Archive

Microwave Ablation Versus Radiofrequency Ablation for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

Initial complete ablation was similar (28 studies, 6,036 participants; RR 1.01, 95% CI 1.00-1.02). MWA reduced local tumour progression (27 studies, 5,166 participants; RR 0.67, 95% CI 0.54-0.83), consistent in randomised trials (RR 0.55, 95% CI 0.40-0.76).

Oncology · Cureus · 28 Sept

Carbohydrate Quality Versus Quantity in Gestational Diabetes Mellitus While Considering Randomized Dietary Interventions: A Systematic Review

When counselling GDM patients on diet, prioritising low-glycaemic-index carbohydrates over strict carb counting may be the more defensible first-line advice.

Obstetrics & Gynaecology · Cureus · 28 Sept

Atypical Presentation of a Meningioma Masquerading as Trigeminal Neuralgia: A Diagnostic Challenge in the Emergency Department

Atypical features (prolonged sensory loss, proptosis, diplopia) prompted imaging; CT showed a sclerotic sphenoid lesion, MRI revealed a large en plaque meningioma with orbital extension and optic nerve compression, plus a separate right cerebellopontine angle meningioma.

Neurology · Cureus · 28 Sept

Complement Factor H Mutation-Associated Atypical Haemolytic Uraemic Syndrome Presenting With Dialysis-Dependent Renal Failure: A Case Report

Renal biopsy showed thrombotic microangiopathy; genetic testing found a pathogenic complement factor H splice site mutation. He required urgent dialysis and remains dialysis dependent after declining eculizumab

Urology · Cureus · 28 Sept

Reproductive and Gynecologic Effects of Glucagon-Like Peptide-1 Receptor Agonists in Women With Polycystic Ovary Syndrome: A Scoping Review

Before prescribing GLP-1 agonists to PCOS patients for weight loss, know the evidence on menstrual regularity, ovulation and fertility is still only scoping-level.

Obstetrics & Gynaecology · Cureus · 28 Sept

Laparoscopic and Robot-Assisted Surgery for Gestational Trophoblastic Disease: A Scoping Review of Patient Selection and Intraoperative Precautions

Guidelines cover when to operate for GTD but not the route; this maps selection criteria and intraoperative precautions for laparoscopic or robotic hysterectomy.

Obstetrics & Gynaecology · Cureus · 28 Sept

Association of Serum Magnesium Concentration With Microvascular Complications Among Patients Diagnosed With Type 2 Diabetes Mellitus: An Observational Cross-Sectional Analysis

Low serum magnesium tracked with retinopathy, nephropathy and neuropathy in T2DM patients; consider checking magnesium in poorly controlled diabetes rather than ignoring it.

Endocrinology · Cureus · 28 Sept

Reverse Takotsubo Cardiomyopathy Complicated by Neurogenic Pulmonary Edema in Aneurysmal Subarachnoid Hemorrhage: A Case Report

In aSAH, basal hypokinesis with apical sparing plus neurogenic pulmonary edema can mimic acute MI; recognise it to avoid inappropriate thrombolysis or angiography.

Cardiology · Cureus · 28 Sept

Benefit and Harm in the Early Management of Suspected Cervical Spine Injury: A Narrative Review

Rigid collars, sequential imaging and steroids in suspected cervical injury are largely reflexive; this review weighs the evidence for each, so you can drop what harms.

Orthopaedics · Cureus · 28 Sept

Diagnostic Challenges of Regional Cardiac Tamponade in a Severely Volume-Overloaded Dialysis Patient: The Role of Multimodality Imaging

In dialysis patients with unexplained tachycardia, regional tamponade can hide without classic echo signs; multimodality imaging is needed before attributing it to volume overload.

Cardiology · Cureus · 28 Sept

Multidisciplinary Antimicrobial Stewardship Program in an Indian ICU: A Time-Series Analysis of Diagnostic Practices and Antibiotic Use

A multidisciplinary AMSP in an Indian ICU changed diagnostic and prescribing practice, giving you a locally tested model to cut unnecessary antibiotic use in your own unit.

General Medicine · Cureus · 28 Sept

Govt, private hospitals likely to be graded on quality & safety

Publicly benchmarked hospital grades would let you and your patients compare safety and outcomes across government and private facilities before referral.

Medicine · ETHealthworld · 28 Sept

Bone Marrow Aplasia Under Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia: A Rare and Unpredictable Complication

Rare but severe cytopenias can appear months into imatinib or nilotinib, so check marrow, not just counts, when a stable CML patient drops.

Oncology · Cureus · 28 Sept

Temporal Trends and Demographic Contributions to Stroke Burden in India, 1990–2023: An Analysis of Global Burden of Disease 2023 Estimates Using Shapley Decomposition and Joinpoint Regression

Incident cases rose from 0.73 million to 1.87 million (155.1%), deaths from 0.42 million to 1.03 million (148.2%), DALYs from 12.41 million to 25.99 million (109.4%). Age-standardised incidence stable; mortality and DALY rates declined.

Neurology · Cureus · 28 Sept

Prevalence and Clinical Characteristics of Myocardial Infarction With Non-obstructive Coronary Arteries Compared With Obstructive Myocardial Infarction: A Retrospective Tertiary-Centre Study

MINOCA was 2.9% of MIs. MINOCA patients were younger (52.1 vs 59.8 years; p=0.005) and more often presented as NSTEMI (51.4% vs 13.9%; p<0.001).

Cardiology · Cureus · 28 Sept

A Prospective Comparative Study of Opioid-Free Anesthesia and Opioid-Based Anesthesia for Postoperative Pain Relief in Patients Undergoing Laparoscopic Surgeries: A Double-Blinded Randomized Controlled Trial

Opioid-free anesthesia in laparoscopic surgery may cut PONV and respiratory depression while matching postoperative analgesia, so consider it for patients at risk of opioid side effects.

Anaesthesiology · Cureus · 28 Sept

Association Between Time-Weighted Haemoglobin A1c and Longitudinal Changes in Growth Parameters Among Children With Type 1 Diabetes: A Retrospective Cohort Study

Each unit rise in time-weighted HbA1c was associated with a fall in height-for-age z-score (beta -0.15, 95% CI -0.26 to -0.04). Effect was larger with diabetes duration over 5 years (beta -0.22) and baseline HbA1c over 9% (beta -0.28).

Paediatrics · Cureus · 28 Sept

Comparative Analysis of Vonoprazan- and Dexlansoprazole-Based Therapies for Helicobacter pylori Eradication: A Single-Center Retrospective Observational Study

Eradication was 93.15% (95% CI 84.95-97.04) with vonoprazan versus 83.56% (95% CI 73.43-90.34) with dexlansoprazole; the difference did not reach significance (p = 0.07).

Gastroenterology · Cureus · 28 Sept

Study of Ocular Fundus Changes in Pregnancy-Induced Hypertension and Visual Outcomes After Delivery

Fundus changes in PIH often regress after delivery, so retinal assessment can guide counselling and identify the few women needing postpartum ophthalmology follow-up.

Obstetrics & Gynaecology · Cureus · 28 Sept

Factors Associated With Recurrence in Patients With Benign Paroxysmal Positional Vertigo Following Canal Repositioning Therapy

Recurrence after repositioning is common, so identifying which BPPV patients need closer follow-up and explicit counselling about relapse risk can reduce repeat ED visits.

Neurology · Cureus · 28 Sept

Trajectories of Glycemia Following Acute Pancreatitis: A Prospective Longitudinal Study

After acute pancreatitis, monitor glucose beyond discharge — a substantial share develop persistent dysglycemia, so early HbA1c and fasting glucose testing can catch new diabetes.

Gastroenterology · Cureus · 28 Sept

Emerging Biomarkers in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Current Evidence, Clinical Utility, and Future Perspectives

Cytokeratin-18 fragments, FGF-21, adipokines, inflammatory cytokines, extracellular vesicles, microRNAs, metabolomic signatures and gut microbiota metabolites all show potential, but none meets all criteria to universally replace biopsy.

Gastroenterology · Cureus · 28 Sept

Brexpiprazole in India and the United States: A Comparative Review of Regulatory Status, Clinical Evidence, Market Access, and Evidence Gaps

Brexpiprazole is FDA-approved for schizophrenia, MDD augmentation and Alzheimer's agitation, but India-specific efficacy and access data remain sparse, so prescribing here rests on extrapolated evidence.

Psychiatry · Cureus · 28 Sept

Artificial Intelligence in Contemporary Dentistry: Applications Across Dental Specialties and Future Challenges

Review maps where AI already assists dental diagnosis and treatment planning, so you can judge which tools are ready for your clinic and which remain experimental.

Medicine · Cureus · 28 Sept

Optimal Enteral Iron Dosing in Preterm and Very-Low-Birth-Weight Infants: A Systematic Review and Meta-Analysis

Dose-response data on enteral iron in preterm VLBW infants help you set supplementation that avoids deficiency without added oxidative stress.

Paediatrics · Cureus · 28 Sept

A metabolic-epigenetic switch governs multicellular cardiac repair following succinate dehydrogenase inhibition.

Malonate, an already-usable SDH inhibitor, drove multicellular repair after MI in animals; if replicated, it points to a metabolic route to cardiac regeneration.

Cardiology · Nature cardiovascular research · 28 Sept

Therapeutic upregulation of gene expression in inherited cardiomyopathies from current approaches to future directions.

For haploinsufficiency-driven cardiomyopathy, raising output from the remaining healthy allele is a plausible route to disease-modifying therapy rather than symptom control.

Cardiology · Nature cardiovascular research · 28 Sept

Prophylactic treatment with broadly neutralizing antibody VRC01 selects for escape mutants after infection in Antibody-Mediated Prevention trials.

VRC01 prophylaxis blocks sensitive HIV strains but selects escape mutants in breakthrough infections, so antibody-only prevention may need combination bnAbs to avoid resistance.

General Medicine · Nature microbiology · 28 Sept

Efficacy and safety of garetosmab, an activin A-blocking antibody, in fibrodysplasia ossificans progressiva (OPTIMA): a randomised, double-blind, placebo-controlled, phase 3 trial.

First phase 3 win for an activin A blocker in FOP; if approved, it offers your ultrarare FOP patients the first therapy aimed at halting new heterotopic bone.

General Medicine · Lancet · 28 Sept

Permissive Blood Pressure Targets in Pediatric Critical Care: The PRESSURE Randomized Clinical Trial.

A permissive MAP target may let you use less vasoactive support in hypotensive critically ill children without worsening outcomes.

Paediatrics · JAMA · 28 Sept

Evidence-Based Guideline on Prioritized Issues for the Management of Empyema Thoracis in Children.

Dominant pathogen is Staphylococcus aureus, then Streptococcus pneumoniae. Empirical cloxacillin plus ceftriaxone is conditionally recommended. IPFT versus no IPFT showed no significant difference for critical outcomes; IPFT preferred over VATS.

Paediatrics · Indian pediatrics · 28 Sept

Impact of Step Stool in the Delivery of CPR by Healthcare Providers: a Simulation-Based Study.

Mean compression depth rose 4.5 mm, adequate depth improved 20%, adequate recoil 13%; shortest height tertile gained 10 mm depth. 83.3% reported greater comfort.

Paediatrics · Indian pediatrics · 28 Sept

Immune Checkpoint Inhibitors and Hypothyroidism: An Emerging Public Health Challenge Identified Through a Systematic Review of ClinicalTrials.gov

Checkpoint-inhibitor hypothyroidism is often permanent, so baseline and serial TSH testing is needed to catch lifelong levothyroxine dependence early in survivors.

Oncology · Cureus · 28 Sept

Systemic Glucose-Lowering Therapies and Periodontal and Peri-Implant Outcomes in Adults With Type 2 Diabetes Mellitus: A Systematic Review

Evidence on whether SGLT2 inhibitors and other glucose-lowering classes improve periodontal and peri-implant outcomes in your T2DM patients remains sparse, so current choices rest on glycaemic control alone.

Endocrinology · Cureus · 27 Sept

Photon-Counting Detector CT for Imaging Around Orthopedic and Spinal Metallic Implants: A Systematic Review

PCD-CT reduces metal artifact around orthopedic and spinal hardware, so you can assess adjacent bone and soft tissue that conventional CT obscures.

Radiology · Cureus · 27 Sept

The Effectiveness of Autologous Platelet-Rich Plasma Topical Application Versus Injection in the Healing of Chronic Venous Ulcers

PRP is a low-cost autologous adjunct to compression; knowing whether topical or injected delivery heals venous ulcers faster guides a practical choice in your wound clinic.

General Surgery · Cureus · 27 Sept

Freehand Needle Hybrid Brachytherapy in Complex Gynecological Cancers

Adequate dosimetric coverage of high-risk clinical target volume achieved in all three cases; two had complete response on follow-up imaging, one showed excellent clinical response

Obstetrics & Gynaecology · Cureus · 27 Sept

Comparative Performance of Oxygenation Indices for Mortality Prediction in Patients With Acute Respiratory Distress Syndrome at a Tertiary Care Intensive Care Unit in Bangladesh

45 of 80 patients (56.3%) died. OSI AUC 0.879 (95% CI 0.786-0.977), OI 0.867 (0.788-0.963), PF ratio 0.731 (0.612-0.881); specificity 91.4% for OSI and OI; accuracy 86.3% and 83.8% versus 70%.

Anaesthesiology · Cureus · 27 Sept

Artificial Intelligence in Delirium Care: Predicting, Detecting, and Preventing Delirium in Older Hospitalized Adults

Retrospective studies show promising discrimination and NLP finds delirium information missing from diagnostic codes, but performance often declines on external validation, calibration is inconsistently reported, and few systems have been tested prospectively.

General Medicine · Cureus · 27 Sept

Incisional Hernia Following Ileostomy Closure: Incidence and Associated Factors in a Single-Center Retrospective Cohort Study

Radiological follow-up after ileostomy closure detects incisional hernias that clinical exam misses, so consider imaging before attributing post-closure abdominal complaints to adhesions.

General Surgery · Cureus · 27 Sept