentation in severely varus, bowed femora, so you need not defer these knees for robotic or navigation setups.

Orthopaedics · Cureus · 8d

Indications and Complications of Tunnelled Haemodialysis Catheters: A Single-Centre Retrospective Study of 114 Patients

Tunnelled catheters remain a bridge to AVF; knowing the dominant complication and transition rates helps you counsel dialysis patients and time access referral.

General Surgery · Cureus · 8d

STAT+: As Epic’s dominance grows, its iron grip is choking innovation in health technology

If your hospital runs Epic, third-party tools that read your patient data may be blocked at the vendor's discretion, limiting what you can deploy at the bedside.

General Medicine · STAT News — Health Tech · 8d

Adalimumab-Associated Thyroiditis in a Patient With Pre-existing Hypothyroidism: A Case Report and Literature Review

Meningitis was excluded on CSF analysis and neuroimaging; thyroid imaging showed thyroiditis with reactive lymphadenopathy, anti-TPO antibodies were elevated, and thyroid hormone levels stayed within the reference range. Corticosteroids gave significant symptomatic improvement.

Endocrinology · Cureus · 8d

Accuracy of Provisional Reports by Radiology Residents on Call

Overall discrepancy rate 144 of 993 (14.5%); major and significant discrepancies 56 of 993 (5.6%). Rates differed by specialty: body 21.6%, MSK 17.2%, neuro 11.7%, vascular 5.4% (p < 0.001). No association with resident grade (p = 0.48) or reporting hour (p = 0.37).

Radiology · Cureus · 8d

An Audit of the Management of Neonatal Jaundice in a Level 2 Neonatology Unit of a Maternity Hospital Against the 2023 NICE Guidelines

Overall NICE adherence was 54.3% (25/46) against a 100% standard. Visual jaundice was present in 91.3% (42/46) but only 21.7% (10/46) had bilirubin levels requiring phototherapy.

Paediatrics · Cureus · 8d

Clinician-Reported Consequences and Patient Outcomes in Disputed Emergency Department Admission Referrals: A Systematic Review

Only one study reported outcomes for patients with a disputed referral: of 109 rejected admission requests, 97 (89.0%) were eventually admitted and 66 (60.6%) under the first team contacted; ED length of stay rose with teams involved.

General Medicine · Cureus · 8d

Association Between Early-Onset Atopic Dermatitis and Risk of Asthma in Individuals With a Family History of Atopy: A Systematic Review

In infants with family atopy, early eczema marks raised asthma risk — ask about family history and counsel parents on watching for wheeze.

Paediatrics · Cureus · 8d

Phenotypic Detection of Metallo-β-Lactamase Production and Antimicrobial Susceptibility Patterns Among Multidrug-Resistant Klebsiella spp. Isolated From Intensive Care Units: A Prospective Observational Study

If your ICU's Klebsiella are MBL-producers, carbapenems are already failing — local susceptibility data should steer empiric choice before culture results return.

General Medicine · Cureus · 8d

Hemifacial Spasm After Ultrasound-Guided Left Stellate Ganglion Block for Post-traumatic Stress Disorder (PTSD): A Case Report

A rare but real complication of an increasingly used PTSD block: counsel patients on facial spasm and know it can follow an uncomplicated C7-level injection.

Anaesthesiology · Cureus · 8d

Clinical Outcomes Following Intravenous Saline Infusion in Adolescents With Refractory Postural Orthostatic Tachycardia Syndrome: A Retrospective Study

Retrospective data on whether IV saline during flares actually improves function in refractory adolescent POTS, and what adverse events to expect before you commit a teenager to repeated infusions.

Paediatrics · Cureus · 8d

Percutaneous Cholangioplasty for Benign Biliary Strictures: Long-Term Follow-Up With Review of Technical Factors Predicting Success

For benign biliary strictures unsuitable for surgery, this identifies which dilation techniques predict durable patency, helping you plan reintervention intervals and set patient expectations.

Radiology · Cureus · 8d