Archive

Neurotoxicity and Status Epilepticus After Inadvertent Intrathecal Tranexamic Acid: A Case Report

No block developed; severe back and gluteal pain, myoclonus and generalised tonic-clonic convulsions unresponsive to midazolam. Comatose on day three, extubated and oriented by day five, discharged home on day eight. Normal examination at three months.

Anaesthesiology · Cureus · 4d

Current Evidence Regarding the Safety and Effectiveness of Early Weightbearing and Accelerated Rehabilitation Following Patellar Instability Surgery: A Scoping Review

Evidence on early weightbearing after MPFL reconstruction is still too heterogeneous to justify a standard protocol, so your post-op rehab orders remain a judgement call.

Orthopaedics · Cureus · 4d

Efficacy and Safety of Levetiracetam Versus Fosphenytoin in Adult Convulsive Status Epilepticus: An Open-Label Randomized Controlled Trial

Gives you local randomised evidence for choosing between two second-line IV agents when diazepam fails, rather than relying on habit or imported guidelines.

Neurology · Cureus · 4d

The Adolescent Indication for Buprenorphine: What It Is, What It Is Not, and Why It Matters

Adolescents with opioid use disorder are the least likely to get buprenorphine despite fentanyl-era mortality; check whether your age and consent assumptions are blocking initiation.

Psychiatry · Cureus · 4d

Risk factors for surgical site infections following lower-segment caesarean section.

Knowing which of your post-LSCS patients carry the highest SSI risk — and the local antibiogram — lets you target prophylaxis and discharge counselling rather than treat blindly.

Obstetrics & Gynaecology · Indian journal of medical research · 4d

Foodborne outbreak following a mass gathering in Karnataka, India: Epidemiological and environmental evidence implicating an uncooked food item.

Shigella spread via an uncooked item with a 34-hour incubation and 37% attack rate — ask about shared food exposure when diarrhoea clusters after local events.

General Medicine · Indian journal of medical research · 4d

Preoperative screening for cognitive dysfunction including dementia among the elderly.

Undocumented mild cognitive impairment predicts postoperative delirium and mortality; a brief preoperative screen lets you flag these elderly patients for closer monitoring and family counselling.

Anaesthesiology · National medical journal of India · 4d

Head and neck cancer burden attributable to tobacco use in India: National and region-wise estimates.

Quantifies how much head and neck cancer in your catchment is tobacco-attributable, giving state-level numbers to anchor cessation counselling and screening arguments.

Oncology · Indian journal of medical research · 4d

Coronary CT Angiography versus Intravascular Ultrasound Guidance for PCI.

If pre-procedure CCTA matches IVUS guidance for outcomes, you can plan PCI non-invasively and spare patients an extra intracoronary imaging step.

Cardiology · NEJM · 4d

Protein-based resistance in-silico model (PRISM-TB) for rapid prediction of drug-resistant tuberculosis using machine learning.

Random Forest correctly identified 351 of 374 WHO-graded resistant mutations (recall 0.939, accuracy 0.818); Extra Trees had F1-score 0.942, accuracy 0.941. Random Forest reached ROC-AUC 0.973 using only 10 features.

General Medicine · Indian journal of medical research · 4d

Digital reminder systems for improving adherence to anti-rabies vaccination among animal bite victims: A systematic review.

All three reported improved adherence. Vaccination completion was 70% vs 53% with telephonic reminders and 93% vs 78% with SMS. Tanzanian SMS adherence across four doses was 62%, 50%, 29%, 13% versus 48%, 41%, 22%, 7%.

General Medicine · Indian journal of medical research · 4d

Treatment and tracking algorithm for iron deficiency anaemia among children and adolescents- a policy informed evidence- based framework for India.

Two algorithms were produced, one for mild and one for moderate-to-severe anaemia, covering treatment initiation, follow-up and response assessment; haemoglobin is first-line testing, with serum ferritin and CRP reserved for non-responders.

Paediatrics · Indian journal of medical research · 4d

Circulating biomarkers for diagnosis of doxorubicin-induced cardiotoxicity in breast cancer patients: A prospective observational study.

LVEF fell from 65.00±2.17% to 59.50±5.47% and GLS from -19.04±1.87% to -15.37±1.79%. GLS associated with hs-Troponin I (P=0.04), IL-33 (P=0.04) and miR126-3p (P=0.006); LVEF with hs-Troponin I (P=0.03) and IL-33 (P=0.04).

Oncology · Indian journal of medical research · 4d

A Case Report of Wernicke's Encephalopathy During a Pregnancy Complicated by Preeclampsia: A Diagnosis Not to Be Overlooked

In a preeclamptic patient with confusion or ataxia, consider thiamine deficiency from hyperemesis before attributing it to eclampsia — it is treatable and easily missed.

Obstetrics & Gynaecology · Cureus · 4d

Beyond Initial Accuracy: Long-Term Aging and Clinical Stability of 3D-Printed Dental Resins in the Oral Environment

Before you prescribe printed occlusal devices or denture bases for long-term use, note that durability evidence is still largely in vitro and short-term, not clinical.

Medicine · Cureus · 5d

Severe Propofol Infusion Syndrome Managed With Multimodal Critical Care: A Case Report

After four days of propofol for refractory status epilepticus, abrupt bradycardia and shock signal PRIS — stop the infusion early and support haemodynamically rather than escalate sedation.

Anaesthesiology · Cureus · 5d

Diagnostic Accuracy of Transvaginal Ultrasound Versus Magnetic Resonance Imaging for Deep Infiltrating Endometriosis: A Histopathologically Correlated Prospective Study

Head-to-head against histopathology tells you whether to start with TVUS or send straight to MRI when DIE is suspected, sparing women an unnecessary scan.

Obstetrics & Gynaecology · Cureus · 5d

From Pseudomembrane to Molecular Confirmation: A Laboratory-Confirmed Outbreak of Toxigenic Respiratory Diphtheria in Nagpur, India

Toxigenic diphtheria still clusters in under-vaccinated Indian communities — keep it on your differential for a grey pseudomembrane and check immunization status.

General Medicine · Cureus · 5d

Establishing Biological Reference Intervals From 2 Million Routine Hospital Laboratory Results of 59,141 Patients Using an Indirect Method: Evidence From Adult and Pediatric Moroccan Populations

Reference intervals were established for 26 analytes across age and sex groups, with 90% bootstrap confidence intervals. Transaminases, alkaline phosphatase, urea and creatinine agreed with existing intervals; sodium, calcium, albumin, glucose, HbA1c, uric acid, GGT and LDH limits shifted.

General Medicine · Cureus · 5d

Analysis of Factors Associated With Hemorrhage Post-radiotherapy for Brain Metastasis: A Population-Based Study

Quantifies which metastasis and treatment factors predict post-RT intracranial hemorrhage, helping you decide surveillance imaging intensity and counsel patients on bleeding risk.

Oncology · Cureus · 5d

Persistent Borrelia burgdorferi Peptidoglycan in Postinfectious Lyme Arthritis: Innate Immune Sensing and Translational Implications

No study has shown that persistent peptidoglycan or NOD2 signalling causes human postinfectious synovitis; human evidence is limited to peptidoglycan detection in synovial fluid from closely related research groups, not independently replicated.

General Medicine · Cureus · 5d

Dexmedetomidine Versus Propofol for Early Postoperative Sedation After Adult Cardiac Surgery: A Narrative Review of Hemodynamic Safety and Recovery Outcomes

Weighs dexmedetomidine's bradycardia and hypotension against propofol's smoother wake-up when choosing sedation for your post-cardiac-surgery patients awaiting extubation.

Anaesthesiology · Cureus · 5d

Comparison of Lyophilized and Dry Powder Colistin Formulations for Nebulized Treatment of Pneumonia Caused by Carbapenem-Resistant Gram-Negative Bacteria: A Retrospective Before-and-After Cohort Study

Day-14 favorable clinical response was 65.0% with lyophilized versus 63.3% with dry powder colistin (p=0.904). Day-7 response (90.0% vs 76.7%) and eradication (90.0% vs 66.7%) favoured lyophilized but were not statistically significant.

General Medicine · Cureus · 5d

Severe Perioperative Anaphylaxis With Positive Skin Tests to Midazolam and Rocuronium During Breast Cancer Surgery: A Case Report

Midazolam is rarely blamed in induction anaphylaxis; when several drugs go in at once, skin testing all of them—including the sedative—identifies the culprit and prevents re-exposure.

Anaesthesiology · Cureus · 5d

Exploring Infrared Lamp Therapy for Episiotomy Recovery: A Systematic Review of Postnatal Wound Healing Outcomes

A low-cost, non-drug option for perineal pain and slow episiotomy healing would suit Indian postnatal wards, but this review's strength depends on the few small trials behind it.

Obstetrics & Gynaecology · Cureus · 5d

One-Year Infection Eradication and Clinical Outcomes After Completed Two-Stage Revision for Hip and Knee Periprosthetic Joint Infection: A Retrospective Cohort Study

Confirms what to quote to patients weighing two-stage revision for PJI: roughly one-year eradication and functional outcomes from a real-world cohort, not trial conditions.

Orthopaedics · Cureus · 5d

Outcomes and Benefits of Using Twice Daily Nebulised Hypertonic Saline in T2-Low and T2-High Asthma With Bronchial Hypersecretion: A Retrospective Cohort Study

Mean exacerbations fell from 2.18 to 1.20 per year (p < 0.001) and mean hospital admissions from 0.43 to 0.15 (p=0.006); 44 of 48 tolerated treatment beyond one year

General Medicine · Cureus · 5d

Codeine-Associated Secondary Adrenal Insufficiency: A Case Report

Before labelling unexplained fatigue and low cortisol as primary adrenal failure, ask about chronic codeine use — it can suppress ACTH and mimic hypopituitarism.

Endocrinology · Cureus · 5d

Assessment of Knowledge About AI and Its Uses Among Dental Students and Faculty at Taibah University: A Cross-Sectional Study

67.2% understood AI's basic principles and 82.4% were familiar with its uses; 5.1% had no knowledge and 12% were uncertain about AI's role in dentistry. No significant difference between students and faculty.

Medicine · Cureus · 5d

Menopausal Status, Age at Menopause, and Fracture Risk in Women: A Systematic Review of Observational Studies

Earlier natural menopause was associated with higher fracture risk in several analyses, but results were inconsistent and varied by exposure definition, comparison group, population and fracture outcome. Only four reports specified fragility fracture.

Obstetrics & Gynaecology · Cureus · 5d

Outcomes Following Breast-Conserving Surgery for Positive Radial Margins: A Five-Year Longitudinal Study

Quantifies residual disease and five-year outcomes after re-excision for positive radial margins, informing how aggressively you counsel patients before a second surgery.

Oncology · Cureus · 5d

A Comparative Study on the Diagnostic Utility of Ultrasonography and Conventional Radiography With Computed Tomography as the Gold Standard in the Detection of Facial Trauma Fractures

Ultrasound can rule in facial fractures without radiation when CT is unavailable, but know its limits before replacing radiography in your trauma workup.

Radiology · Cureus · 5d

Clinical Features, Treatment, and Outcomes of Sepsis by Culture Status in Hospitalized Adults: A Retrospective Cohort Study

Culture-negative sepsis is common in Indian hospitals; this cohort shows whether your culture-negative patients differ in treatment and mortality from culture-positive ones.

General Medicine · Cureus · 5d

Short- and Long-Term Efficacy and Safety Evaluation of Multiwavelength Photobiomodulation in Nonexudative Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis

Dry AMD has no approved therapy; this pooled analysis of a non-invasive light treatment tells you whether the visual gains hold beyond the short term.

Ophthalmology · Cureus · 5d

Efficacy and Safety of Janus Kinase Inhibitors in Polymyalgia Rheumatica: A Systematic Review

If JAK inhibitors hold up, your steroid-dependent PMR patients may get a taper option that avoids years of cumulative glucocorticoid toxicity.

General Medicine · Cureus · 5d

Surgical De-escalation After Neoadjuvant Immunotherapy for Cutaneous Squamous Cell Carcinoma: Oncological Safety and Reconstructive Consequences

Before shrinking surgery after neoadjuvant PD-1 blockade in resectable cSCC, know that the evidence for omitting or reducing local treatment is still unresolved.

Oncology · Cureus · 5d

Probable Rapid Eye Movement Sleep Behavior Disorder Associated With Escitalopram in a Patient With Schizoaffective Disorder: A Case Report

Before adding a sedative for nocturnal agitation, ask about dream enactment in patients on escitalopram — dose reduction may resolve it and avoid a mislabelled primary-illness flare.

Psychiatry · Cureus · 5d

Hydrocortisone Versus Dexamethasone Initiated in the Second Postnatal Week in Preterm Neonates at Risk of Bronchopulmonary Dysplasia: A Retrospective Exploratory Comparative Study

When starting steroids in week two for BPD risk, this comparison helps you weigh hydrocortisone against dexamethasone, though its retrospective design limits how far you can generalise.

Paediatrics · Cureus · 5d

Clinical Characteristics and Outcomes of Patients Undergoing Emergency Surgery for Intestinal Obstruction at a Tertiary Care Centre in Eastern India

Local outcome data on emergency obstruction surgery helps you counsel patients and families on realistic morbidity and mortality before consent.

General Surgery · Cureus · 5d

Feasibility and Short-Term Outcomes of Desensitization in Sensitized Kidney Transplant Candidates: A Prospective Single-Center Observational Study From India

Shows desensitization is deliverable in an Indian centre, so highly sensitized patients on your waitlist may have a realistic transplant pathway rather than indefinite dialysis.

General Surgery · Cureus · 5d