Archive

Combined Transarterial Embolization and Percutaneous CT-Guided Cryoablation of Renal Cell Carcinoma: A Retrospective Single-Center Study

For biopsy-proven RCC in patients unfit for surgery, combined embolization then CT-guided cryoablation was feasible and safe in this 24-patient series, though oncological durability remains unproven.

Urology · Cureus · 27 Sept

Prognostic Value of Conventional Echocardiographic Parameters of Right Ventricular Dysfunction in a Real-World Cohort of Patients With Acute Pulmonary Embolism

TAPSE, S' and RV FAC showed no correlation with PESI (p = 0.084, 0.235, 0.637) or mortality (p > 0.05). RV FAC <35% linked to PESI class (p = 0.026) but failed correction. Mortality 12.5%.

Cardiology · Cureus · 27 Sept

Assessment of Knowledge, Attitudes, and Perceptions Regarding Artificial Intelligence Among Undergraduate Medical Students

60.0% (135) learned about AI mainly from media; 79.6% (179) saw AI as complementing physicians; 41.8% (94) worried about employment; 75.55% (170) wanted AI training in medical school.

Medicine · Cureus · 27 Sept

Atomoxetine for Orthostatic Hypotension in Traumatic and Non-traumatic Spinal Cord Injury: A Case Series From a Neuro-Rehabilitation Setting

When midodrine and fludrocortisone fail in spinal cord injury, atomoxetine may restore blood pressure enough for patients to tolerate rehabilitation sessions.

Neurology · Cureus · 27 Sept

Limited External Validation and Uncertain Clinical Utility of Prediction Models for Bacteriologically Negative Pulmonary Tuberculosis: A Systematic Review

Models that triage smear-negative TB have not been externally validated, so none can yet be trusted to decide who starts treatment.

General Medicine · Cureus · 27 Sept

Masked Triple-Negative Polycythemia Vera Initially Presenting as Iron Deficiency and Pernicious Anemia

Iron deficiency and B12 deficiency can normalise haemoglobin in PV, so check JAK2 and consider masked erythrocytosis before attributing anaemia solely to nutritional causes.

General Medicine · Cureus · 27 Sept

Large, Life-Threatening Right Ventricular and Pulmonary Artery Thrombus Revealing Antiphospholipid Syndrome: The Role of Risk Stratification and Thrombolytic Therapy

In intermediate-risk PE with a large right ventricular thrombus, risk stratification plus thrombolysis can avert sudden haemodynamic collapse, and antiphospholipid syndrome should be excluded.

Cardiology · Cureus · 27 Sept

Beyond Digoxin Toxicity: A Fatal Case of BRASH Syndrome Triggered by Community-Acquired Pneumonia

In a bradycardic, hyperkalaemic, shocked patient on AV nodal blockers, think BRASH syndrome — the fix is stopping the drug and correcting potassium, not pacing.

Cardiology · Cureus · 27 Sept

Statutory Premarital Haemoglobinopathy Screening, Marriage Decisions, and Affected Births: A Systematic Review

Pooled proportion of at-risk couples not proceeding with marriage was 33.6% (95% CI 16.3-56.6%; I²=99.1%). Three programmes reported 75%-100% reductions in affected births, but comparisons were uncontrolled.

Obstetrics & Gynaecology · Cureus · 26 Sept

Ischemic Colitis in the Setting of Tirzepatide Use: A Potentially Underrecognized Adverse Effect

Consider tirzepatide in the differential when patients on GLP-1/GIP agonists present with acute severe abdominal pain, especially with prior ischemic colitis.

Gastroenterology · Cureus · 26 Sept

Frequency and Spectrum of Ocular Manifestations Among Patients With Systemic Autoimmune Rheumatic Diseases: A Retrospective Cross-Sectional Study

Roughly half of autoimmune rheumatic disease patients had ocular involvement, so screen for dry eye and inflammatory eye disease even when patients do not report visual symptoms.

Ophthalmology · Cureus · 26 Sept

Early Vasopressor Initiation Before Complete Fluid Resuscitation in Adults With Septic Shock: A Systematic Review

Review finds no clear mortality signal for starting noradrenaline before the 30 mL/kg bolus, so timing remains a bedside judgement rather than a protocol.

Anaesthesiology · Cureus · 26 Sept

The Efficacy and Safety of Etrasimod for the Induction and Maintenance of Remission in Moderate to Severe Ulcerative Colitis: An Updated Systematic Review and Meta-Analysis of Randomised Controlled Trials

Clinical remission: RR 2.63 (1.91-3.62) at Week 12 and RR 2.87 (1.89-4.37) beyond 40 weeks. Serious adverse events RR 1.06 (0.61-1.85); no deaths.

Gastroenterology · Cureus · 26 Sept

Validity of a 10-Item Menstrual Quality-of-Life Measure in Women With Heavy Menstrual Bleeding

A validated 10-item tool gives you a quick, structured way to quantify how heavy bleeding affects daily life, rather than relying on subjective report alone.

Obstetrics & Gynaecology · Cureus · 26 Sept

Leukocyte-Poor Platelet-Rich Plasma in Foot and Ankle Tendinopathies in Patients With Spondyloarthritis and Rheumatoid Arthritis: A Dual-Center Observational Study

Plantar fascia thickness fell from 0.75 to 0.37 cm and pain from NRS 9 to 1; in RA, pain fell from 8.36 to 0.48, with resolution of effusion, power Doppler signal and partial tears.

Orthopaedics · Cureus · 26 Sept

Posterior Neck Pain as the Initial Manifestation of Giant Cell Arteritis: A Diagnostic Challenge

Occipital headache or neck pain without temporal tenderness can still be GCA in older patients; consider ESR/CRP and steroids before vision loss occurs.

General Medicine · Cureus · 26 Sept

Evaluation of the Impact of Osteoporosis and Rheumatoid Arthritis on the Outcomes of Nonsurgical Endodontic Therapy: A Prospective Cohort Study

All groups showed significant radiographic healing over six months (p < 0.001). Healthy controls healed significantly more than OP and RA groups at six months (p < 0.05), with higher residual radiolucency and PAI scores in both disease groups.

Orthopaedics · Cureus · 26 Sept

Effects of Sleep Deprivation on Oral Health: A Literature Review

No original data or effect sizes reported. Sleep loss is proposed to drive oral disease via immune dysregulation, salivary changes, glycemic dysregulation, bruxism and obstructive sleep apnea.

General Medicine · Cureus · 26 Sept

The Impact of Ultrasound-Guided Rectus Sheath Blocks on Intraoperative Anesthetic Requirements and Early Recovery in Laparoscopic Surgery: A Retrospective Cohort Study

Ultrasound-guided rectus sheath blocks may cut intraoperative propofol, opioid and dexmedetomidine use and speed early recovery after laparoscopic surgery, though retrospective design limits inference.

Anaesthesiology · Cureus · 26 Sept

Recurrent Pneumococcal Meningitis Without Cerebrospinal Fluid Pleocytosis and With Fulminant Septic Shock: A Case Report

CSF showed no findings strongly suggestive of meningitis; cultures from blood, urine and CSF grew Streptococcus pneumoniae only the day after death, which occurred on the day of admission

Neurology · Cureus · 26 Sept

Unexpected Cardiotocographic Deterioration in Fetal Transient Abnormal Myelopoiesis

At 38+1 weeks, CTG showed markedly reduced baseline variability with recurrent late decelerations, prompting emergency cesarean delivery; the neonate had leukocytosis with circulating blasts and placental intravascular blasts

Obstetrics & Gynaecology · Cureus · 26 Sept

Non-invasive Neurally Adjusted Ventilatory Assist (NIV-Nava): Four-Year Experience in a Level III Neonatal Intensive Care Unit

NIV-NAVA synchronises support to the diaphragm's electrical signal, so consider it for preterm infants failing standard non-invasive ventilation before escalating to intubation.

Paediatrics · Cureus · 26 Sept

Endoscopic and Histological Diagnosis of Gastrointestinal Amyloidosis: A Narrative Review

No primary numerical data are reported; the review concludes that targeted gastrointestinal biopsy during endoscopy is the most reliable approach for early tissue confirmation

Gastroenterology · Cureus · 26 Sept

Central Auditory Processing Disorder in Children: A Multidisciplinary Approach

No quantitative results reported. The panel describes roles for each specialty: otolaryngology excludes peripheral causes, audiology tests central processing, psychology assesses cognitive and emotional factors.

Paediatrics · Cureus · 26 Sept

Mixed Autoimmune Hemolytic Anemia as the Initial Manifestation of Systemic Lupus Erythematosus: A Case Report

Hemoglobin 34 g/L, DAT positive for both IgG and IgM, ANA, anti-dsDNA and anti-Smith positive. Remission achieved with prednisolone, mycophenolate mofetil, belimumab and hydroxychloroquine.

General Medicine · Cureus · 26 Sept

Spatiotemporal Analysis of Dengue Incidence and Associated Factors: An Ecological Study Across Municipalities in Bahia, Brazil (2019-2024)

Incidence was lowest in 2021 (166.6 per 100,000) and highest in 2024 (1,558.7 per 100,000). Income was positively associated with incidence; sewerage coverage and Black/mixed-race proportion were negatively associated in 2024.

General Medicine · Cureus · 26 Sept

Glycemic Dynamics and Management Strategies in Individuals With Type 1 Diabetes During Ramadan: A Continuous Glucose Monitoring-Based Narrative Review

Glycaemic outcomes were heterogeneous, ranging from deterioration to temporary improvement or stability. Hypoglycaemia exposure did not appear to increase; postprandial hyperglycaemia clustered around the evening and pre-dawn meals was the predominant and most variable challenge.

Endocrinology · Cureus · 26 Sept

Relationship Between Gallbladder Wall Thickness and Perioperative Outcomes in Patients Undergoing Laparoscopic Cholecystectomy

Thickened gallbladder wall on preoperative imaging predicts harder dissection and worse perioperative outcomes, so plan ports, timing and conversion risk before elective laparoscopic cholecystectomy.

General Surgery · Cureus · 25 Sept

Access to Essential Medications for Burn Management Among Rural Communities in India: A Community-Based Cross-Sectional Study

Rural patients reaching you with burns may lack even basic topical and analgesic supplies at home, so plan discharge counselling and stock guidance accordingly.

General Surgery · Cureus · 25 Sept

Baseline Predictors of Crestal Bone Maintenance and Implant Stability Following Immediate Implant Placement With Platelet-Rich Fibrin: A Retrospective Observational Study

Baseline local and patient factors, not PRF alone, predicted crestal bone maintenance and stability after immediate implant placement, so case selection matters more than the adjunct.

Orthopaedics · Cureus · 25 Sept

Sequential Organ Failure Assessment Score as a Predictor of Intensive Care Unit Mortality in Patients With Maxillofacial Trauma: A Prospective Observational Study

25 of 130 died. Non-survivors had higher admission SOFA (11.0 ± 3.5 vs. 6.5 ± 3.0). A ΔSOFA above 1.5 gave 92.0% sensitivity and 81.0% specificity for mortality.

Anaesthesiology · Cureus · 25 Sept

Millions of Americans don't have a surgeon in their home county: study

Quantifies how far patients travel for surgical care, a workforce-access problem Indian districts also face when planning referral pathways.

General Surgery · Fierce Healthcare · 25 Sept

Comparison of Vocal Cord Function in Patients Undergoing Thyroid Surgery With and Without Microscopic Assistance

Microscopic assistance during thyroidectomy may reduce recurrent laryngeal nerve injury and preserve vocal cord function, so consider it for high-risk dissections.

General Surgery · Cureus · 25 Sept

Sorafenib-Induced Hand-Foot Skin Reaction in a Patient With Acute Myeloid Leukemia Following Haploidentical Stem Cell Transplantation: A Case Report

Painful symmetrical hyperkeratotic plantar plaques appeared approximately eight weeks after starting sorafenib, impairing daily activities; managed with topical keratolytic and corticosteroid therapy.

Oncology · Cureus · 25 Sept

Circadian-Based Optimization of Pharmacotherapy in Chronic Diseases: Integrating Pharmacokinetics, Pharmacodynamics, and Disease Rhythm

Timing some chronic-disease drugs to the body clock can change efficacy and toxicity, so review whether your patients' dosing schedules match their disease rhythm.

General Medicine · Cureus · 25 Sept

Sudden Onset Occipital Headache as a Presenting Feature of Ischaemic Stroke

MRI showed a 3.5 cm acute right occipital infarct; CT was normal. Formal perimetry revealed a left superior homonymous quadrantanopia missed on bedside confrontation.

Neurology · Cureus · 25 Sept

Stroke Mimics in a Tertiary Comprehensive Stroke Center: Implications for Healthcare Provider Education

True strokes were 35.1% (221/630); mimics 64.9% (409/630). Leading mimics: sepsis 5.7%, migraine 4.6%, seizure 3.3%, subdural hematoma 3.3%, hypertensive emergency 3.3%.

Neurology · Cureus · 25 Sept

Persistent Type B Hyperlactataemia as a Diagnostic Clue to Occult Diffuse Large B-cell Lymphoma-Associated Haemophagocytic Lymphohistiocytosis

Lactate stayed elevated despite fluids and no acidosis; HScore 186 with hypertriglyceridaemia and raised LDH. Bone marrow biopsy confirmed DLBCL. R-mini-CHOP normalised lactate, counts and liver function, with complete metabolic response on PET-CT after two cycles.

General Medicine · Cureus · 25 Sept

Long-Term Cardiovascular, Thromboembolic, and Malignancy Safety of Janus Kinase (JAK) Inhibitors in Dermatologic and Rheumatologic Populations: A Narrative Comparative Review

Before starting long-term JAK inhibitors for psoriasis or rheumatoid arthritis, weigh the persistent cardiovascular, thromboembolic and malignancy signals against the patient's baseline risk.

Medicine · Cureus · 25 Sept

Management, Practice, and Outcomes of Fragility Fractures and Osteoporosis Care at a Tertiary Hospital in Riyadh, Saudi Arabia

Reinforces that post-fragility-fracture osteoporosis treatment is routinely missed, so build secondary-prevention pathways rather than relying on age to flag risk.

Orthopaedics · Cureus · 25 Sept