Archive

Karnataka govt pauses circular on medicine price disclosure by hospitals

Itemised procurement-vs-MRP billing is on hold, so private hospitals in Karnataka face no immediate mandate to reveal medicine margins to patients.

General Medicine · ETHealthworld · 5d

Severe Encephalopathy Associated With Ivermectin Use and Extensive CYP3A4 Inhibition in a Patient Undergoing Self-Directed Treatment for Malignancy

Ask about unregulated self-medication in cancer patients on CYP3A4 inhibitors — this interaction produced severe encephalopathy at doses otherwise tolerated.

General Medicine · Cureus · 5d

Efficacy of High-Velocity Nasal Insufflation in the Treatment of Hypercapnic Respiratory Failure: A Systematic Review and Meta-Analysis

A nasal cannula option may spare hypercapnic patients the mask intolerance and pressure-related harms of NPPV, though randomized evidence remains thin.

General Medicine · Cureus · 5d

Prone positioning and high-frequency oscillatory ventilation in early paediatric acute respiratory distress syndrome (PROSpect): an international, two-by-two factorial, response-adaptive, phase 3, randomised controlled trial.

Phase 3 factorial data on prone positioning and HFOV in early PARDS should settle a common ICU practice question where current evidence is inconclusive.

Paediatrics · Lancet · 5d

Charting a course to men's health and wellbeing: applying a lens of power and politics to improve men's health outcomes.

Men present late and die earlier; recognising gendered and structural barriers in your male patients can prompt earlier screening and referral.

General Medicine · Lancet · 5d

A global men's health epidemiology within an intersectional framework.

Men in marginalised groups carry the heaviest disability burden — screening and risk-factor work in these patients is where the gap is widest.

General Medicine · Lancet · 5d

Non-invasive tests in metabolic dysfunction-associated steatotic liver disease: the LITMUS prospective multicentre diagnostic accuracy study.

For at-risk MASH, SomaSignal reached AUC 0.83 (95% CI 0.80-0.85) and no other test met the AUC above 0.80 threshold. For advanced fibrosis SomaSignal reached 0.92 (0.90-0.94); for cirrhosis FibroMeter-VCTE reached 0.94 (0.90-0.97).

Gastroenterology · Lancet · 5d

Linezolid-Induced Cardiac Arrest in an Adolescent: A Case Report

Linezolid is used widely for resistant gram-positive infections in ventilated children; this report flags a rare arrhythmic risk worth monitoring for on prolonged courses.

Paediatrics · Cureus · 5d

Timing of Surgical Intervention for Traumatic Spinal Injury and Its Association With 30-Day Functional Outcomes: A Single-Center Retrospective Study

Adds single-centre evidence on whether early fixation after traumatic spinal injury improves 30-day function, though retrospective design limits how firmly you can apply it.

Orthopaedics · Cureus · 6d

FDA Approves First Plasmid DNA-based Immunotherapy for Adults with Recurrent Respiratory Papillomatosis

Adults with recurrent respiratory papillomatosis who face repeated debulking surgeries now have a first-in-class DNA immunotherapy option targeting HPV-driven disease.

General Medicine · FDA — Press Announcements · 6d

Associations of Age, Sex, and Diabetes Duration With Sensorineural Hearing Loss Severity in Patients With Type 2 Diabetes Mellitus: A Retrospective Study

Longer diabetes duration and older age track with worse hearing loss, so consider audiometry in long-standing T2DM patients who report hearing difficulty.

Endocrinology · Cureus · 6d

Consolidative Prostate Radiotherapy in de Novo Oligometastatic Mixed Small Cell Neuroendocrine Prostate Cancer: A Case Report

Rare mixed small-cell neuroendocrine prostate cancer can respond to consolidative radiotherapy to the primary even with oligometastases; consider tissue diagnosis when PSA is low relative to burden.

Oncology · Cureus · 6d

Intraperitoneal Small Round Cell Tumor Suggestive of Extraskeletal Ewing Sarcoma in an Eight-Year-Old Girl: Conversion to Resection and Adjuvant Volumetric Modulated Arc Therapy

Shows that a vessel-encasing paediatric EES can be converted to resectable disease and consolidated with VMAT, a pathway worth considering before calling such masses inoperable.

Oncology · Cureus · 6d

Pretreatment Factors Associated With Response to Eruption Guidance Appliance Therapy in Class II Division 1 Malocclusion: A Preliminary Pilot Study

Before prescribing an eruption guidance appliance for Class II div 1, note this pilot's cephalometric predictors of who responds — but 12 patients is hypothesis-generating only.

Orthopaedics · Cureus · 6d

Fetal and Neonatal Outcomes in Pregnancies Complicated by Antenatal Vaginal Bleeding: A Retrospective Study at a Tertiary Care Center

Antepartum bleeding signals placental pathology and preterm risk; this cohort links causes of bleeding to concrete neonatal outcomes, sharpening your counselling and delivery planning.

Obstetrics & Gynaecology · Cureus · 6d

Medial Discoid Meniscus in a Pediatric Patient: A Case Report

A medial discoid meniscus is rare and easily missed on imaging; consider it in a child with medial knee pain or locking before assuming a simple tear.

Orthopaedics · Cureus · 6d

The “Well-Appearing Trap”: Cardiac Point-of-Care Ultrasound (POCUS) Prompting the Diagnosis of Anomalous Left Coronary Artery From the Pulmonary Artery (ALCAPA)

In a well-looking infant with poor feeding or sweating, bedside POCUS showing reduced LV function and a dilated RCA should prompt urgent echo for ALCAPA before discharge.

Paediatrics · Cureus · 6d

Who’s responsible when clinical AI goes wrong? AMA weighs in

If you use AI tools in practice, this framework sketches who owns a wrong output — you, the vendor, or the health system — before liability lands on you.

General Medicine · Fierce Healthcare · 6d

Subinguinal Orchidectomy for Testicular Tumour: A Regional Analysis of Oncological Control and Postoperative Outcomes

All surgical margins negative. Three patients (5.8%) recurred, all nodal, at mean 20.3 ± 13.8 months; no local or scrotal recurrence. Complications in 10 (19.2%), Clavien-Dindo IIIb in five (9.6%).

Urology · Cureus · 6d

Early Visual and Choroidal Responses to Oral Eplerenone in Acute Central Serous Chorioretinopathy: A Retrospective Comparative Cohort Study

Adds retrospective support for oral eplerenone to speed subretinal fluid resolution in acute CSCR, but the design cannot settle whether it beats observation alone.

Ophthalmology · Cureus · 6d

ABNORMAL Score for the Etiologic Triage of Parkinsonism: Development and Apparent Diagnostic Performance

A bedside score bundling onset age, tempo and dopaminergic response could help you separate PD from atypical parkinsonism earlier, though it still needs external validation.

Neurology · Cureus · 6d

From Remission to Complication: Hemophagocytic Lymphohistiocytosis and Avascular Necrosis During Brentuximab Therapy in Hodgkin Lymphoma

On brentuximab for relapsed Hodgkin's, watch for HLH and avascular necrosis — rare but treatable complications that can mimic progression or infection.

Oncology · Cureus · 6d

Wrong Turn at the Renal Vein: Malposition of a Right Femoral Tunneled Hemodialysis Catheter Into the Left Renal Vein

A 44-cm right femoral cuffed catheter ascended the IVC and turned into the left renal vein on abdominal radiography; it was exchanged over a guidewire for a 42-cm catheter terminating in the intrahepatic IVC, which dialysed normally

Urology · Cureus · 6d

Evaluating an Outpatient Rapid Preoperative Optimization Protocol for Poorly Controlled Graves’ Disease: A Retrospective Cohort Study

A structured outpatient protocol may shorten the 4-8 week thionamide wait before thyroidectomy, reducing thyroid storm risk in poorly controlled Graves' patients.

Endocrinology · Cureus · 6d

Juvenile Dentatorubral-Pallidoluysian Atrophy (DRPLA) in a Patient From Northeastern Mexico: Whole-Genome Sequencing With ExpansionHunter as a Key Diagnostic Tool

WGS with ExpansionHunter flagged a pathogenic-range ATN1 repeat; orthogonal testing confirmed alleles of 13 and 64 CAG repeats, supporting the molecular diagnosis of DRPLA.

Neurology · Cureus · 6d

Weekly Rundown: Doximity launches DoseCheck; AI recommends costlier care than doctors, study finds

A study finding AI models recommend costlier care than doctors is a caution before you let triage or ordering tools shape decisions for your patients.

General Medicine · Fierce Healthcare · 6d

Bilateral Acute Limb Ischaemia Following Myocardial Infarction in a Patient With Left Ventricular Thrombus and Severe Peripheral Arterial Disease

After an MI, new limb pain and pulseless cold legs mean embolisation until proven otherwise — this case shows LV thrombus can throw clot to both limbs within a week.

Cardiology · Cureus · 6d

Erythromelalgia Unmasking a Triple-Negative Essential Thrombocytosis Phenotype After Recurrent Arterial Thrombosis Misdiagnosed As Peripheral Vascular Disease

Burning extremity pain with thrombocytosis should prompt JAK2/calreticulin workup before labelling it peripheral vascular disease; triple-negative essential thrombocytosis still carries real thrombotic risk.

General Medicine · Cureus · 6d

Operationalising a Comprehensive Lactation Management Centre in a Tertiary NICU in North India: A Retrospective Implementation Study With Before-After Comparison of Breastfeeding and Counselling Coverage

Embedding counselling and donor milk banking in the NICU improved breastfeeding and counselling coverage — a replicable model for your unit's feeding protocols.

Paediatrics · Cureus · 6d

Industry Voices—The other AI divide is already opening in healthcare

If your hospital lacks AI infrastructure, your patients may soon get slower diagnostics and less coordinated care than those at better-resourced centres.

Medicine · Fierce Healthcare · 6d

Early Phosphate-to-Amino Acid Provision and Refeeding Syndrome in Extremely Low Birth Weight Infants: A Systematic Review

If you start high amino acids in ELBW infants, watch phosphate: hypophosphatemia with hypercalcemia signals a neonatal refeeding syndrome that early phosphate provision may prevent.

Paediatrics · Cureus · 6d

Beyond the Obvious Provoking Factor: May-Thurner Syndrome Presenting With Extensive Venous Thromboembolism in an 18-Year-Old Male

In a young man with extensive unprovoked left-sided DVT, consider iliac vein compression and image the pelvis rather than stopping at standard thrombophilia workup.

General Medicine · Cureus · 6d

Dexamethasone in Orthognathic Surgery: A Narrative Review of Pharmacological Rationale, Clinical Efficacy, Dosing Strategies, and Safety

Corticosteroids consistently reduce early facial oedema, clearest in the first 24 to 48 hours. Doses from 5 mg to 40 mg tested; higher doses gave no greater benefit. The one orthognathic trial with a separate postoperative arm found no added benefit.

Anaesthesiology · Cureus · 6d

Antimicrobial Susceptibility Pattern of Multidrug-Resistant Acinetobacter Species Isolated From Intensive Care Units in a Tertiary Care Hospital

Local ICU antibiograms for MDR Acinetobacter should steer empiric choice in your unit; check whether your hospital's resistance pattern matches before defaulting to carbapenems.

General Medicine · Cureus · 6d

STAT+: FDA, CMS scramble to avoid regulatory logjam as more states look to test AI in clinical settings

If you pilot or buy AI tools, expect shifting state-versus-federal rules on approval and reimbursement; clarify which regulator governs your deployment before signing.

Medicine · STAT News — Health Tech · 6d

Epidermal Growth Factor Receptor (EGFR) Mutations in Rare Histological Subtypes of Ovarian Cancer

If rare ovarian subtypes carry actionable EGFR mutations, testing beyond high-grade serous histology could open targeted options for patients currently managed on generic chemotherapy.

Oncology · Cureus · 6d

Adjunctive Taurolidine-Citrate-Urokinase Lock Treatment for Peritoneal Dialysis-Associated Peritonitis: A Case Series of 13 Episodes

A small case series suggesting taurolidine-citrate-urokinase locks may help retain the PD catheter through peritonitis — hypothesis-generating only, no comparator.

Urology · Cureus · 6d

Twelve-Month Albuminuria Response to Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes Mellitus: A Real-World Study

Real-world Indian data showing finerenone lowers albuminuria over 12 months supports adding it to RAS blockade in your diabetic CKD patients, including those with heavy baseline proteinuria.

Endocrinology · Cureus · 6d

Artificial Intelligence-Based Segmentation of Local Anesthetic Spread During Ultrasound-Guided Rectus Sheath Block: An Exploratory Observational Study

If validated, automated spread measurement could standardise how you judge block adequacy instead of eyeballing hypoechoic expansion during rectus sheath blocks.

Anaesthesiology · Cureus · 6d

Doctor's vacations at government medical colleges under Centre’s scanner

If you teach at a government medical college, leave and vacation rules for CHS faculty may change, affecting how you plan academic time and clinical cover.

General Medicine · ETHealthworld · 6d